Effect of ω-3 Polyunsaturated Fatty Acid on Inflammatory Response and Nutritional State of Patients with Gastrointestinal Malignancies after Operation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Liu ¹ , ZHUANG Wen ¹ , CHEN Zhong ²

1.Surgery Center of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China;;
2.Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

ω-3 polyunsaturated fatty acid; Gastric cancer; Colorectal cancer; Inflammatory response; Nutrition

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Objective To research the effect of ω-3 polyunsaturated fatty acid (PUFA) on inflammatory response and nutritional condition after operation for patients with gastrointestinal malignancies. Methods Forty patients with gastrointestinal malignancies were included in this study from February 1st, 2009 to June 1st, 2009. Forty cases were randomly allocated to experimental group (20 cases) and control group (20 cases). Parenteral nutrition was conducted in continuous 7 days after operation. Comparing with control group, a dose of 10 g of ω-3 PUFA was given to experimental group every day in 7 days after operation in addition. Blood samples were gained before operation, the 2nd and 8th day after operation respectively to measure relative indexes about inflammatory response (WBC, neutrophilic granulocyte and C-reaction protein) and nutrition (total protein, albumin, prealbumin, siderophilin and lymphocyte). Reduction of body mass was also recorded. Results The baseline between experimental group and control group was comparable (P gt;0.05). The levels of indexes about inflammatory response (WBC, neutrophilic granulocytem and C-reaction protein) and nutrition (total protein, albumin, prealbumin, siderophilin and lymphocyte) between experimental and control group did not reach statistically significant difference in the 2nd day after operation (P gt;0.05). The levels of neutrophilic granulocyte and C-reaction protein in experimental group were lower than those of control group, and the level of lymphocyte in experimental group was higher than that of control group in the 8th day after operation, and all of them reached statistical significance (P lt;0.05). There was no statistical different in reduction of body mass between experimentalgroupandcontrolgroup.Conclusion ω-3 PUFA can depress the excessively inflammatory reaction and improve the nutritional condition of patients with gastrointestinal malignancies after operation.

Citation： LIU Liu,ZHUANG Wen,CHEN Zhong. Effect of ω-3 Polyunsaturated Fatty Acid on Inflammatory Response and Nutritional State of Patients with Gastrointestinal Malignancies after Operation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(12): 964-967. doi: Copy

1.	Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002 [Ｊ]. CA Cancer J Clin, 2005; 55(2): 74-108.
2.	Boyle P, Leon ME. Epidemiology of colorectal cancer [Ｊ]. Br Med Bull, 2002; 64: 1-25.
3.	Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma [Ｊ]. Ann Surg, 2004; 239(4): 553-560.
4.	任成山，陆海华, 杜晓锋，等. 重度创伤后全身炎症反应综合征和多器官功能障碍综合征 [Ｊ]. 中国危重病急救医学, 2001； 13(11): 690-693.
5.	Richards GA. Lipid nutrients in critical illness [Ｊ]. Clin Pulm Med， 2009； 16(5): 265-269.
6.	Pacht ER. Enteral therapy to decrease morbidity and improve survival in acute respiratory distress syndrome: its time has come [Ｊ]. Crit Care Med, 2006; 34(9): 2492-2493.
7.	黄莚庭. 大肠癌诊治现状与展望 [Ｊ]. 中国普外基础与临床杂志, 2000； 7(1): 44-45.
8.	陈威佐, 陈文元, 罗好曾. 武威市2001~2005 年胃癌发病率分析 [Ｊ]. 中国肿瘤, 2007； 16(5): 309-310.
9.	贾云鹤, 江志伟, 佴永军, 等. 胃癌术后感染和排空障碍与术前营养不良及营养指标的相关研究 [Ｊ]. 肠外与肠内营养, 2005； 12(3)： 143-145.
10.	Evangelista V, Dell’Elba G, Celardo A, et al. TxA2-mediated myocardial ischemia as a consequence of an acute lung inflammatory reaction in the rabbit [Ｊ]. J Thromb Haemost, 2003; 1(2): 314-319.
11.	Wu GH, Zhang YW, Wu ZH. Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients [Ｊ]. World J Gastroenterol, 2001; 7(3): 357-362.
12.	Lin MT, Yeh SL, Yeh CL, et al. Parenteral ω-3 fatty acids modulate inflammatory and immune response in rats undergoing total gastrectomy [Ｊ]. Shock, 2006; 25(1): 56-60.
13.	Calder PC. ω-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic [Ｊ]. Lipids, 2003; 38(4): 343-352.
14.	Calder PC. ω-3 polyunsaturated fatty acids and cytokine production in health and disease [Ｊ]. Ann Nutr Metab, 1997; 41(4): 203-234.
15.	Li Q, Wang M, Tan L, et al. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts [Ｊ]. J Lipid Res, 2005; 46(9): 1904-1913.
16.	Huber TB, Simons M, Hartleben B, et al. Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains [Ｊ]. Hum Mol Genet, 2003; 12(24): 3397-3405.
17.	Zhao Y, Joshi-Barve S, Barve S, et al. Eicosapentaenoic acid prevents LPS-induced TNF-α expression by preventing NF-κB activation [Ｊ]. J Am Coll Nutr, 2004; 23(1): 71-78.
18.	Li H, Ruan XZ, Powis SH, et al. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism [Ｊ]. Kidney Int, 2005; 67(3): 867-874.
19.	王新颖, 李维勤, 李宁, 等. ω-3多不饱和脂肪酸对重症急性胰腺炎病人早期炎性反应的影响 [Ｊ]. 肠外与肠内营养, 2008； 15(4): 214-217.
20.	Tsekos E, Reuter C, Stehle P, et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery [Ｊ]. Clin Nutr, 2004; 23(3): 325-330.
21.	Heys SD, Walker LG, Smith I, et al. Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials [Ｊ]. Ann Surg, 1999; 229(4): 467-477.
22.	刘流，庄文，陈忠. ω-3不饱和脂肪酸促进胃肠道恶性肿瘤患者术后康复的疗效研究 [Ｊ]. 中国普外基础与临床杂志，2009； 16(11): 895-899.

1. Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002 [Ｊ]. CA Cancer J Clin, 2005; 55(2): 74-108.
2. Boyle P, Leon ME. Epidemiology of colorectal cancer [Ｊ]. Br Med Bull, 2002; 64: 1-25.
3. Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma [Ｊ]. Ann Surg, 2004; 239(4): 553-560.
4. 任成山，陆海华, 杜晓锋，等. 重度创伤后全身炎症反应综合征和多器官功能障碍综合征 [Ｊ]. 中国危重病急救医学, 2001； 13(11): 690-693.
5. Richards GA. Lipid nutrients in critical illness [Ｊ]. Clin Pulm Med， 2009； 16(5): 265-269.
6. Pacht ER. Enteral therapy to decrease morbidity and improve survival in acute respiratory distress syndrome: its time has come [Ｊ]. Crit Care Med, 2006; 34(9): 2492-2493.
7. 黄莚庭. 大肠癌诊治现状与展望 [Ｊ]. 中国普外基础与临床杂志, 2000； 7(1): 44-45.
8. 陈威佐, 陈文元, 罗好曾. 武威市2001~2005 年胃癌发病率分析 [Ｊ]. 中国肿瘤, 2007； 16(5): 309-310.
9. 贾云鹤, 江志伟, 佴永军, 等. 胃癌术后感染和排空障碍与术前营养不良及营养指标的相关研究 [Ｊ]. 肠外与肠内营养, 2005； 12(3)： 143-145.
10. Evangelista V, Dell’Elba G, Celardo A, et al. TxA2-mediated myocardial ischemia as a consequence of an acute lung inflammatory reaction in the rabbit [Ｊ]. J Thromb Haemost, 2003; 1(2): 314-319.
11. Wu GH, Zhang YW, Wu ZH. Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients [Ｊ]. World J Gastroenterol, 2001; 7(3): 357-362.
12. Lin MT, Yeh SL, Yeh CL, et al. Parenteral ω-3 fatty acids modulate inflammatory and immune response in rats undergoing total gastrectomy [Ｊ]. Shock, 2006; 25(1): 56-60.
13. Calder PC. ω-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic [Ｊ]. Lipids, 2003; 38(4): 343-352.
14. Calder PC. ω-3 polyunsaturated fatty acids and cytokine production in health and disease [Ｊ]. Ann Nutr Metab, 1997; 41(4): 203-234.
15. Li Q, Wang M, Tan L, et al. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts [Ｊ]. J Lipid Res, 2005; 46(9): 1904-1913.
16. Huber TB, Simons M, Hartleben B, et al. Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains [Ｊ]. Hum Mol Genet, 2003; 12(24): 3397-3405.
17. Zhao Y, Joshi-Barve S, Barve S, et al. Eicosapentaenoic acid prevents LPS-induced TNF-α expression by preventing NF-κB activation [Ｊ]. J Am Coll Nutr, 2004; 23(1): 71-78.
18. Li H, Ruan XZ, Powis SH, et al. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism [Ｊ]. Kidney Int, 2005; 67(3): 867-874.
19. 王新颖, 李维勤, 李宁, 等. ω-3多不饱和脂肪酸对重症急性胰腺炎病人早期炎性反应的影响 [Ｊ]. 肠外与肠内营养, 2008； 15(4): 214-217.
20. Tsekos E, Reuter C, Stehle P, et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery [Ｊ]. Clin Nutr, 2004; 23(3): 325-330.
21. Heys SD, Walker LG, Smith I, et al. Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials [Ｊ]. Ann Surg, 1999; 229(4): 467-477.
22. 刘流，庄文，陈忠. ω-3不饱和脂肪酸促进胃肠道恶性肿瘤患者术后康复的疗效研究 [Ｊ]. 中国普外基础与临床杂志，2009； 16(11): 895-899.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of ω-3 Polyunsaturated Fatty Acid on Inflammatory Response and Nutritional State of Patients with Gastrointestinal Malignancies after Operation

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