Differentiation of Chronic Mass-Forming Type Pancreatitis from Pancreatic Carcinoma by Functional Magnetic Resonance Imaging_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHEN Jinxiu , SONG Bin , WU Bi

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Pancreatic carcinoma; Chronic pancreatitis; Diffusion-weighted magnetic resonance imaging; Magnetic resonance spectrum imaging

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Objective 　To summarize the principle and application of functional MR imaging of pancreatic carcinoma and chronic mass-forming type pancreatitis.
Methods 　Articles about diffusion-weighted imaging (DWI), magnetic resonance spectrum imaging (MRSI) and dynamic contrast-enhanced MR imaging of pancreatic carcinoma and chronic pancreatitis were reviewed and analyzed.
Results 　Functional MR imaging could reflected the differences in molecules diffusion, metabolism and tissue perfusion between pancreatic carcinoma and chronic pancreatitis.
Conclusion 　 As a non-invasive protocol, functional MR imaging can provide useful information in differential diagnosis between chronic mass-forming type pancreatitis and pancreatic carcinoma.

Citation： CHEN Jinxiu,SONG Bin,WU Bi. Differentiation of Chronic Mass-Forming Type Pancreatitis from Pancreatic Carcinoma by Functional Magnetic Resonance Imaging. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(6): 722-725. doi: Copy

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2.	葛春林，郭克建. 胰腺癌可切除性的判断 [J]. 中国普外基础与临床杂志， 2003； 10（6）∶526.
3.	Niederau C, Grendell JH. Diagnosis of pancreatic carcinoma. Imaging techniques and tumor markers [J]. Pancreas, 1992; 7(1)∶66.
4.	Gudjonsson B, Livstone EM, Spiro HM. Cancer of the pancreas: diagnostic accuracy and survival statistics [J]. Cancer, 1978; 42(5)∶2494.
5.	宋彬, 闵鹏秋, 吴苾, 等. 磁共振VIBE序列鉴别胰腺癌与肿块型慢性胰腺炎的价值探讨 [J]. 放射学实践, 2006; 21(51)∶498.
6.	Henriksen O. MR spectroscopy in clinical research [J]. Acta Radiol, 1994; 35(2)∶96.
7.	Cho SG, Lee DH, Lee KY, et al. Differentiation of chronic focal pancreatitis from pancreatic carcinoma by in vivo proton magnetic resonance spectroscopy [J]. J Comput Assist Tomogr, 2005; 29(2)∶163.
8.	Kim T, Murakami T, Takamura M, et al. Pancreatic mass due to chronic pancreatitis: correlation of CT and MR imaging features with pathologic findings [J]. AJR Am J Roentgenol, 2001; 177(2)∶367.
9.	Cho SG, Kim YS, Kim HJ, et al. Chronic hepatitis: in vivo proton MR spectroscopic evaluation of the liver and correlation with histopathologic findings [J]. Radiology, 2001; 221(3)∶740.
10.	Kaplan O, Kushnir T, Askenazy N, et al. Role of nuclear magnetic resonance spectroscopy (MRS) in cancer diagnosis and treatment: 31P, 23Na, and 1H MRS studies of three models of pancreatic cancer [J]. Cancer Res, 1997; 57(8)∶1452.
11.	Wright CE, Tallan HH, Lin YY, et al. Taurine: biological update [J]. Annu Rev Biochem, 1986; 55∶427.
12.	Moreno A, Rey M, Montane JM, et al. 1H NMR spectroscopy of colon tumors and normal mucosal biopsies; elevated taurine levels and reduced polyethyleneglycol absorption in tumors may have diagnostic significance [J]. NMR Biomed, 1993; 6(2)∶111.
13.	Remy C, Arus C, Ziegler A, et al. In vivo, ex vivo, and in vitro one- and two-dimensional nuclear magnetic resonance spectroscopy of an intracerebral glioma in rat brain: assignment of resonances [J]. J Neurochem, 1994; 62(1)∶166.
14.	Chemin-Thomas C, Palévody C, Esclassan J, et al. Combined magnetic resonance imaging and spectrometry for characterization of human pancreatic adenocarcinoma (Capan-1) heterotransplanted in nude mice [J]. Gastroenterol Clin Biol, 1994; 18(10)∶859.
15.	Khan SA, Cox IJ, Thillainayagam AV, et al. Proton and phosphorus-31 nuclear magnetic resonance spectroscopy of human bile in hepatopancreaticobiliary cancer [J]. Eur J Gastroenterol Hepatol, 2005; 17(7)∶733.
16.	Pierpaoli C, Righini A, Linfante I, et al. Histopathologic correlates of abnormal water diffusion in cerebral ischemia: diffusion-weighted MR imaging and light and electron microscopic study [J]. Radiology, 1993; 189(2)∶439.
17.	邢悦，刘荣波. 肝脏磁共振弥散加权成像的研究进展 [J]. 中国普外基础与临床杂志， 2007； 14（3）∶359.
18.	杨洋，宋彬，吴苾. 慢性病毒性肝炎组织病理学分级和磁共振弥散成像的对照研究 [J]. 中国普外基础与临床杂志， 2006； 13（4）∶469.
19.	Roth Y, Tichler T, Kostenich G, et al. High-b-value diffusion-weighted MR imaging for pretreatment prediction and early monitoring of tumor response to therapy in mice [J]. Radiology, 2004; 232(3)∶685.
20.	Lyng H, Haraldseth O, Rofstad EK. Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging [J]. Magn Reson Med, 2000; 43(6)∶828.
21.	Yoshikawa T, Kawamitsu H, Mitchell DG, et al. ADC measurement of abdominal organs and lesions using parallel imaging technique [J]. AJR Am J Roentgenol, 2006; 187(6)∶1521.
22.	Taouli B, Vilgrain V, Dumont E, et al. Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients [J]. Radiology, 2003; 226(1)∶71.
23.	Sinha S, Lucas-Quesada FA, Sinha U, et al. In vivo diffusion-weighted MRI of the breast: potential for lesion characterization [J]. J Magn Reson Imaging, 2002; 15(6)∶693.
24.	Katayama M, Masui T, Kobayashi S, et al. Diffusion-weighted echo planar imaging of ovarian tumors: is it useful to measure apparent diffusion coefficients? [J]. J Comput Assist Tomogr, 2002; 26(2)∶250.
25.	任莹, 金征宇, 冯逢, 等. 3.0T磁共振扩散加权成像对胰腺癌的诊断价值初探 [J]. 中国医学影像技术, 2006; 22(4) ∶581.
26.	Ichikawa T, Haradome H, Hachiya J, et al. Diffusion-weighted MR imaging with single-shot echo-planar imaging in the upper abdomen: preliminary clinical experience in 61 patients [J]. Abdom Imaging, 1999; 24(5)∶456.
27.	Ichikawa T, Erturk SM, Motosugi U, et al. High-b value diffusion-weighted MRI for detecting pancreatic adenocarcinoma: preliminary results [J]. AJR Am J Roentgenol, 2007; 188(2)∶409.
28.	Hosten N, Lemke AJ, Wiedenmann B, et al. Combined imaging techniques for pancreatic cancer [J]. Lancet, 2000; 356(9233)∶909.
29.	Tajima Y, Kuroki T, Tsutsumi R, et al. Pancreatic carcinoma coexisting with chronic pancreatitis versus tumor-forming pancreatitis: diagnostic utility of the time-signal intensity curve from dynamic contrast-enhanced MR imaging [J]. World J Gastroenterol, 2007; 13(6)∶858.
30.	吴苾，宋彬. 影像学新技术在消化系统的临床应用 [J]. 中国普外基础与临床杂志， 2007； 14（2）∶222.

1. 　Steer ML, Waxman I, Freedman S. Chronic pancreatitis [J]. N Engl J Med, 1995; 332(22)∶1482.
2. 　葛春林，郭克建. 胰腺癌可切除性的判断 [J]. 中国普外基础与临床杂志， 2003； 10（6）∶526.
3. 　Niederau C, Grendell JH. Diagnosis of pancreatic carcinoma. Imaging techniques and tumor markers [J]. Pancreas, 1992; 7(1)∶66.
4. 　Gudjonsson B, Livstone EM, Spiro HM. Cancer of the pancreas: diagnostic accuracy and survival statistics [J]. Cancer, 1978; 42(5)∶2494.
5. 　宋彬, 闵鹏秋, 吴苾, 等. 磁共振VIBE序列鉴别胰腺癌与肿块型慢性胰腺炎的价值探讨 [J]. 放射学实践, 2006; 21(51)∶498.
6. 　Henriksen O. MR spectroscopy in clinical research [J]. Acta Radiol, 1994; 35(2)∶96.
7. 　Cho SG, Lee DH, Lee KY, et al. Differentiation of chronic focal pancreatitis from pancreatic carcinoma by in vivo proton magnetic resonance spectroscopy [J]. J Comput Assist Tomogr, 2005; 29(2)∶163.
8. 　Kim T, Murakami T, Takamura M, et al. Pancreatic mass due to chronic pancreatitis: correlation of CT and MR imaging features with pathologic findings [J]. AJR Am J Roentgenol, 2001; 177(2)∶367.
9. 　Cho SG, Kim YS, Kim HJ, et al. Chronic hepatitis: in vivo proton MR spectroscopic evaluation of the liver and correlation with histopathologic findings [J]. Radiology, 2001; 221(3)∶740.
10. 　Kaplan O, Kushnir T, Askenazy N, et al. Role of nuclear magnetic resonance spectroscopy (MRS) in cancer diagnosis and treatment: 31P, 23Na, and 1H MRS studies of three models of pancreatic cancer [J]. Cancer Res, 1997; 57(8)∶1452.
11. 　Wright CE, Tallan HH, Lin YY, et al. Taurine: biological update [J]. Annu Rev Biochem, 1986; 55∶427.
12. 　Moreno A, Rey M, Montane JM, et al. 1H NMR spectroscopy of colon tumors and normal mucosal biopsies; elevated taurine levels and reduced polyethyleneglycol absorption in tumors may have diagnostic significance [J]. NMR Biomed, 1993; 6(2)∶111.
13. 　Remy C, Arus C, Ziegler A, et al. In vivo, ex vivo, and in vitro one- and two-dimensional nuclear magnetic resonance spectroscopy of an intracerebral glioma in rat brain: assignment of resonances [J]. J Neurochem, 1994; 62(1)∶166.
14. 　Chemin-Thomas C, Palévody C, Esclassan J, et al. Combined magnetic resonance imaging and spectrometry for characterization of human pancreatic adenocarcinoma (Capan-1) heterotransplanted in nude mice [J]. Gastroenterol Clin Biol, 1994; 18(10)∶859.
15. 　Khan SA, Cox IJ, Thillainayagam AV, et al. Proton and phosphorus-31 nuclear magnetic resonance spectroscopy of human bile in hepatopancreaticobiliary cancer [J]. Eur J Gastroenterol Hepatol, 2005; 17(7)∶733.
16. 　Pierpaoli C, Righini A, Linfante I, et al. Histopathologic correlates of abnormal water diffusion in cerebral ischemia: diffusion-weighted MR imaging and light and electron microscopic study [J]. Radiology, 1993; 189(2)∶439.
17. 　邢悦，刘荣波. 肝脏磁共振弥散加权成像的研究进展 [J]. 中国普外基础与临床杂志， 2007； 14（3）∶359.
18. 　杨洋，宋彬，吴苾. 慢性病毒性肝炎组织病理学分级和磁共振弥散成像的对照研究 [J]. 中国普外基础与临床杂志， 2006； 13（4）∶469.
19. 　Roth Y, Tichler T, Kostenich G, et al. High-b-value diffusion-weighted MR imaging for pretreatment prediction and early monitoring of tumor response to therapy in mice [J]. Radiology, 2004; 232(3)∶685.
20. 　Lyng H, Haraldseth O, Rofstad EK. Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging [J]. Magn Reson Med, 2000; 43(6)∶828.
21. 　Yoshikawa T, Kawamitsu H, Mitchell DG, et al. ADC measurement of abdominal organs and lesions using parallel imaging technique [J]. AJR Am J Roentgenol, 2006; 187(6)∶1521.
22. 　Taouli B, Vilgrain V, Dumont E, et al. Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients [J]. Radiology, 2003; 226(1)∶71.
23. 　Sinha S, Lucas-Quesada FA, Sinha U, et al. In vivo diffusion-weighted MRI of the breast: potential for lesion characterization [J]. J Magn Reson Imaging, 2002; 15(6)∶693.
24. 　Katayama M, Masui T, Kobayashi S, et al. Diffusion-weighted echo planar imaging of ovarian tumors: is it useful to measure apparent diffusion coefficients? [J]. J Comput Assist Tomogr, 2002; 26(2)∶250.
25. 　任莹, 金征宇, 冯逢, 等. 3.0T磁共振扩散加权成像对胰腺癌的诊断价值初探 [J]. 中国医学影像技术, 2006; 22(4) ∶581.
26. 　Ichikawa T, Haradome H, Hachiya J, et al. Diffusion-weighted MR imaging with single-shot echo-planar imaging in the upper abdomen: preliminary clinical experience in 61 patients [J]. Abdom Imaging, 1999; 24(5)∶456.
27. 　Ichikawa T, Erturk SM, Motosugi U, et al. High-b value diffusion-weighted MRI for detecting pancreatic adenocarcinoma: preliminary results [J]. AJR Am J Roentgenol, 2007; 188(2)∶409.
28. 　Hosten N, Lemke AJ, Wiedenmann B, et al. Combined imaging techniques for pancreatic cancer [J]. Lancet, 2000; 356(9233)∶909.
29. 　Tajima Y, Kuroki T, Tsutsumi R, et al. Pancreatic carcinoma coexisting with chronic pancreatitis versus tumor-forming pancreatitis: diagnostic utility of the time-signal intensity curve from dynamic contrast-enhanced MR imaging [J]. World J Gastroenterol, 2007; 13(6)∶858.
30. 　吴苾，宋彬. 影像学新技术在消化系统的临床应用 [J]. 中国普外基础与临床杂志， 2007； 14（2）∶222.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Differentiation of Chronic Mass-Forming Type Pancreatitis from Pancreatic Carcinoma by Functional Magnetic Resonance Imaging

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