Relationship Between Strong Immunoreactivity of Focal Adhesion Kinase and Invasion and Metastasis in Human Gastric Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Duoqiang ¹ , LI Yumin ¹ , HE Xiaodong ² , ZHOU Wence ¹ , LI Xun ¹ , ZENG Feng ³ , YANG Lansheng. ³

Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China;

Corresponding author：

Keywords：

Focal adhesion kinase Gastric carcinoma Infiltration Metastasis

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【Abstract】Objective To study the correlation between focal adhesion kinase (FAK) expression and biological behavior of invasion and metastasis in gastric carcinoma.
MethodsThe immunoreactivity of FAK was revealed by immunohistochemical method in gastric carcinoma tissues,canceradjacent tissues, normal gastric mucosa,and 200 regional lymph nodes in 50 collected specimens when radical resection of gastric carcinoma were carried out.
ResultsThe percentage of FAK bly positive immunoreactivity were 10.0%（5/50）， 20.0%（10/50） and 78.0%（39/50） in normal gastric mucosa， cancer-adjacent tissues and gastric carcinoma tissues respectively. The b immunoreactivity was obviously higher in gastric carcinoma tissues than that in normal gastric mucosa or canceradjacent tissues (P＜0.01). There were no difference between normal gastric mucosa and canceradjacent tissues (P gt;0.05). The percentage of bly positive immunoreactivity of FAK were 68.8%（22/32） and 33.3%（6/18） in cases with metastasis and without metastasis of lymph node respectively. The immunoreactivity of FAK in cases with metastasis of lymph node was significantly higher than that without metastasis of lymph node (P＜0.05).The b immunoreactivity of FAK were 87.2%（136/156） and 40.9%(18/44) in withmetastatic lymph node and withoutmetastatic lymph node. The immunoreactivity of FAK in withmetastatic lymph node was significantly higher than that withoutmetastatic lymph node （P＜0.01）. The percentage of FAK bly positive immunoreactivity showed correlation with the cellular differentiation and depth of infiltration of gastric carcinoma. The deeper infiltration and lower differentiation, the ber expression rate was obtained (P＜0.05), which showed no correlation with Borrmann type, location and size of tumor (P gt;0.05).
ConclusionIncreased immunoreactivity of FAK is an important role of invasion and metastasis for gastric carcinoma cells. Detection of FAK expression in cancer tissues can be helpful to understand the carcinogenic biological behavior of gastric carcinoma as well as to make judgment and treatment of prognosis of patients.

Citation： ZHANG Duoqiang,LI Yumin,HE Xiaodong,ZHOU Wence,LI Xun,ZENG Feng,YANG Lansheng.. Relationship Between Strong Immunoreactivity of Focal Adhesion Kinase and Invasion and Metastasis in Human Gastric Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(1): 38-41. doi: Copy

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1. 许良中, 杨文涛. 免疫组织化学反应结果的判断标准 [Ｊ]. 中国癌症杂志, 1996; 6(4)∶229.
2. Su JM, Gui L, Zhou YP, et al. Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance [Ｊ]. World J Gastroenterol, 2002; 8(4)∶613.
3. Duxbury MS, Ito H, Zinner MJ, et al.Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells [Ｊ]. Surgery, 2004; 135(5)∶555.
4. Crowe DL, Ohannessian A. Recruitment of focal adhesion kinase and paxillin to beta1 integrin promotes cancer cell migration via mitogen activated protein kinase activation [Ｊ]. BMC Cancer, 2004; 4(1)∶18.
5. Wang H, Radjendirane V, Wary KK, et al. Transforming growth factor beta regulates cellcell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells [Ｊ]. Oncogene, 2004; 23(32)∶5558.
6. Zhang Y, Thant AA, Hiraiwa Y, et al.A role for focal adhesion kinase in hyluronandependent MMP2 secretion in a human smallcell lung carcinoma cell line, QG90 [Ｊ]. Biochem Biophys Res Commun, 2002; 290(3)∶1123.
7. Fujii T, Koshikawa K, Nomoto S, et al. Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor [Ｊ]. J Hepatol, 2004; 41(1)∶104.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Strong Immunoreactivity of Focal Adhesion Kinase and Invasion and Metastasis in Human Gastric Carcinoma

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