Expression of CD44v6 in Gastric Carcinoma and Its Clinical Significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XU Shengjun ¹ , HU Bingkui ² , LING Zhiqiang ³ , ZHAO Ting. ⁴

Department of Surgery, Shangyu Hospital of Traditional Chinese Medicine, Shangyu 312300, China;

Corresponding author：

Keywords：

Gastric carcinoma CD44v6 Metastasis Prognosis

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【Abstract】ObjectiveTo study the relationship between expression of CD44v6 in gastric carcinoma and neoplasm metastasis and prognosis.
MethodsExpression of CD44v6 in 52 cases of gastric carcinoma was assayed by flow immunocytometry, and its relation with clinical pathology and prognosis was analyzed.
ResultsIn 52 cases of gastric carcinoma tissue, the positive rate of CD44v6 expression was 67.31%(35/52); but the positive rate of CD44v6 expression in normal gastric tissue was 25.00% (13/52). The positive rate of expression was significantly different (P＜0.01). The positive rate of CD44v6 expression in gastric carcinoma tissues was related to the depth of carcinoma infiltration, lymph node metastasis and pTNM stage （P＜0.05）.
ConclusionExpression of CD44v6 plays an important role in invasion, metastasis and pTNM stage of gastric carcinoma. It may be used as a new indicator to predict metastatic potential and prognosis of gastric carcinoma.

Citation： XU Shengjun,HU Bingkui,LING Zhiqiang,ZHAO Ting.. Expression of CD44v6 in Gastric Carcinoma and Its Clinical Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(1): 42-44. doi: Copy

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7.	Koyama S, Maruyama T, Adachi S. Expression of epidermal growth factor receptor and CD44 splicing variants sharing exons 6 and 9 on gastric and esophageal carcinomas: a twocolor flowcytometric analysis [Ｊ]. J Cancer Res Clin Oncol, 1999; 125(1)∶47.
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1. Yamaguchi A, Goi T, Yu J, et al. Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and longterm prognosis [Ｊ]. J Surg Oncol, 2002; 79(4)∶230.
2. Xin Y, Grace A, Gallagher MM, et al. CD44V6 in gastric carcinoma: a marker of tumor progression [Ｊ]. Appl Immunohistochem Mol Morphol, 2001; 9(2)∶138.
3. Stachura J, Krzeszowiak A, Popiela T, et al. Preferential overexpression of CD44v5 in advanced gastric carcinoma Goseki grades Ⅰ and Ⅲ [Ｊ]. Pol J Pathol, 1999; 50(3)∶155.
4. Van Driel M, Gunthert U, van Kessel AC, et al. CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells [Ｊ]. Leukemia, 2002; 16(1)∶135.
5. Gulmann C, Grace A, Leader M, et al. CD44v6: a potential marker of malignant transformation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays [Ｊ]. Eur J Gastroenterol Hepatol, 2003; 15(9)∶981.
6. Joo M, Lee HK, Kang YK. Expression of Ecadherin, betacatenin, CD44s and CD44v6 in gastric adenocarcinoma: relationship with lymph node metastasis [Ｊ]. Anticancer Res, 2003; 23(2B)∶1581.
7. Koyama S, Maruyama T, Adachi S. Expression of epidermal growth factor receptor and CD44 splicing variants sharing exons 6 and 9 on gastric and esophageal carcinomas: a twocolor flowcytometric analysis [Ｊ]. J Cancer Res Clin Oncol, 1999; 125(1)∶47.
8. Nakashio T, Narita T, Sato M, et al. The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer [Ｊ]. Anticancer Res, 1997; (1A)∶293.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of CD44v6 in Gastric Carcinoma and Its Clinical Significance

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