• Center of Gastrointestinal Surgery, Affiliated Union Hospital, Tongji Medical College, Huangzhong Science and Technology University, Wuhan 430022, China;
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【Abstract】ObjectiveTo inquire into the regulative effect of interferon (IFN) on human leucocyte antigen-DR(HLADR) expression in human colonic cancer cells.
MethodsThe expression of HLA-DR in 4 colonic cancer cell lines HCT-8,lovo,SW-480 and Ls-174-T was detected with immunohistochemical SP and ELISA method before and after being stimulated by different doses of α-IFN or γ-IFN.
ResultsAll cell lines except lovo cell were HLA-DR positive before stimulation with α-IFN or γ-IFN. HLA-DR expression was enhanced on all of the 4 cell lines after stimulation, and it was correlated with γ-IFN and the dose of γ-IFN. The effect of γ-IFN was more obvious than that of α-IFN.
ConclusionIFN can enhance HLA-DR expression in human colonci cancer cells and clinical therapy of IFN for colon cancer has a certain applying prospect.

Citation: HUANG Wenguang,LIU Gang,FANG Quan,HUANG Hanju.. Effect of Interferon on Human Leucocyte Antigen-DR Expression in Human Colonic Cancer Cells. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(1): 15-18. doi: Copy