【Abstract】ObjectiveTo investigate the risk factors for acute lung injury(ALI) after orthotopic liver transplantation(OLT) and to explore the prevention and cure scheme.
MethodsThe risk factors responsible for ALI in 4 patients undergoing OLT were analyzed with retrospective investigation.
ResultsPortal pulmonary hypertension, longterm mechanical ventilation, severe infection, SIRS, hypercoagulability, overdose transfusion and kidney dysfunction were risk factors for ALI.
ConclusionALI frequently occurred after OLT. Reducing and diminishing the risk factors is very important to avoid ALI after OLT.
Citation：
SHI Bin,LI Yumin,LI Xun,ZHOU Wence,YANG Qingping,CAO Nong.. Risk Factors for Acute Lung Injury after Liver Transplantation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(1): 63-66. doi:
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- 1. 郑树森主编.肝脏移植 [M]. 第1版. 北京: 人民卫生出版社, 2001∶540～542.
- 2. 朱士俊主编.现代医院感染学 [M]. 第1版.北京: 人民军医出版社, 1998∶7～82.
- 3. 刘大为主编.危重病学分册（二十一世纪医师丛书） [M]. 第1版. 北京： 中国协和医科大学出版社， 2000∶144～152.
- 4. 黎鳌主编.创伤后脏器功能不全 [M]. 第1版.石家庄： 河北科学技术出版社，1999∶35～75.
- 5. 景华主编.实用外科重症监护与治疗 [M]. 第1版.上海： 第二军医大学出版社，1999∶251～252.
- 6. Kuo P. Pulmonary hypertension: consideration in the liver transplant candidate [J]. Transplant Int, 1996； 9（2）∶141.
- 7. Roland Schott,Ari Chaouat, Anne Launoy, et al. Improvement of pulmonary hypertension after liver transplantation [J]. Chest, 1999； 115(6)∶1748.
- 8. 段敏. 肝脏移植患者术后肺部感染的危险因素分析 [J]. 中华护理杂志， 2002； 37(8)∶4.
- 9. 王彦,王宝恩,张淑文.多脏器功能失常综合症患者肺功能受损的动态分析 [J]. 中国危重病急救医学， 1999； 11 (2) ∶115.
- 10. Meduri GU. Clinical review: a paradigm shift: the bidirectional effect of inflammation on bacterial growth. Clinical implications for patients with acute respiratory distress syndrome [J]. Crit Care, 2002; 6(1)∶24.
- 11. Taura P, GarciaValdecasas JC, Beltran J, et al. Moderate primary pulmonary hypertension in patients undergoing liver transplantation [J]. Anesth Analg， 1996； 83（4）∶675.
- 12. Nakazawa K, Uchida T, Matsuzawa Y,et al. Treatment of pulmonary hypertension and hypoxia due to oleic acid induced lung injury with intratracheal prostaglandin E1 during partial liquid ventilation [J]. Anesthesiology, 1998; 89(3)∶686.
- 13. Abraham E. Coagulation abnormalities in acute lung injury and sepsis [J]. Am J Respir Cell Mol Biol, 2000； 22(4)∶401.
- 14. Vincent JL. New therapeutic implications of anticoagulation mediator replacement in sepsis and acute respiratory distress syndrome [J]. Crit Care Med, 2000； 28（9 Suppl）∶S83.
- 15. Attanasio M,Gori AM, Giusti B,et al. Cytokines gene expression in human stimulated monocytes is inhibited by heparin [J]. Thromb Haemost, 1997； 77（Suppl）∶9.
- 16. Bernard GR, Artigas A, Brigham KL, et al. The American European consensus conference on acute respiratory distress syndrome: definitions, mechanisms, and relevant outcomes, clinical trial coordination [J]. Am J Respir Crit Care Med, 1994; 149(3)∶818.
