Objective To evaluate the value of 99Tcm-Octreotide somatostatin receptor and 99Tcm-MIBI imaging in the detection of breast cancer.
Methods 99Tcm-Octreotide and 99Tcm-MIBI imaging were performed in 26 patients with breast masses before operation. The scintigraphy results were analysed compared with pathologic study.
Results The sensitivity, specificity and accuracy of 99Tcm-Octreotide scintigraphy for breast cancer were 94.4%, 87.5% and 92.3% respectively and those of 99Tcm-MIBI were 88.9%, 75.0% and 84.6% respectively. Significant difference was found between 99Tcm-Octreotide and 99Tcm-MIBI in both of specificity and accuracy (P＜0.05 and P＜0.01). The sensitivity, specificity and accuracy of 99Tcm-Octreotide scintigraphy in the detection of axillary lymph node involvement were 66.7%, 92.9% and 80.8% respectively. Those of 99Tcm-MIBI were 58.3%, 85.7% and 73.1% respectively. The specificity showed significant difference between 99Tcm-Octreotide and 99Tcm-MIBI (P＜0.01).
Conclusion 99Tcm-Octreotide somatostatin receptor imaging may be superior to 99Tcm-MIBI in the detection of primary breast cancer and axillary lymph node involvement, and 99Tcm-Octreotide scintigraphy before operation is helpful in working out operative modality for patients.
Citation：
DENG Nianying,ZHANG Jinshan,XIAN Youqing. Clinical Application of 99Tcm-Octreotide and 99Tcm-MIBI Imaging in the Diagnosis of Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(1): 17-19. doi:
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- 3. 鸿文. 99Tcm标记生长抑素类似物作为受体显像及特异性研究 [Ｊ]. 国外医学放射核医学分册, 1998； 22(4)∶158.
- 4. Cuntz MC, Levine EA, O’Dorisio TM, et al. Intraoperative gamma detection of 125I-lanreotide in women with primary breast cancer [Ｊ]. Ann Surg Oncol, 1999; 6(4)∶367.
- 5. Skanbcrg J, Ahlman H, Bcnjcgard SA, et al. Indiu-111-Octrcotidc scintigraply intraopcrativc gamma-delectorlocalisation and somatostatin receptor expression in primary haman breast cancer [Ｊ]. Breast Cancer Res Treat, 2002; 74(2)∶101.
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