Relation Between CD44v6 and Lymph Node Metastasis and Prognosis of Gastric Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XIA Jianguo , YANG Li , CHEN Guoyu

Department of General Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China;

Corresponding author：

Keywords：

Gastric carcinoma; CD44v6; Metastasis; Prognosis

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Objective To investigate the relation between CD44v6 and lymph node metastasis and prognosis of gastric carcinoma.
Methods The expression of CD44v6 in 100 cases of advanced human gastric carcinoma was detected by immunohistochemical twostep method. Its relation with clinical pathology and prognosis was analyzed.
Results CD44v6 expression occurred in 64%(64/100) of all gastric carcinomas; with the increase of depth of cancer invasion and local lymph node metastasis, the expression of CD44v6 elevated.
Conclusion CD44v6 plays an important role in lymph node metastasis of human gastric carcinoma. It may be used as a new indicator to predict metastatic potential and prognosis of gastric carcinoma.

Citation： XIA Jianguo,YANG Li,CHEN Guoyu. Relation Between CD44v6 and Lymph Node Metastasis and Prognosis of Gastric Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(2): 107-109. doi: Copy

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1. 陈江，张振玉，祝金泉，等. CD44v6蛋白在胃癌中表达及其临床意义 [J]. 临床与实验病理学杂志， 1998； 14（5）∶440.
2. Yamaguchi A, Goi T, Yu J, et al. Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and longterm prognosis [J]. J Surg Oncol， 2002; 79(4)∶230.
3. Gunthert U, Hofmann M, Rudy W, et al. A new variant of glycoprotein CD44 cofers metastatic potential to rat carcinoma cells [J]. Cell, 1991; 65(1)∶13.
4. Yamamichi K, Uehara Y, Kitamura N, et al. Increased expression of CD44v6 mRNA significantly correlates with distant metastasis and poor prognosis in gastric cancer [J]. Int J Cancer, 1998； 79(3)∶256.
5. Saito H, Tsujitani S, Katano K, et al. Serum concentration of CD44 variant 6 and its relation to prognosis in patients with gastric carcinoma [J]. Cancer, 1998； 83(6)∶1094.
6. Adachi Y, Suematsu T, Shiraish N, et al. Perigastric lymph node status as a prognostic indicator in patients with gastric cancer [J]. Br J Surg, 1998; 85(9)∶1281.
7. 金卫中，杨东慧，赵景轩, 等. nm23、CD44H和CD44v6蛋白在胃癌的表达及意义 [J]. 中国普外基础与临床杂志， 2000； 7（3）∶141.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relation Between CD44v6 and Lymph Node Metastasis and Prognosis of Gastric Carcinoma

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