Comparison of the Change of T-Lymphocyte Subsets and Immunoglobulin in Postoperative Gastric Carcinoma Patients with Regional Intra-Artery Implantation Pump Chemotherapy Versus Peripheral Venous Chemotherapy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Bo ¹ , PU Yongdong ¹ , JIANG Chenglai ² , LIN Gang ¹ , HE Jianmiao ¹ , DONG Liguo ¹ , ZHU Zhidong ¹

Department of General Surgery, The 309th Hospital of PLA, Beijing 100091, China;

Corresponding author：

Keywords：

Gastric carcinoma; Chemotherapy; T-lymophocyte subsets; Immunoglobulin

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Objective To observe the turbulence of regional intra-artery implantation chemotherapy and peripheral venous chemotherapy on immunologic function of patients.
Methods Two weeks after radical operation of gastric carcinoma, chemotherapy was performed. Eighty-three patients were divided into two groups, one (42 patients) received peripheral venous chemotherapy (PVC) and the other (41 patients) received regional intra-artery implantation pump chemotherapy (RAIPC). The serum T-lymphocyte subsets and immunoglobulin level before and 1-4 days after the chemotherapy were measured.
Results After PVC, proportion of CD3 and CD4, CD4/CD8 and IgG, IgA, IgM concentration in PVC group were significantly decreased compared with those before PVC （P＜0.05， P＜0.01）, and it is the same when compared with postRAIPC patients except for CD4 and IgM （P＜0.05）. In RAIPC group, there were no significant changes in proportion of CD3, CD4 and CD8, CD4/CD8 and IgG, IgA concentration between pre- and post-RAIPC patients.
Conclusion After radical operation of gastric carcinoma, RAIPC affects the immunologic function more moderate than PVC.

Citation： YANG Bo,PU Yongdong,JIANG Chenglai,LIN Gang,HE Jianmiao,DONG Liguo,ZHU Zhidong. Comparison of the Change of T-Lymphocyte Subsets and Immunoglobulin in Postoperative Gastric Carcinoma Patients with Regional Intra-Artery Implantation Pump Chemotherapy Versus Peripheral Venous Chemotherapy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(2): 110-112. doi: Copy

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3. 赵吉生，郑泽霖，郑扶民. 胃网膜动脉插管区域性化疗治疗晚期胃癌 [J]. 中国普外基础与临床杂志， 1998； 5（1）∶43.
4. 蒲永东，朱志东，何建苗，等. 超选择靶区动脉置泵综合治疗晚期胃肠道肿瘤 [J]. 中华外科杂志， 2002； 40（1）∶37.
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10. 蒋晓红，王民生. 博莱霉素致大鼠外周血淋巴细胞DNA损伤的研究 [J]. 江苏医药， 1998； 24（4）∶封三.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Comparison of the Change of T-Lymphocyte Subsets and Immunoglobulin in Postoperative Gastric Carcinoma Patients with Regional Intra-Artery Implantation Pump Chemotherapy Versus Peripheral Venous Chemotherapy

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