Current Situations and Prospects in the Biotherapy of Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHU Jinming , YU Peiwu

Department of General Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China;

Corresponding author：

Keywords：

Gastric cancer; Biotherapy

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To generally analyse the current situations and advances in the biotherapy of gastric cancer.
Methods The published papers about the current situations and research advances in the biotherapy of gastric cancer were reviewed.
Results The main research fields and treatments in the biotherapy of gastric cancer include immunomodulator therapy, guided therapy of monoclonal antibodies and their jointbodies, cytokine therapy, adoptive immunotherapy and gene therapy, etc.
Conclusion As a beneficial complement for surgery, chemotherapy and radiotherapy, biotherapy plays an important auxiliary role in the multiple treatments for gastric cancer.

Citation： ZHU Jinming,YU Peiwu. Current Situations and Prospects in the Biotherapy of Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(2): 127-129. doi: Copy

1.	Jung YD, Mansfield PF, Akagi M, et al. Effects of combination antivascular endothelial growth factor receptor and antiepidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model [J]. Eur J Cancer, 2002; 38(8)∶1133.
2.	Matsumoto K, Konno H, Tanaka T, et al. Combination therapy with vascular endothelial growth factor neutralizing antibody and mitomycin C on human gastric cancer xenograft [J]. Jpn JCancer Res, 2000; 91(7)∶748.
3.	Sasaki S, Ozeki I, Takekawa M, et al. Antibody treatment for cancer [J]. Nippon Geka Gakkai Zasshi, 2000; 101(9)∶607.
4.	Parmiani G, Rivoltini L, Andreola G, et al. Cytokines in cancer therapy [J]. Immunol Lett, 2000; 74(1)∶41.
5.	Penichet ML, Morrison SL. Antibodycytokine fusion proteins for the therapy of cancer [J]. J Immunol Methods, 2001; 248(1-2)∶91.
6.	Yamaue H, Tanimura H, Mizobata S, et al. Multidisciplinary treatment for gastric cancer patients by chemoimmunotherapy [J]. Hepatogastroenterology, 1999; 46(25)∶620.
7.	Yamaguchi Y, Ohta K, Shimizu K, et al. Generation of cytotoxic effector lymphocytes by MLTC using tumor cells genetically modified to secrete interleukin2 [J].Anticancer Res, 2001; 21(1B)∶669.
8.	Tsunoda T, Tanimura H, Yamaue H, et al. Tumor specific CTL therapy for advanced cancer and development for cancer vaccine [J]. Hepatogastroenterology, 1999; 46（Suppl 1）∶1287.
9.	Banchereau J, Steinman RM. Dendritic cells and the control of immunity [J]. Nature, 1998; 392(6673)∶245.
10.	Nair SK, Morse M, Boczkowski D, et al. Induction of tumorspecific cytotoxic T lymphocytes in cancer patients by autologous tumor RNAtransfected dendritic cells [J].Ann Surg, 2002; 235(4)∶540.
11.	孙黎飞, 刘江, 曹雪涛, 等. IL2基因修饰增强树突状细胞抗原提呈功能及其机制 [J]. 中华血液学杂志, 2002; 23(5)∶247.
12.	章卫平, 何龙, 曹雪涛. 淋巴细胞趋化因子基因修饰增强肿瘤抗原多肽致敏的树突状细胞的抗肿瘤免疫效果 [J]. 中华医学杂志, 1999; 79(3)∶170.
13.	Gong J, Avigan D, Chen D, et al. Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells [J]. Proc Natl Acad Sci USA, 2000; 97(6)∶2715.
14.	Pulendran B, Lingappa J, Kennedy MK, et al. Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice [J]. J Immunol, 1997; 159(5)∶2222.
15.	Yi Q, Desikan R, Barlogie B, et al. Optimizing dendritic cellbased immunotherapy in multiple myeloma [J]. Br J Haematol, 2002; 117(2)∶297.
16.	余文林, 黄宗海. 自杀基因治疗胃肠道肿瘤的研究进展 [J]. 中国普外基础与临床杂志, 1999; 6(3)∶781.
17.	Naka K, Yokozaki H, Yasui W, et al. Effect of antisense human telomerase RNA transfection on the growth of human gastric cancer cell lines [J]. Biochem Biophys Res Commun, 1999; 255(3)∶753.
18.	Steele RJ, Lane DP. Gene therapy for gastric cancer: problems and prospects [J]. Surg Oncol, 2000; 9(1)∶13.
19.	Vile RG, Russell SJ, Lemoine NR. Cancer gene therapy: hard lessons and new courses [J]. Gene Ther, 2000; 7(1)∶2.
20.	钱其军, 车小燕, 岑信棠, 等. 基因病毒载体的研制及其抗肿瘤作用的初步研究 [J]. 中华医学杂志, 2002; 82(8)∶557.
21.	Smith ER, Chiocca EA. Oncolytic viruses as novel anticancer agents: turning one scourge against another [J]. Expert Opin Investig Drugs, 2000; 9(2)∶311.
22.	Hermiston T. Gene delivery from replicationselective viruses: arming guided missiles in the war against cancer [J]. J Clin Invest, 2000; 105(9)∶1169.
23.	Kim R, Minami K, Nishimoto N, et al. Enhancement of antitumor effect by intratumoral administration of bax gene in combination with anticancer drugs in gastric cancer [J]. Int J Oncol, 2001; 18(2)∶363.
24.	刘君, 李宁, 宋少柏. 胃癌的分子生物学研究进展 [J]. 中国普外基础与临床杂志, 2000; 7(3)∶791.
25.	Mologni L, Marchesi E, Nielsen PE, et al. Inhibition of promyelocytic leukemia (PML)/retinoic acid receptoralpha and PML expression in acute promyelocytic leukemia cells by antiPML peptide nucleic acid [J]. Cancer Res, 2001; 61(14)∶5468.

1. Jung YD, Mansfield PF, Akagi M, et al. Effects of combination antivascular endothelial growth factor receptor and antiepidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model [J]. Eur J Cancer, 2002; 38(8)∶1133.
2. Matsumoto K, Konno H, Tanaka T, et al. Combination therapy with vascular endothelial growth factor neutralizing antibody and mitomycin C on human gastric cancer xenograft [J]. Jpn JCancer Res, 2000; 91(7)∶748.
3. Sasaki S, Ozeki I, Takekawa M, et al. Antibody treatment for cancer [J]. Nippon Geka Gakkai Zasshi, 2000; 101(9)∶607.
4. Parmiani G, Rivoltini L, Andreola G, et al. Cytokines in cancer therapy [J]. Immunol Lett, 2000; 74(1)∶41.
5. Penichet ML, Morrison SL. Antibodycytokine fusion proteins for the therapy of cancer [J]. J Immunol Methods, 2001; 248(1-2)∶91.
6. Yamaue H, Tanimura H, Mizobata S, et al. Multidisciplinary treatment for gastric cancer patients by chemoimmunotherapy [J]. Hepatogastroenterology, 1999; 46(25)∶620.
7. Yamaguchi Y, Ohta K, Shimizu K, et al. Generation of cytotoxic effector lymphocytes by MLTC using tumor cells genetically modified to secrete interleukin2 [J].Anticancer Res, 2001; 21(1B)∶669.
8. Tsunoda T, Tanimura H, Yamaue H, et al. Tumor specific CTL therapy for advanced cancer and development for cancer vaccine [J]. Hepatogastroenterology, 1999; 46（Suppl 1）∶1287.
9. Banchereau J, Steinman RM. Dendritic cells and the control of immunity [J]. Nature, 1998; 392(6673)∶245.
10. Nair SK, Morse M, Boczkowski D, et al. Induction of tumorspecific cytotoxic T lymphocytes in cancer patients by autologous tumor RNAtransfected dendritic cells [J].Ann Surg, 2002; 235(4)∶540.
11. 孙黎飞, 刘江, 曹雪涛, 等. IL2基因修饰增强树突状细胞抗原提呈功能及其机制 [J]. 中华血液学杂志, 2002; 23(5)∶247.
12. 章卫平, 何龙, 曹雪涛. 淋巴细胞趋化因子基因修饰增强肿瘤抗原多肽致敏的树突状细胞的抗肿瘤免疫效果 [J]. 中华医学杂志, 1999; 79(3)∶170.
13. Gong J, Avigan D, Chen D, et al. Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells [J]. Proc Natl Acad Sci USA, 2000; 97(6)∶2715.
14. Pulendran B, Lingappa J, Kennedy MK, et al. Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice [J]. J Immunol, 1997; 159(5)∶2222.
15. Yi Q, Desikan R, Barlogie B, et al. Optimizing dendritic cellbased immunotherapy in multiple myeloma [J]. Br J Haematol, 2002; 117(2)∶297.
16. 余文林, 黄宗海. 自杀基因治疗胃肠道肿瘤的研究进展 [J]. 中国普外基础与临床杂志, 1999; 6(3)∶781.
17. Naka K, Yokozaki H, Yasui W, et al. Effect of antisense human telomerase RNA transfection on the growth of human gastric cancer cell lines [J]. Biochem Biophys Res Commun, 1999; 255(3)∶753.
18. Steele RJ, Lane DP. Gene therapy for gastric cancer: problems and prospects [J]. Surg Oncol, 2000; 9(1)∶13.
19. Vile RG, Russell SJ, Lemoine NR. Cancer gene therapy: hard lessons and new courses [J]. Gene Ther, 2000; 7(1)∶2.
20. 钱其军, 车小燕, 岑信棠, 等. 基因病毒载体的研制及其抗肿瘤作用的初步研究 [J]. 中华医学杂志, 2002; 82(8)∶557.
21. Smith ER, Chiocca EA. Oncolytic viruses as novel anticancer agents: turning one scourge against another [J]. Expert Opin Investig Drugs, 2000; 9(2)∶311.
22. Hermiston T. Gene delivery from replicationselective viruses: arming guided missiles in the war against cancer [J]. J Clin Invest, 2000; 105(9)∶1169.
23. Kim R, Minami K, Nishimoto N, et al. Enhancement of antitumor effect by intratumoral administration of bax gene in combination with anticancer drugs in gastric cancer [J]. Int J Oncol, 2001; 18(2)∶363.
24. 刘君, 李宁, 宋少柏. 胃癌的分子生物学研究进展 [J]. 中国普外基础与临床杂志, 2000; 7(3)∶791.
25. Mologni L, Marchesi E, Nielsen PE, et al. Inhibition of promyelocytic leukemia (PML)/retinoic acid receptoralpha and PML expression in acute promyelocytic leukemia cells by antiPML peptide nucleic acid [J]. Cancer Res, 2001; 61(14)∶5468.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Current Situations and Prospects in the Biotherapy of Gastric Cancer

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