Establishment and Assessment of Rat Model of Postoperative Fatigue Syndrome_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Jianxin ¹ , DENG Shigui ² , YANG Ming ¹ , QIU Xinfan ³ , ZHANG Liutong. ³

Department of General Surgery, The Second Affiliated Hospital, Guangzhou University of TCM, Guangzhou 510120, China;

Corresponding author：

Keywords：

Postoperation fatigue syndrome Rat Animal model Resection of liver Gene expression

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【Abstract】Objective To establish and assess the rat model of postoperative fatigue syndrome (POFS).
Methods The rat model of POFS was developed by the partial resection of the liver. The behavioral changes prior and post to operation, the disorder of nutritive intake after operation, stress reaction (pathological changes of mucous membrane in small intestine) and the hepatic albumin gene expression were observed.
Results Low body temperature, lower sensitivity and reactivity were found. The serum levels of the iron, total protein, albumin, globulin and so on as the indexes of nutrition obviously dropped. The injury of the mucous membrane resulted from the stress reaction after the resection of the liver. The gene expression of the albumin decreased in the model group.
Conclusion The experimental rat model of POFS by partial resection of the liver can be used for the investigation of POFS.

Citation： YANG Jianxin,DENG Shigui,YANG Ming,QIU Xinfan,ZHANG Liutong.. Establishment and Assessment of Rat Model of Postoperative Fatigue Syndrome. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(5): 424-427. doi: Copy

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1. Rubin GJ, Hotopf M. Systematic review and metaanalysis of interventions for postoperative fatigue [Ｊ]. Br J Surg， 2002; 89(8)∶ 971.
2. Christensen T, Hougard F, Kehlet H. Influence of pre and intra operative factors on the occurrence of postoperative fatigue [Ｊ]. Br J Surg， 1985; 72(1)∶63.
3. Christensen T, Kehlet H. Postoperative fatigue [Ｊ]. World J Surg， 1993; 17(2)∶220.
4. Higgins GM, Anderson RM. Experimental pathology of the liver [Ｊ]. Arch Pathol, 1931; 12（2）∶186.
5. 陈长勋，金若敏，李仪奎，等. 正常SD大鼠的部分生物数据测定 [Ｊ]. 动物学杂志， 1996； 31（4）∶19.
6. 陈平，李昆，董家鸿. 肝硬变大鼠肝部分切除术动物模型的制作方法 [Ｊ]. 第三军医大学学报， 2002； 24（4）∶488.
7. 王天芳，陈易新，季绍良，等. 慢性束缚致慢性疲劳动物模型的研制及其行为学观察 [Ｊ]. 中国中医基础医学杂志， 1999； 5（5）∶25.
8. 艾华. 力竭性游泳对大鼠睾丸金属结合蛋白的诱导及其与睾酮和锌的关系 [Ｊ]. 中国应用生理学杂志， 1994； 10（2）∶117.
9. Muller AR, Langrehr JM, Nalesnik M, et al. Mucosal glutaminase activity and histology as parameters of small bowel preservation injury [Ｊ]. J Surg Res, 1994; 56(3)∶207.
10. Chomczynski P, Sacchi N. Singlestep method of RNA isolation by acid guanidinium thiocyanatephenolchloroform extraction [Ｊ]. Anal Biochem， 1987; 162(1)∶156.
11. 毛争春，陈如坤，赵琳. 重组人生长激素对心脏手术后疲劳综合征的影响 [Ｊ]. 中华医学杂志， 2002； 829（11）∶267.
12. 李雅慧，贾汝梅，王景顺，等. 1 002例普通外科择期手术住院患者营养状态评价 [Ｊ]. 中国临床营养杂志， 2002； 3（1）∶4.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Establishment and Assessment of Rat Model of Postoperative Fatigue Syndrome

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