XIONG Jinwen , SHEN Wenl , CHEN Gengzhen , WEN Jun , LIU Shaojie.
  • Department of General Surgery, The Second Affiliated Hospital, Shantou University, Shantou 515041, China;
Acute necrotizing pancreatitis Sanqizonggan Treatment Bacterial translocation
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【Abstract】Objective  To study the effects of Chinese traditional medicine Sanqizonggan on bacterial translocation in rats with acute necrotizing pancreatitis (ANP).
Methods  The rat model of ANP was established by retrograde bilepancreatic duct injection of 5% sodium taurocholate. All rats were randomly divided into three groups: the shamoperation group(n=30), ANP group(n=30), and ANP+Chinese traditional medicine group (n=30). The serum amylase was detected at 0 h,12 h,24 h, and oneweek survival rate and pancreatic histological changes were observed in three groups, and the bacterial translocation from intestinal lumen was examined.
Results  The survival rate of the group treated with Chinese traditional medicine was significantly higher than that of the ANP group. The rate of bacterial translocation in the treated group significantly decreased.
Conclusion  The Chinese traditional medicine Sanqizonggan can promote gastrointestinal movement, protect intestinal mucosa and reduce bacterial translocation from intestinal lumen.

Citation： XIONG Jinwen,SHEN Wenl,CHEN Gengzhen,WEN Jun,LIU Shaojie.. Effects of Sanqizonggan on Bacterial Translocation in Rats with Acute Necrotizing Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(6): 505-507. doi: Copy