Current Status and Prospects in Treatment of Sepsis and Endotoxemia_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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蒋力生 , 陈鹏

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脓毒症; 内毒素血症; 治疗

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Citation： 蒋力生,陈鹏. Current Status and Prospects in Treatment of Sepsis and Endotoxemia. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(6): 551-553. doi: Copy

1.	O’Reilly M, Newcomb DE, Remick D. Endotoxin, sepsis, and the primrose path [Ｊ]. Shock, 1999; 12(6)∶ 411.
2.	Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine [Ｊ]. Chest， 1992; 101(6)∶ 1644.
3.	Gould IM, MacKenzie FM. The response of Enterobacteriaceae to betalactam antibiotics“round forms, filaments and the root of all evil” [Ｊ]. J Antimicrob Chemother， 1997; 40(4)∶ 495.
4.	Sprung CL, Eidelman LA, Pizov R, et al. Influence of alterations in foregoing lifesustaining treatment practices on a clinical sepsis trial. The HA1A Sepsis Study Group [Ｊ]. Crit Care Med， 1997; 25(3)∶ 383.
5.	Bone RC, Balk RA, Fein AM, et al. A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group [Ｊ]. Crit Care Med， 1995; 23(6)∶ 994.
6.	Beamer LJ, Carroll SF, Eisenberg D. Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution [Ｊ]. Science， 1997; 276(5320)∶ 1861.
7.	Axtelle T, Pribble J. IC14, a CD14 specific monoclonal antibody, is a potential treatment for patients with severe sepsis [Ｊ]. J Endotoxin Res， 2001; 7(4)∶ 310.
8.	Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome [Ｊ]. Ann Intern Med， 1993; 119(8)∶ 771.
9.	Hassouna H, Quinn C. Proteolysis of protein C in pooled normal plasma and purified protein C by activated protein C (APC) [Ｊ]. Biophys Chem， 2002; 95(2)∶ 109.
10.	Ebihara I, Nakamura T, Shimada N, et al. Effect of hemoperfusion with polymyxin Bimmobilized fiber on plasma endothelin1 and endothelin1 mRNA in monocytes from patients with sepsis [Ｊ]. Am J Kidney Dis， 1998; 32(6)∶ 953.
11.	Mitteregger R, White A, Weber C, et al. In vitro cell culture systems as the basis for an extracorporeal blood purification strategy in multiorgan failure treatment [Ｊ]. Ther Apher， 1999; 3(3)∶ 257.

1. O’Reilly M, Newcomb DE, Remick D. Endotoxin, sepsis, and the primrose path [Ｊ]. Shock, 1999; 12(6)∶ 411.
2. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine [Ｊ]. Chest， 1992; 101(6)∶ 1644.
3. Gould IM, MacKenzie FM. The response of Enterobacteriaceae to betalactam antibiotics“round forms, filaments and the root of all evil” [Ｊ]. J Antimicrob Chemother， 1997; 40(4)∶ 495.
4. Sprung CL, Eidelman LA, Pizov R, et al. Influence of alterations in foregoing lifesustaining treatment practices on a clinical sepsis trial. The HA1A Sepsis Study Group [Ｊ]. Crit Care Med， 1997; 25(3)∶ 383.
5. Bone RC, Balk RA, Fein AM, et al. A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group [Ｊ]. Crit Care Med， 1995; 23(6)∶ 994.
6. Beamer LJ, Carroll SF, Eisenberg D. Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution [Ｊ]. Science， 1997; 276(5320)∶ 1861.
7. Axtelle T, Pribble J. IC14, a CD14 specific monoclonal antibody, is a potential treatment for patients with severe sepsis [Ｊ]. J Endotoxin Res， 2001; 7(4)∶ 310.
8. Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome [Ｊ]. Ann Intern Med， 1993; 119(8)∶ 771.
9. Hassouna H, Quinn C. Proteolysis of protein C in pooled normal plasma and purified protein C by activated protein C (APC) [Ｊ]. Biophys Chem， 2002; 95(2)∶ 109.
10. Ebihara I, Nakamura T, Shimada N, et al. Effect of hemoperfusion with polymyxin Bimmobilized fiber on plasma endothelin1 and endothelin1 mRNA in monocytes from patients with sepsis [Ｊ]. Am J Kidney Dis， 1998; 32(6)∶ 953.
11. Mitteregger R, White A, Weber C, et al. In vitro cell culture systems as the basis for an extracorporeal blood purification strategy in multiorgan failure treatment [Ｊ]. Ther Apher， 1999; 3(3)∶ 257.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Current Status and Prospects in Treatment of Sepsis and Endotoxemia

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