Effects of Nitric Oxide on Growth and Metastasis of Tumor_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Jian , HE Sheng.

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Nitric oxide Tumor Biology

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

【Abstract】Objective To study the effects of nitric oxide (NO) on the growth and metastasis of tumor.
Methods The literatures of recent years were reviewed.
Results NO had double effects on the growth and metastasis of tumor. NO promoted the growth and metastasis by regulating the expression of tumor proliferation gene and inducing tumor angiogenesis. On the other hand, NO had antitumor effects by interfering with the metabolism of tumor cells, inducing the damage of DNA, forming high toxic free radical, inducing apoptosis of tumor cells and mediating the antitumor action of endothelial cells and macrophages.
Conclusion Selective blockage or induction of synthesis of NO may be a new way for tumor therapy.

Citation： ZHANG Jian,HE Sheng.. Effects of Nitric Oxide on Growth and Metastasis of Tumor. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(6): 561-563. doi: Copy

1.	Rosbe KW, Prazma J, Petrusz P, et al. Immunohistochemical characterization of nitric oxide synthase activity in squamous cell carcinoma of the head and neck [J]. Otolaryngol Head Neck Surg, 1995; 113(5)∶541.
2.	Fujimoto H, Ando Y, Yamashita T, et al. Nitric oxide synthase activity in human lung cancer [J]. Jpn J Cancer Res， 1997; 88(12)∶1190.
3.	Thomsen LL, Miles DW, Happerfield L, et al. Nitric oxide synthase activity in human breast cancer [J]. Br J Cancer， 1995; 72(1)∶41.
4.	Jenkins DC, Charles IG, Thomsen LL, et al. Roles of nitric oxide in tumor growth [J]. Proc Natl Acad Sci USA， 1995; 92(10)∶4392.
5.	Yamamoto T, Terada N, Seiyama A, et al. Increase in experimental pulmonary metastasis in mice by Larginine under inhibition of nitric oxide production by NGnitroLarginine methyl ester [J]. Int J Cancer， 1998; 75(1)∶140.
6.	Dong SM, Kim KM, Kim SY, et al. Frequent somatic mutations in serine/threonine kinase 11/PeutzJeghers syndrome gene in leftsided colon cancer [J]. Cancer Res， 1998; 58(17)∶3787.
7.	Gallo O, Masini E, Morbidelli L, et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer [J]. J Natl Cancer Inst， 1998; 90(8)∶587.
8.	Teruo I, Masahiko H, Keiko K, et al. NGnitroLarginine methyl ester inbibits bone metastasis after modified intracardiac injection of human breast cancer cells in a nude mouse model [J]. Jpn J Cancer Rev， 1997; 88(6)∶801.
9.	Lala PK, Orucevic A. Role of nitric oxide in tumor progression: lessons from experimental tumors [J]. Cancer Metastasis Rev， 1998; 17(1)∶91.
10.	Takahashi M, Fukuda K, Ohata T, et al. Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane [J]. Cancer Res. 1997; 57(7)∶1233.
11.	Tschugguel W, Knogler W, Czerwenka K, et al. Presence of endothelial calciumdependent nitric oxide synthase in breast apocrine metaplasia [J]. Br J Cancer， 1996; 74(9)∶1423.
12.	Jiang H, Stewart CA, Leu RW. Tumorderived factor synergizes with IFNgamma and LPS, IL2 or TNFalpha to promote macrophage synthesis of TNFalpha and TNF receptors for autocrine induction of nitric oxide synthase and enhanced nitric oxidemediated tumor cytotoxicity [J]. Immunobiology， 1995; 192(5)∶321.
13.	Li LM, Killoun RG, Adams J, et al. Role of nitric oxide in lysis of tumor cells by cytokineactivate endothelial cells [J]. Cancer Res, 1991; 51(5)∶531.
14.	Yasushi Y, Akiva M, Takash R, et al. p27 in human lung cancer: differential in smallcell and nonsmallcell carcinoma [J]. Cancer Res, 1998; 58(10)∶1042.
15.	Zhang J, Dawson VL, Dawson TM, et al. Nitric oxide activation of poly (ADPribose) synthetase in neurotoxicity [J]. Science, 1994; 263(8)∶687.
16.	Sagar SM, Singh G, Hodson DI, et al. Nitric oxide and anticancer therapy [J]. Cancer Treat Rev， 1995; 21(2)∶159.
17.	Ho YS, Wang YJ, Lin JK. Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells [J]. Mol Carcinog， 1996; 16(1)∶20.
18.	Harrison DJ, Howie SEM, Wyllie AH, et al. Lymphocyte death, p53 and the problem of the “undead” cell. In: Kroemer G, Martinez AC, ed. Apoptosis in immunology [M]. Berlin: SpringVerlag, 1995∶123-128.

1. Rosbe KW, Prazma J, Petrusz P, et al. Immunohistochemical characterization of nitric oxide synthase activity in squamous cell carcinoma of the head and neck [J]. Otolaryngol Head Neck Surg, 1995; 113(5)∶541.
2. Fujimoto H, Ando Y, Yamashita T, et al. Nitric oxide synthase activity in human lung cancer [J]. Jpn J Cancer Res， 1997; 88(12)∶1190.
3. Thomsen LL, Miles DW, Happerfield L, et al. Nitric oxide synthase activity in human breast cancer [J]. Br J Cancer， 1995; 72(1)∶41.
4. Jenkins DC, Charles IG, Thomsen LL, et al. Roles of nitric oxide in tumor growth [J]. Proc Natl Acad Sci USA， 1995; 92(10)∶4392.
5. Yamamoto T, Terada N, Seiyama A, et al. Increase in experimental pulmonary metastasis in mice by Larginine under inhibition of nitric oxide production by NGnitroLarginine methyl ester [J]. Int J Cancer， 1998; 75(1)∶140.
6. Dong SM, Kim KM, Kim SY, et al. Frequent somatic mutations in serine/threonine kinase 11/PeutzJeghers syndrome gene in leftsided colon cancer [J]. Cancer Res， 1998; 58(17)∶3787.
7. Gallo O, Masini E, Morbidelli L, et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer [J]. J Natl Cancer Inst， 1998; 90(8)∶587.
8. Teruo I, Masahiko H, Keiko K, et al. NGnitroLarginine methyl ester inbibits bone metastasis after modified intracardiac injection of human breast cancer cells in a nude mouse model [J]. Jpn J Cancer Rev， 1997; 88(6)∶801.
9. Lala PK, Orucevic A. Role of nitric oxide in tumor progression: lessons from experimental tumors [J]. Cancer Metastasis Rev， 1998; 17(1)∶91.
10. Takahashi M, Fukuda K, Ohata T, et al. Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane [J]. Cancer Res. 1997; 57(7)∶1233.
11. Tschugguel W, Knogler W, Czerwenka K, et al. Presence of endothelial calciumdependent nitric oxide synthase in breast apocrine metaplasia [J]. Br J Cancer， 1996; 74(9)∶1423.
12. Jiang H, Stewart CA, Leu RW. Tumorderived factor synergizes with IFNgamma and LPS, IL2 or TNFalpha to promote macrophage synthesis of TNFalpha and TNF receptors for autocrine induction of nitric oxide synthase and enhanced nitric oxidemediated tumor cytotoxicity [J]. Immunobiology， 1995; 192(5)∶321.
13. Li LM, Killoun RG, Adams J, et al. Role of nitric oxide in lysis of tumor cells by cytokineactivate endothelial cells [J]. Cancer Res, 1991; 51(5)∶531.
14. Yasushi Y, Akiva M, Takash R, et al. p27 in human lung cancer: differential in smallcell and nonsmallcell carcinoma [J]. Cancer Res, 1998; 58(10)∶1042.
15. Zhang J, Dawson VL, Dawson TM, et al. Nitric oxide activation of poly (ADPribose) synthetase in neurotoxicity [J]. Science, 1994; 263(8)∶687.
16. Sagar SM, Singh G, Hodson DI, et al. Nitric oxide and anticancer therapy [J]. Cancer Treat Rev， 1995; 21(2)∶159.
17. Ho YS, Wang YJ, Lin JK. Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells [J]. Mol Carcinog， 1996; 16(1)∶20.
18. Harrison DJ, Howie SEM, Wyllie AH, et al. Lymphocyte death, p53 and the problem of the “undead” cell. In: Kroemer G, Martinez AC, ed. Apoptosis in immunology [M]. Berlin: SpringVerlag, 1995∶123-128.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effects of Nitric Oxide on Growth and Metastasis of Tumor

Abstract Full text Figures/Tables Video References Cited by

Format

Content