ObjectiveTo explore etiopathogenesis of slow transit constipation(STC). MethodsThe model of rat with “cathartic colon” was established, and the changes of colonic electromyography of the rat was examined. ResultsThe frequency and amplitude of slow wave in vivo of rats with cathartic colon was decreased markedly. Postmeal spike potential and duration was decreased, showing that gastrocolonic reflex of rats colon was decreased.ConclusionLong term abuse of stimulant laxuatives could damage enteric nervous system and accelerate the pathological changes of STC.
Citation：
HUANG Xiankai,XU Jitai,TONG Weidong. The Change of Electromyophysiology of the Rat with Cathartic Colon. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(1): 28-29. doi:
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- 1. 童卫东，张胜本,张连阳，等. Cajal间质细胞在大鼠“泻剂结肠”结肠肌电变化中的作用 [Ｊ]. 中国普外基础与临床杂志 ， 2000； 7（5）∶288.
- 2. 李兰,陈道志,付胜峰，等.针刺对家兔胃电节律紊乱的作用研究 [M]. 见: 张经济主编. 胃肠电研究进展.兰州： 甘肃科学出版社, 1988∶236~240.
- 3. MullerLissner SA. Adverse effects of the lexatives: fact and fiction[Ｊ]. Pharmacology, 1993; 47（Suppl 1）∶138.
- 4. Sarna SK. Physiology and pathophysiology of colonic motor activity (2) [Ｊ]. Dig Dis Sci, 1991; 36(7)∶998.
- 5. 潘国宗,杨世植主编.肠道运动生理和检查方法、现代胃肠病学 [M]. 第11版. 北京： 人民卫生出版社， 1994∶1077~1080.
