The Experimental Study of the Influence of Applying Gastric Pacing to Postsurgical Gastric Dynamic_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Fuyu ¹ , HE Sheng ¹ , YU Yunhai ² , MAO Hui ¹

Department of General Surgery, West China Hospital, Sichuan University,Chengdu 610041,China;

Corresponding author：

Keywords：

Gastric pacing; Gastric dynamics; Postsurgical gastroparesis; Erythromycin

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ObjectiveTo explore the feasibility and curative effect of gastric pacing on postsurgical gastroparesis. MethodsThe indexes of gastric dynamic of applying gastric pacing to the experimental animal model of acute postsurgical gastroparesis was compared with that of injecting erythromycin (1 mg/kg).ResultsThe pressure of gastric antrum and the pressure gradient between gastric antrum and duodenum were respectively higher than basic pressure in the two experimental groups (P＜0.01); Except duodenal pressure, the indexs of gastric dynamic of pacing group were higher than that of erythromycin group (P＜0.05). The gastric emptying rate of pacing group 〔(66.37±7.21)%〕 was higher than erythromycin group 〔(49.92±9.27)%， (P＜0.01)〕. ConclusionHigherfrequency gastric pacing can improve the indexes of gastric dynamic and be applied to treat postsurgical gastroparesis, its effect may be better than erythromycin.

Citation： LI Fuyu,HE Sheng,YU Yunhai,MAO Hui. The Experimental Study of the Influence of Applying Gastric Pacing to Postsurgical Gastric Dynamic. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(1): 33-35. doi: Copy

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7.	Familoni BO，Abell TL, Nemoto D, et al.Efficacy of electrical stimulation at frequencies higher than basal rate in canine stomach [Ｊ].Dig Dis Sci, 1997； 42（5）∶892.
8.	Yokota M, Ando N, Ozawa S,et al. Enhanced motility of the vagotomized canine stomach by electrical stimulation [Ｊ]. J Gastroenterol Hepatol, 1997； 12（4）∶ 338.
9.	GEMS study groups. Report of multicenter study on electrical stimulation for the treatment of gastroparesis [Ｊ].Motili NerveGut Interact, 1997; 4（2）∶A736.
10.	McCallum RW, Chen JD, Lin Z, et al.Gastric pacing improves emptying and symptoms in patients with gastroparesis [Ｊ]. Gastroenterology, 1998； 114（3）∶456.
11.	Kelly KA. Pacing the gut [Ｊ]. Gastroenterology, 1992； 103（6）∶1967.

1. Mintchev MP, Sanmiguel CP, Otto SJ, et al. Microprocessor controlled movement of liquid gastric content using sequential neural electrical stimulation [Ｊ]. Gut, 1998; 43(5)∶607.
2. 陈思维，薛淑英，王敏华，等. 介绍一种简易实验性胃排空测定方法 [Ｊ].中医药理学通报， 1994； 5（2）∶317.
3. Kim CH, Malagelada JR. Electrical activity of the stomach: clinical implications [Ｊ]. Mayo Clin Proc， 1986; 61(3)∶205.
4. Kelly KA. Gastric motility and ulcer surgery [Ｊ]. Surg Clin North Am, 1971； 51(4 )∶927.
5. Stoddard CJ, Smallwood RH, Duthie HL. Electrical arrhythmias in human stomach [Ｊ]. Gut, 1981； 22（9）∶705.
6. Kim CH, Azpiroz F, Malagelada JR. Characteristics of spontaneous and druginduced gastric dysrhythmias in a chronic canine model [Ｊ].Gastroenterology, 1986; 90(2)∶421.
7. Familoni BO，Abell TL, Nemoto D, et al.Efficacy of electrical stimulation at frequencies higher than basal rate in canine stomach [Ｊ].Dig Dis Sci, 1997； 42（5）∶892.
8. Yokota M, Ando N, Ozawa S,et al. Enhanced motility of the vagotomized canine stomach by electrical stimulation [Ｊ]. J Gastroenterol Hepatol, 1997； 12（4）∶ 338.
9. GEMS study groups. Report of multicenter study on electrical stimulation for the treatment of gastroparesis [Ｊ].Motili NerveGut Interact, 1997; 4（2）∶A736.
10. McCallum RW, Chen JD, Lin Z, et al.Gastric pacing improves emptying and symptoms in patients with gastroparesis [Ｊ]. Gastroenterology, 1998； 114（3）∶456.
11. Kelly KA. Pacing the gut [Ｊ]. Gastroenterology, 1992； 103（6）∶1967.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Experimental Study of the Influence of Applying Gastric Pacing to Postsurgical Gastric Dynamic

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