Measurement and Significance of Serum Nitric Oxide Level in Patient with Obstructive Jaundice and Renal Dysfunction_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Hua , LI Zhiyu , ZHANG Xiaowen , LI uehua , LI Lichun , WANG Binghuang

Department of Hepatobiliary Surgery， The Second Affiliated Hospital of Kunming Medical College, Kunming 650101,China;

Corresponding author：

Keywords：

Nitric oxide; Obstructive jaundice; Renal dysfunction

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ObjectiveTo study the change and significance of the serum nitric oxide (NO) level in patient with obstructive jaundice complicated with renal dysfunction. MethodsThe level of NO, BUN, Cr in serum and the activity of NOS in 25 patients with obstructive jaundice and renal dysfunction and 26 healthy adults was studied.ResultsThe patients’ serum NO level and the activity of NOS were significantly lower than those in the control group(P＜0.01)，whereas the serum BUN and Cr levels were significantly higher than those in control group(P＜0.01). The linear correlation analysis showed that the serum NO had a negative correlation between serum BUN and Cr level (P＜0.01). ConclusionThe patients with obstructive jaundice and renal dysfunction may lead to the decrease of serum NO level. NO may have some protective effects to the renal function during obstructive jaundice.

Citation： WANG Hua,LI Zhiyu,ZHANG Xiaowen,LI uehua,LI Lichun,WANG Binghuang. Measurement and Significance of Serum Nitric Oxide Level in Patient with Obstructive Jaundice and Renal Dysfunction. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(1): 41-42. doi: Copy

1.	Fogarty BJ, Parks RW, Rowlands BJ，et al. Renal dysfunction in obstructive jaundice [J]. Br J Surg, 1995; 82（7）∶ 877.
2.	李智宇，张炳彦，王炳煌,等. 一氧化氮对急性胆道感染大鼠肾功能影响作用研究 [J]. 中国普外基础与临床杂志， 2001； 8（2）∶69.
3.	Endlich K， Muller C, Barthelmebs M， et al. Role of shear stress in nitric oxidedependent modulation of renal angiotensin Ⅱ vasoconstriction [J]. Br J Pharmacol, 1999; 127(8)∶1929.
4.	Olszanecki R, Chlopicki S.Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia [J]. J Physiol Pharmacol, 1999; 50(3)∶443.
5.	Fierro IM,NascimentoDaSilva V, Arruda MA, et al. Induction of NOS in rat blood PMN in vivo and in vitro: modulation by tyrosine kinase and involvement in bactericidal activity [J]. J Leukoc Biol, 1999; 65(4)∶508.
6.	Cowley AW,Roman RJ,Fenoy FJ,et al.Effect of renal medullary circulation on arterial pressure [J].J Hypertens Suppl, 1992; 10(7)∶S187.
7.	Goligorsky MS, Noiri E. Duality of nitric oxide in acute renal injury [J]. Semin Nephrol, 1999; 19(3)∶263.
8.	Schwartz D, Blantz RC. Nitric oxide, sepsis,and the kidney [J]. Semin Nephrol, 1999; 19(3)∶272.

1. Fogarty BJ, Parks RW, Rowlands BJ，et al. Renal dysfunction in obstructive jaundice [J]. Br J Surg, 1995; 82（7）∶ 877.
2. 李智宇，张炳彦，王炳煌,等. 一氧化氮对急性胆道感染大鼠肾功能影响作用研究 [J]. 中国普外基础与临床杂志， 2001； 8（2）∶69.
3. Endlich K， Muller C, Barthelmebs M， et al. Role of shear stress in nitric oxidedependent modulation of renal angiotensin Ⅱ vasoconstriction [J]. Br J Pharmacol, 1999; 127(8)∶1929.
4. Olszanecki R, Chlopicki S.Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia [J]. J Physiol Pharmacol, 1999; 50(3)∶443.
5. Fierro IM,NascimentoDaSilva V, Arruda MA, et al. Induction of NOS in rat blood PMN in vivo and in vitro: modulation by tyrosine kinase and involvement in bactericidal activity [J]. J Leukoc Biol, 1999; 65(4)∶508.
6. Cowley AW,Roman RJ,Fenoy FJ,et al.Effect of renal medullary circulation on arterial pressure [J].J Hypertens Suppl, 1992; 10(7)∶S187.
7. Goligorsky MS, Noiri E. Duality of nitric oxide in acute renal injury [J]. Semin Nephrol, 1999; 19(3)∶263.
8. Schwartz D, Blantz RC. Nitric oxide, sepsis,and the kidney [J]. Semin Nephrol, 1999; 19(3)∶272.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Measurement and Significance of Serum Nitric Oxide Level in Patient with Obstructive Jaundice and Renal Dysfunction

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