ObjectiveTo investigate the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in human pancreatic adenocarcinoma and their correlation with clinicobiological behavior.MethodsThe expression of COX-2 and VEGF in 51 cases of human pancreatic ductal adenocarcinoma were detected with immunohistochemistry of Envision.ResultsExpression of COX-2 and VEGF in pancreatic ductal adenocarcinoma were 74.5% and 68.6%, respectively; no expression of COX-2 and VEGF in adjacent normal tissue was detected. Both COX-2 and VEGF expression in clinical stage Ⅲ-Ⅳ were much higher than those in clinical stage Ⅰ-Ⅱ, and also higher in positive group of lymph node metastasis than in negative group as well (P lt;0.05). None of them had relation with histological grades, age, sex, tumor size and location. The expression of COX-2 was closely correlated with VEGF (r=0.411, P lt;0.01).ConclusionCOX-2 and VEGF may play a pivotal role in tumorigenesis and tumor progression in pancreatic cancer, they may provide new targets for therapy of pancreatic cancer.
Citation：
LIU Jiangwei,LI Kaizong,DOU Kefeng. Cyclooxygenase-2 Expression and Its Correlation with Vascular Endothelial Growth Factor in Pancreatic Adenocarcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 539-541. doi:
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- 1. Moran EM. Epidemiological and clinical aspects of nonsteroidal antiinflammatory drugs and cancer risks [Ｊ]. J Environ Pathol Toxicol Oncol, 2002; 21(2)∶193.
- 2. Kloppel G. Pancreatic non-endocrine tumors. In: Kloppel G. Heitz (eds). Pancreatic pathology [M]. Edinburg, Scotand: Churchill Livingstone, 1984∶79.
- 3. Hermreck AS, Thomas CY 4th, Friesen SR. Inportance of pathologic staging in the surgical managment of adenocarcinoma of the exocrine pancreas [Ｊ]. Am J Surg, 1974; 127(6)∶653.
- 4. Molina MA, SitjaArnau M, Lemoine MG, et al. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal antiinflammatory drugs [Ｊ]. Cancer Res, 1999; 59(17)∶4356.
- 5. Ikeda N, Nakajima Y, Sho M, et al. The association of K-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma [Ｊ]. Cancer, 2001; 92(3)∶488.
- 6. Ristimaki A, Sivula A, Lundin J, et al. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer [Ｊ].Cancer Res, 2002; 62(3)∶632.
- 7. Costa C, Soares R, ReisFilho JS, et al. Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer [Ｊ].J Clin Pathol, 2002; 55(6)∶429.
- 8. 李继坤， 郑淼， 李远芳， 等. p53及VEGF表达与结、直肠癌血道转移发生的关系 [Ｊ]. 中国普外基础与临床杂志， 2002； 9（2）∶112.
- 9. Niedergethmann M, Hildenbrand R, Wostbrock B, et al. High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas [Ｊ]. Pancreas, 2002; 25(2)∶122.
- 10. Seno H, Oshima M, Ishikawa TO, et al. Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta 716) mouse intestinal polyps [Ｊ]. Cancer Res, 2002; 62(2)∶506.
