Objective To investigate a new way for the treatment of severe acute pancreatitis (SAP). Methods The clinical data of 59 cases of SAP were analyzed, and they were divided into two groups: LAI group and control group. In LAI group, 30 cases were treated mainly by local arterial infusion (LAI). In control group, 29 cases were treated by intravenous infusion. Results Compared with control group, the results of LAI group were much better in abdominal pain relief, recovery of intestinal function, reducing the complications, shorter antibiotictime, decreasing the incidence of secondary systemic infection. The mortality of SAP class Ⅱ in LAI group and control group were 35.71% and 66.67% respectively. Conclusion LAI is a new way for the treatment of SAP.
Citation：
ZHANG Shu,LUO Jing,YAO Xinmin. Clinical Analysis of Local Arterial Infusion for the Treatment of Severe Acute Pancreatitis (Report of 30 Cases). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 545-547. doi:
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Takeda K, Matsuno S, Sunamura M, et al. Continuous regional arterial infusion of protease inhibitor and antibiotic in acute necrotizing pancreatitis [J]. Am J Surg， 1996； 171（4）∶394.
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- 1. Hayashi J， Kawarada Y， Isaji S, et al. Therapeutic effects of continuous intraarterial antibiotic infusion in preventing pancreatic infection in experimental acute necrotizing pancreatitis [J]. Pancreas, 1996； 13（2）∶184.
- 2. 武田和宪， 小针雅男， 砂树真琴， 他. 重症急性膵炎の新しい治疗 [J]. 最新医学， 1992； 47（10）∶2168.
- 3. 孙立波， 张德恒， 田力， 等. 区域动脉灌注5FU和抗生素降低急性坏死性胰腺炎感染及死亡率 [J]. 中国普外基础与临床杂志， 2000； 7（6）∶373.
- 4. 李鸿伟， 陆永良， 韩春蕃， 等. 区域灌注治疗急性坏死性胰腺炎的研究与应用 [J].中华实验外科杂志， 1996； 13（2）∶161.
- 5. Takeda K, Matsuno S, Sunamura M, et al. Continuous regional arterial infusion of protease inhibitor and antibiotic in acute necrotizing pancreatitis [J]. Am J Surg， 1996； 171（4）∶394.
