Clinical Application of Recombinant Human Growth Hormone on Obstructive Jaundice_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DANG Dengfeng ¹ , WANG Tong ² , WANG Chen ² , KOU Zhimin ²

Department of General Surgery, Railway Centre Hospital of Lanzhou, Lanzhou 730030, China;

Corresponding author：

Keywords：

Obstructive jaundice; Recombinant human growth hormone; Clinical application

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Objective To observe therapeutical effect of recombinant human growth hormone (rhGH) on postoperative obstructive jaundice. Methods Fourtyeight patients were divided into two groups randomly: control group with 30 patients and rhGH group with 18 patients. After operation, subcutaneous injection of rhGH was administered 8 U/d for a week. At the same time, parenteral nutrition was given to both groups until the patients could eat and drink. Biochemistry examination, endotoxin, tumor necrosis factor, sIL-2R and nutritional status were all measured at following states: before operation 1, 7 and 14 days after operation. Results Body weights of rhGH group on the fourth day after operation and that of control group on the seventh day after operation increased, but the increasing tendency of rhGH group was more prominent than the control group. For blood sugar 7 days after operation, the level of rhGH group was higher than that of control group (P＜0.05). The level of serum albumin, transferrin, prealbumin in rhGH group was higher than that of control goup （P＜0.05）. Blood serum total bile acid,total cholesterol, low density lipoprotein,glutamicoxal acetic transaminase, transglutaminase, total bilirubin, endotoxin, tumor necrosis factor and sIL-2R were all decreased compared with control group (P＜0.01). However, no significant difference was observed in renal function and electrolute between the two groups.Conclusion An improvement of nutrition status and immunologic function can be observed in obstructive jaundice patients after the postoperative administration of rhGH.

Citation： DANG Dengfeng,WANG Tong,WANG Chen,KOU Zhimin. Clinical Application of Recombinant Human Growth Hormone on Obstructive Jaundice. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 593-595. doi: Copy

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1. Ellegard L, Bosaeus I, Nordgren S, et al. Lowdose recombinant human growth hormone increases body weight and lean body mass in patients with short bowel syndrome [J]. Ann Surg, 1997； 225（1）∶88.
2. Wolf RF, Heslin MJ, Newman E，et al. Growth hormone and insulin combine to improve wholebody and skeletal muscle protein kinetics [J]. Surgery, 1992; 112(2)∶284.
3. Jeevanandam M, Holaday NJ, Petersen SR.Adjuvant recombinant human growth hormone dose not augment endogenous glucose production in total parenteral nutritionfed multiple trauma patients [J]. Metabolism, 1996; 45(4)∶450.
4. 王彤, 姜秀峰, 王琛, 等. 重组人生长激素在梗阻性黄疸的实验研究 [J]. 中国普外基础与临床杂志, 2001; 9(6)∶408.
5. 顾军, 黎介寿, 李维勤, 等. 重组生长激素对严重感染后蛋白代谢影响的实验研究 [J]. 中华外科杂志, 1997; 35(2)∶104.
6. Rubin LA, Nelson DL.The soluble interleukin2 receptor: biology, function, and clinical application [J]. Ann Intern Med, 1990; 113(8)∶619.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Application of Recombinant Human Growth Hormone on Obstructive Jaundice

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