ObjectiveTo study the expression of cyclooxygenase2 (COX2) and its clinical significance in gastric carcinoma. MethodsThe expression of COX2 in 47 cases of gastric carcinoma and 16 cases of normal gastric tissue were detected by SP immunohistochemical technique. Helicobacter pylori (H.pylori) infection was diagnosed by urease experiment and Giemsa staining.ResultsThere was no positive signal of COX2 detected in normal gastric tissue. The positive expression rate of COX2 was 63.8%(30/47) in gastric carcinoma.The expression of COX2 was correlated with TNM stage, lymph node metastasis and H.pylori infection（P＜0.01）. Positive COX2 expression rate in H.pylori infection group was 72.4%(21/29), significantly higher than that in the group without H.pylori infection.Conclusion COX2 expression is involved in the carcinogenesis and malignant progression of gastric carcinoma.The examination of COX2 may be helpful to judge biological behavior of gastric carcinoma.
Citation：
LI Yumin,XUE Qunji,ZHOU Yanming,SHI Bing,LI Xun,CAI Chen,ZHOU Wence. Expression and Significance of Cyclooxygenase-2 in Gastric Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(2): 137-139. doi:
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- 1. Zimmermann KC,Sarbia M,Weber AA,et al.Cyclooxygenase2 expression in human esophageal carcinoma [J].Cancer Res,1999; 59（1）∶198.
- 2. 胡伏莲，周殿元，贾博琦主编.幽门螺杆菌感染的基础与临床 [M].第3版.北京： 中国科学技术出版社，2000∶299～299.
- 3. 庄则豪，王立东.非甾体类抗炎药与消化道肿瘤 [J].世界华人消化杂志，2001； 9（9）∶1050.
- 4. 孙波，吴云林，张学军，等.舒林酸抑制人胃腺癌细胞增殖及诱导凋亡 [J].世界华人消化杂志，2001； 9（9）∶997.
- 5. Tsujii M,Kawano S,Tsuji S,et al.Cyclooxygenase regulates angiogenesis induced by colon cancer cells [J].Cell,1998; 93（5）∶705.
- 6. Tomozawa S,Nagawa H,Tsuno N,et al.Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX2 inhibitor,JTE522 [J].Br J Cancer,1999; 81（8）∶1274.
- 7. Sheehan KM,Sheahan K,O’Donoghue DP,et al.The relationship between cyclooxygenase2 expression and colorectal cancer [J].JAMA,1999; 282(13)∶1254.
- 8. Ristimaki A,Honkanen N,Jankala H,et al.Expression cyclooxygenase2 in human gastric carcinoma [J].Cancer Res,1997; 57(7)∶1276.
- 9. 胡伏莲，周殿元，贾博琦主编.幽门螺杆菌感染的基础与临床 [M].第3版. 北京： 中国科学技术出版社， 2000∶210~221.
- 10. Hack HM,Fennerty MB,Sampliner R,et al.Apprent reverse of intestinal metaplasia after treatment of H.pylori infection [J].Gastroenterology,1994; 106(4)∶A87.
- 11. Borody TJ,Clark IW,Andrews P,et al.Eradication of Helicobacter pylori may not reverse severe gastric dysplasia [J].Am J Gastroenterol,1995; 90(3)∶498.
- 12. McCarthy CJ,Crofford LJ,Greenson J,et al.Cyclooxygenase2 expression in gastric antral mucosa before and after eradication of Helicobacter pylori infection [J].Am J Gastroenterol,1999; 94(5)∶1218.
