ObjectiveTo observe the effect of 5Fluorouracil(5FU) on the exocrine pancreas. MethodsThe effects of 5FU were investigated in 8 patients who had undergone pancreatoduodenectomy. The pancreatic juice was temporarily diverted to the exterior via a pancreatic duct catheter.Ten days after operation,the patients were injected intravenously with 5FU 500 mg/d for three days. The samples of pancreatic juice were taken for measurement of amylase,pH, HCO3-, Na+, K+, Cl-, Ca2+ and Mg2+.ResultsThe amylase, pH, HCO3-, Na+, K+, Cl-, Ca2+ and Mg2+ did not alteredsignificantly before and after 5FU injection.Conclusion5FU has no shortterm effect on exocrine pancreas. Therefore, improvement of acute pancreatitis cannot be achieved through inhibiting pancreatic enzymes synthesis.
Citation：
JIANG Lisheng,YAO Yougui,PENG Qifang.. Effect of 5Fluorouracil on the Exocrine Pancreas. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(3): 266-267. doi:
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Johnson RM, Barone RM, Newson BL,et al. Treatment of experimental acute pancreatitis with 5Fluorouracil (5FU) [J]. Am J Surg, 1973; 125(2)∶211.
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Bielecki K, Wiedmann M, Meyer F,et al. Effect of 5Fluorouracil on secretion and synthesis of pancreatic digestive enzymes: studies in isolated pancreatic acini and perfused pancreas derived from normal rats and from rats with acute necrotizing pancreatitis [Ｊ]. Pancreas, 1994; 9(4)∶518.
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Steinberg WM, Schlesselman SE. Treatment of acute pancreatitis. Comparison of animal and human studies [Ｊ]. Gastroenterology, 1987; 93(6)∶1420.
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Niederau C, Niederau M, Luthen R,et al. Pancreatic exocrine secretion in acute experimental pancreatitis [Ｊ]. Gastroenterology, 1990; 99(4)∶1120.
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陈晓理，黄兴兰，吴浩，等. 5FU对急性胰腺炎炎症相关细胞因子的调节作用 [Ｊ].中华外科杂志，2001; 39(4)∶271.
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陈晓理，黄兴兰，吴浩，等. 常用免疫抑制剂对急性胰腺炎免疫异常的调节作用 [Ｊ].中国普外基础与临床杂志，2002; 9(6)∶384.
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- 1. Johnson RM, Barone RM, Newson BL,et al. Treatment of experimental acute pancreatitis with 5Fluorouracil (5FU) [J]. Am J Surg, 1973; 125(2)∶211.
- 2. Bielecki K, Wiedmann M, Meyer F,et al. Effect of 5Fluorouracil on secretion and synthesis of pancreatic digestive enzymes: studies in isolated pancreatic acini and perfused pancreas derived from normal rats and from rats with acute necrotizing pancreatitis [Ｊ]. Pancreas, 1994; 9(4)∶518.
- 3. Steinberg WM, Schlesselman SE. Treatment of acute pancreatitis. Comparison of animal and human studies [Ｊ]. Gastroenterology, 1987; 93(6)∶1420.
- 4. Niederau C, Niederau M, Luthen R,et al. Pancreatic exocrine secretion in acute experimental pancreatitis [Ｊ]. Gastroenterology, 1990; 99(4)∶1120.
- 5. 陈晓理，黄兴兰，吴浩，等. 5FU对急性胰腺炎炎症相关细胞因子的调节作用 [Ｊ].中华外科杂志，2001; 39(4)∶271.
- 6. 陈晓理，黄兴兰，吴浩，等. 常用免疫抑制剂对急性胰腺炎免疫异常的调节作用 [Ｊ].中国普外基础与临床杂志，2002; 9(6)∶384.
