Effect of Human Growth Hormone on Diamine Oxidase and Endotoxemia in Systemic Inflammatory Response Syndrome_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Chen , WANG Tong , LI Xusheng

Department of General Surgery, The Second Affiliated Hospital, Lanzhou Medical College, Lanzhou 730030, China;

Corresponding author：

Keywords：

Human growth hormone; Systemic inflammatory response syndrome; Diamine oxidase; EndotoxinI; ntestinal mucosa barrier

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ObjectiveTo investigate the changes of diamine oxidase(DAO) and endotoxin(ET) during the treatment of systemic inflammatory response syndrome with human growth hormone and the relationship between human growth hormone and intestinal mucosal barrier injury. MethodsOne hundred and fortysix patients with systemic inflammatory response syndrome were randomly divided into operative group and nonoperative group, which were again randomly divided into the study group and control group.Plasma concentration of DAO and ET were determined before the treatment and 1 week after the treatment.ResultsPlasma concentration of DAO and ET in study group decreased after treatment with significant difference (P＜0.05，P＜0.01).ConclusionHuman growth hormone can protect intestinal mucosa barrier.

Citation： WANG Chen,WANG Tong,LI Xusheng. Effect of Human Growth Hormone on Diamine Oxidase and Endotoxemia in Systemic Inflammatory Response Syndrome. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(3): 270-271. doi: Copy

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1. Thompson JS, Vaughan WP, Forst CF, et al. The effect of the route of nutrient delivery on gut structure and diamine oxidase levels [J]. JPEN J Parenter Enteral Nutr, 1987; 11(1)∶28.
2. Deitch EA, Sittig K, Li M, et al. Obstructive jaundice promotes bacterial translocation from the gut [Ｊ]. Am J Surg, 1990; 159(1)∶79.
3. Deitch EA. Bacterial translocation of the gut flora [Ｊ]. J Trauma, 1990; 30(12 Suppl)∶S184.
4. Kazantsev GB, Hecht DW, Rao R, et al. Plasmid labeling confirms bacterial translocation in pancreatitis [Ｊ]. Am J Surg, 1994; 167(1)∶201.
5. GomezdeSegura IA, Prieto I, Grande AG, et al. Growth hormone reduces mortality and bacterial translocation in irradiated rats [Ｊ]. Acta Oncol, 1998; 37(2)∶179.
6. 何桂珍,蒋朱明. 重组生长激素对创伤后代谢的影响 [Ｊ]. 中华医学杂志, 1995; 75(5)∶312.
7. 蒋朱明, 何桂珍, 张思源, 等. 手术后患者用生长激素及肠外营养的代谢效应 [Ｊ]. 中华外科杂志, 1995; 33(11)∶704.
8. 王彤, 姜秀峰, 王琛, 等. 重组人生长激素对梗阻性黄疸作用的实验研究 [Ｊ]. 中国普外基础与临床杂志, 2002; 9(6)∶408.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Human Growth Hormone on Diamine Oxidase and Endotoxemia in Systemic Inflammatory Response Syndrome

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