Selectin and Acute Pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041，China;

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Acute pancreatitis; Selectin

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ObjectiveTo study the function of selectin in the pathogenesis and advancement of acute pancreatitis(AP), so as to guide further investigation and clinical treatment. MethodsCorrelative articles in recent years were reviewed. ResultsSelectins act as an indicator of the activation of endothelium. Their expression changes markedly during AP and is closely related to cytokines, oxygen free radicals and complements. Conclusion Selectin is a component which is engaged in the pathology of AP, the level of selectin is useful in guiding clinical observation and treatment.

Citation： WANG Cun,ZHOU Zongguang. Selectin and Acute Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(3): 309-310. doi: Copy

1.	7KylanpaaBack ML, Takala A, Kemppainen EA, et al. Procalcitonin, soluble interleukin2 receptor, and soluble Eselectin in predicting the severity of acute pancreatitis [J]. Crit Care Med, 2001; 29(1)∶63.
2.	Petruzzelli L, Takami M, Humes HD. Structure and function of cell adhesion molecules [J]. Am J Med, 1999; 106(4)∶467.
3.	郑立新,周晓红,石应康,等. 选择素研究进展 [J]. 生物医学工程学杂志, 2000; 17(1)∶101.
4.	Fassbender K, Kaptur S, Becker P, et al. Adhesion molecules in tissue injury: kinetics of expression and shedding and association with cytokine release in humans [J]. Clin Immunol Immunopathol, 1998; 89(1)∶54.
5.	Lundberg AH, Granger DN, Russell J, et al. Quantitative measurement of P and Eselectin adhesion molecules in acute pancreatitis: correlation with distant organ injury [J]. Ann Surg, 2000; 231(2)∶213.
6.	Blann AD, Lip GY. Hypothesis: is soluble Pselectin a new marker of platelet activation? [J]. Atherosclerosis, 1997; 128(2)∶135.
7.	Powell JJ, Siriwardena AK, Fearon KC, et al. Endothelialderived selectins in the development of organ dysfunction in acute pancreatitis [J]. Crit Care Med, 2001; 29(3)∶567.
8.	秦仁义，裘法祖. 炎症介质、细胞因子在急性坏死性胰腺炎发生、发展中的作用 [J]. 中国普外基础与临床杂志， 1998； 5（6）∶361.
9.	Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration [J]. Annu Rev Physiol, 1995; 57∶827.
10.	Hughes CB, Gaber LW, Mohey elDin AB, et al. Inhibition of TNF alpha improves survival in an experimental model of acute pancreatitis [J]. Am Surg, 1996; 62(1)∶ 8.
11.	Folch E, Salas A, Panes J, et al. Role of Pselectin and ICAM1 in pancreatitisinduced lung inflammation in rats: significance of oxidative stress [J]. Ann Surg, 1999; 230(6)∶792.
12.	Telek G, Ducroc R, Scoazec JY, et al. Differential upregulation of cellular adhesion molecules at the sites of oxidative stress in experimental acute pancreatitis [J]. J Surg Res, 2001; 96(1)∶56.
13.	Hartwig W, Jimenez RE, Fernandezdel Castillo C, et al. Expression of the adhesion molecules Mac1 and Lselectin on neutrophils in acute pancreatitis is protease and complementdependent [J]. Ann Surg, 2001; 233(3)∶371.
14.	Folch E, Prats N, Hotter G, et al. Pselectin expression and Kupffer cell activation in rat acute pancreatitis [J]. Dig Dis Sci, 2000; 45(8)∶1535.
15.	Folch E, Salas A, Prats N, et al. H2O2 and PARS mediate lung Pselectin upregulation in acute pancreatitis [J]. Free Radic Biol Med, 2000; 28(8)∶1286.
16.	Norman JG, Franz MG, Fink GS, et al. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade [J]. Ann Surg, 1995; 221(6)∶625.

1. 7KylanpaaBack ML, Takala A, Kemppainen EA, et al. Procalcitonin, soluble interleukin2 receptor, and soluble Eselectin in predicting the severity of acute pancreatitis [J]. Crit Care Med, 2001; 29(1)∶63.
2. Petruzzelli L, Takami M, Humes HD. Structure and function of cell adhesion molecules [J]. Am J Med, 1999; 106(4)∶467.
3. 郑立新,周晓红,石应康,等. 选择素研究进展 [J]. 生物医学工程学杂志, 2000; 17(1)∶101.
4. Fassbender K, Kaptur S, Becker P, et al. Adhesion molecules in tissue injury: kinetics of expression and shedding and association with cytokine release in humans [J]. Clin Immunol Immunopathol, 1998; 89(1)∶54.
5. Lundberg AH, Granger DN, Russell J, et al. Quantitative measurement of P and Eselectin adhesion molecules in acute pancreatitis: correlation with distant organ injury [J]. Ann Surg, 2000; 231(2)∶213.
6. Blann AD, Lip GY. Hypothesis: is soluble Pselectin a new marker of platelet activation? [J]. Atherosclerosis, 1997; 128(2)∶135.
7. Powell JJ, Siriwardena AK, Fearon KC, et al. Endothelialderived selectins in the development of organ dysfunction in acute pancreatitis [J]. Crit Care Med, 2001; 29(3)∶567.
8. 秦仁义，裘法祖. 炎症介质、细胞因子在急性坏死性胰腺炎发生、发展中的作用 [J]. 中国普外基础与临床杂志， 1998； 5（6）∶361.
9. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration [J]. Annu Rev Physiol, 1995; 57∶827.
10. Hughes CB, Gaber LW, Mohey elDin AB, et al. Inhibition of TNF alpha improves survival in an experimental model of acute pancreatitis [J]. Am Surg, 1996; 62(1)∶ 8.
11. Folch E, Salas A, Panes J, et al. Role of Pselectin and ICAM1 in pancreatitisinduced lung inflammation in rats: significance of oxidative stress [J]. Ann Surg, 1999; 230(6)∶792.
12. Telek G, Ducroc R, Scoazec JY, et al. Differential upregulation of cellular adhesion molecules at the sites of oxidative stress in experimental acute pancreatitis [J]. J Surg Res, 2001; 96(1)∶56.
13. Hartwig W, Jimenez RE, Fernandezdel Castillo C, et al. Expression of the adhesion molecules Mac1 and Lselectin on neutrophils in acute pancreatitis is protease and complementdependent [J]. Ann Surg, 2001; 233(3)∶371.
14. Folch E, Prats N, Hotter G, et al. Pselectin expression and Kupffer cell activation in rat acute pancreatitis [J]. Dig Dis Sci, 2000; 45(8)∶1535.
15. Folch E, Salas A, Prats N, et al. H2O2 and PARS mediate lung Pselectin upregulation in acute pancreatitis [J]. Free Radic Biol Med, 2000; 28(8)∶1286.
16. Norman JG, Franz MG, Fink GS, et al. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade [J]. Ann Surg, 1995; 221(6)∶625.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Selectin and Acute Pancreatitis

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