肝移植现状与面临的挑战_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

陈实

Corresponding author：

Keywords：

肝移植; 供肝来源; 病毒性肝炎; 肝、胆恶性肿瘤; HLA配型; 移植肝慢性功能减退或丧失

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

进入21世纪以来，肝移植已经成为治疗终末期肝脏疾病、急性暴发性肝功能衰竭的一种最有效的选择。据美国UNOS报道，在过去10年中，全世界已实施26 040例肝移植；在先进的移植中心，肝移植受者的1年和3年存活率分别达到90%和80%，5年存活率达65%～75%，儿童肝移植和亲属活体肝移植存活率更高，除了存活时间延长外，生活质量得到明显改善，包括恢复工作和生育能力。国内近年来肝移植也得到快速发展，年移植数在千例左右，开展的单位不断增加，存活率得到提高，在先进的单位，开展的项目和水平逐渐接近国际水平。

Citation： 陈实. 肝移植现状与面临的挑战. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(4): 315-317. doi: Copy

1.	Chen CL, Fan ST, Lee SG, et al. Livingdonor liver transplantation: 12 years of experience in Asia [J]. Transplantation， 2003; 75(3 Suppl)∶S6.
2.	Lo CM. Complications and longterm outcome of living liver donors: a survey of 1,508 cases in five Asian centers [J]. Transplantation， 2003; 75(3 Suppl)∶ S12.
3.	Surman OS. The ethics of partialliver donation [J]. N Engl J Med, 2002; 346(14)∶1038.
4.	Cuende N， Grande L， Sanjuan F，et al. Liver transplant with organs from elderly donors: Spanish experience with more than 300 liver donors over 70 years of age [J]. Transplantation, 2002; 73(8)∶1360.
5.	Inomata Y, Nakamura T,Uemoto S, et al.Domino splitliver transplantation from a living donor: case reports of in situ and ex situ splitting [J]. Liver Transpl, 2001; 7(2)∶150.
6.	Tanabe M, Shimazu M, Wakabayashi G，et al. Intraportal infusion therapy as a novel approach to adult ABOincompatible liver transplantation [J]. Transplantation, 2002; 73(12)∶1959.
7.	Narayanan Menon KV, Poterucha JJ, ElAmin OM, et al.Treatment of posttransplantation recurrence of hepatitis C with interferon and ribavirin:lessons on tolerability and efficacy [J]. Liver Transpl, 2002; 8(7)∶623.
8.	de Villa VH, Chen YS, Chen CL. Hepatitis B core antibodypositive grafts: recipient’s risk [J]. Transplantation, 2003; 75(3 Suppl)∶S49.
9.	Hwang S， Moon DB， Lee SG，et al. Safety of antihepatitis B core antibodypositive donors for livingdonor liver transplantation [J]. Transplantation, 2003; 75(3 Suppl)∶S45.
10.	Lo CM, Fan ST, Liu CL, et al. Prophylaxis and treatment of recurrent hepatitis B after liver transplantation [J]. Transplantation, 2003; 75(3 Suppl)∶S41.
11.	Vivarelli M, Bellusci R, Cucchetti A, et al. Low recurrence rate of hepatocellular carcinoma after liver transplantation: better patient selection or lower immunosuppression? [J]. Transplantation, 2002; 74 (12)∶1746.
12.	Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for treatment of small hepatocellular carcinomas in patients with cirrhosis [J]. N Engl J Med, 1996; 334(11)∶693.
13.	De Vreede I, Steers JL, Burch PA, et al. Prolonged diseasefree survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma [J]. Liver Transpl, 2000; 6(3)∶309.
14.	Opelz G, Margreiter R, Dohler B. Prolongation of longterm kidney graft survival by a simultaneous liver transplant: the liver does it, and the heart does it too [J]. Transplantation, 2002; 74(10)∶1390.
15.	Neumann UP， Guckelberger O， Langrehr JM, et al.Impact of human leukocyte antigen matching in liver transplantation [J]. Transplantation， 2003; 75(1)∶132.
16.	Bilir BM, Guinette D, Karrer F, et al. Hepatocyte transplantation in acute liver failure [J]. Liver Transpl, 2000; 6(1)∶32.
17.	Kren BT， Chowdhury NR， Chowdhury JR，et al. Gene therapy as an alternative to liver transplantation [J]. Liver Transpl， 2002; 8(12)∶1089.
18.	Uekei T, Kaneda Y, Tsutsui H, et al. Hepatocyte growth factor gene therapy of liver cirrhosis in rat [J]. Nat Med, 1999； 5(2)∶226.
19.	Starzl TE, Fung J, Tzakis A, et al. Baboontohuman liver transplantation [J]. Lancet, 1993; 341(8837)∶65.
20.	Horslen SP, Hammel JM, Fristoe LW, et al. Extracorporeal liver perfusion using human and pig livers for acute liver failure [J]. Transplantation, 2000； 70(10)∶1472.
21.	Dekel B, Burakova T, Arditti FD, et al. Human and porcine early kidney precursors as a new source for transplantation [J]. Nat Med, 2003; 9(1)∶53.
22.	Kaihara S, Borenstein J, Koka R, et al. Silicon micromachining to tissue engineer branched vascular channels for liver fabrication [J]. Tissue Eng, 2000; 6(2)∶105.

1. Chen CL, Fan ST, Lee SG, et al. Livingdonor liver transplantation: 12 years of experience in Asia [J]. Transplantation， 2003; 75(3 Suppl)∶S6.
2. Lo CM. Complications and longterm outcome of living liver donors: a survey of 1,508 cases in five Asian centers [J]. Transplantation， 2003; 75(3 Suppl)∶ S12.
3. Surman OS. The ethics of partialliver donation [J]. N Engl J Med, 2002; 346(14)∶1038.
4. Cuende N， Grande L， Sanjuan F，et al. Liver transplant with organs from elderly donors: Spanish experience with more than 300 liver donors over 70 years of age [J]. Transplantation, 2002; 73(8)∶1360.
5. Inomata Y, Nakamura T,Uemoto S, et al.Domino splitliver transplantation from a living donor: case reports of in situ and ex situ splitting [J]. Liver Transpl, 2001; 7(2)∶150.
6. Tanabe M, Shimazu M, Wakabayashi G，et al. Intraportal infusion therapy as a novel approach to adult ABOincompatible liver transplantation [J]. Transplantation, 2002; 73(12)∶1959.
7. Narayanan Menon KV, Poterucha JJ, ElAmin OM, et al.Treatment of posttransplantation recurrence of hepatitis C with interferon and ribavirin:lessons on tolerability and efficacy [J]. Liver Transpl, 2002; 8(7)∶623.
8. de Villa VH, Chen YS, Chen CL. Hepatitis B core antibodypositive grafts: recipient’s risk [J]. Transplantation, 2003; 75(3 Suppl)∶S49.
9. Hwang S， Moon DB， Lee SG，et al. Safety of antihepatitis B core antibodypositive donors for livingdonor liver transplantation [J]. Transplantation, 2003; 75(3 Suppl)∶S45.
10. Lo CM, Fan ST, Liu CL, et al. Prophylaxis and treatment of recurrent hepatitis B after liver transplantation [J]. Transplantation, 2003; 75(3 Suppl)∶S41.
11. Vivarelli M, Bellusci R, Cucchetti A, et al. Low recurrence rate of hepatocellular carcinoma after liver transplantation: better patient selection or lower immunosuppression? [J]. Transplantation, 2002; 74 (12)∶1746.
12. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for treatment of small hepatocellular carcinomas in patients with cirrhosis [J]. N Engl J Med, 1996; 334(11)∶693.
13. De Vreede I, Steers JL, Burch PA, et al. Prolonged diseasefree survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma [J]. Liver Transpl, 2000; 6(3)∶309.
14. Opelz G, Margreiter R, Dohler B. Prolongation of longterm kidney graft survival by a simultaneous liver transplant: the liver does it, and the heart does it too [J]. Transplantation, 2002; 74(10)∶1390.
15. Neumann UP， Guckelberger O， Langrehr JM, et al.Impact of human leukocyte antigen matching in liver transplantation [J]. Transplantation， 2003; 75(1)∶132.
16. Bilir BM, Guinette D, Karrer F, et al. Hepatocyte transplantation in acute liver failure [J]. Liver Transpl, 2000; 6(1)∶32.
17. Kren BT， Chowdhury NR， Chowdhury JR，et al. Gene therapy as an alternative to liver transplantation [J]. Liver Transpl， 2002; 8(12)∶1089.
18. Uekei T, Kaneda Y, Tsutsui H, et al. Hepatocyte growth factor gene therapy of liver cirrhosis in rat [J]. Nat Med, 1999； 5(2)∶226.
19. Starzl TE, Fung J, Tzakis A, et al. Baboontohuman liver transplantation [J]. Lancet, 1993; 341(8837)∶65.
20. Horslen SP, Hammel JM, Fristoe LW, et al. Extracorporeal liver perfusion using human and pig livers for acute liver failure [J]. Transplantation, 2000； 70(10)∶1472.
21. Dekel B, Burakova T, Arditti FD, et al. Human and porcine early kidney precursors as a new source for transplantation [J]. Nat Med, 2003; 9(1)∶53.
22. Kaihara S, Borenstein J, Koka R, et al. Silicon micromachining to tissue engineer branched vascular channels for liver fabrication [J]. Tissue Eng, 2000; 6(2)∶105.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

肝移植现状与面临的挑战

Abstract Full text Figures/Tables Video References Cited by

Format

Content