The Expression and Significance of Multidrug Resistant Gene mdr1 in Hepatocellular Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

QUAN Yi , YAN Lnan

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041， China;

Corresponding author：

Keywords：

Multidrug resistance gene mdr1; Hepatocellular carcinoma

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ObjectiveTo explore the relationship between mdr1 gene expression of hepatocellular carcinoma (HCC) and pathological characteristics,chemotherapy and prognosis. MethodsThe mdr1 gene expression of HCC in 56 patients with the methods of immunohistochemistry was studied. The results were analysed with the pathological data by statistic methods. ResultsThe positive expression of mdr1 gene in cancer tissues and pericancerous tissues of HCC were 30/56(53.6%) and 19/56 (33.9%) respectively. The difference was statistically significant (χ2=4.39,P＜0.05). The positive expression of mdr1 gene in cancer tissues of untreated patients and in recurrent patients were 22/48(45.8%) and 8/8(100%) respectively.The expression of mdr1 gene was not associated with tumor size, number, tumor thrombus, differentiation, HBsAg and liver cirrhosis. The patients with positive mdr1 expression had a shorter survival time than that of negative ones. But the difference was not statistically significant. Conclusion The positive expression of mdr1 in HCC is 53.6%. It is not associated with tumor size, number, tumor thrombus, tumor differentiation, HBsAg and liver cirrhosis. There are innate multidrug resistance in HCC.

Citation： QUAN Yi,YAN Lnan. The Expression and Significance of Multidrug Resistant Gene mdr1 in Hepatocellular Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(4): 370-372. doi: Copy

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1. Roninson IB.The role of mdr1 (Pglycoprotein) gene in multidrug resistance in vitro and in vivo [J].Biochem Pharmacol, 1992； 43(1)∶95.
2. Horio M, Gottesman MM， Pastan I. ATPdependent transport of vinblastine in vesicles from human multidrugresistant cells [J]. Proc Natl Acad Sci USA, 1988； 85(10)∶3580.
3. 罗华友,杨家印,林琦远，等.反义硫代磷酸寡核苷酸逆转肝癌细胞多药耐药的实验研究 [J].中国普外基础与临床杂志, 2001； 8（4）∶220.
4. Itsubo M,Ishikawa T,Toda G,et al. Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product Pglycoprotein in primary liver carcinoma [J]. Cancer, 1994； 73(2)∶298.
5. Chenivesse X,Franco D, Brechot C. mdr1 (multidrug resistance) gene expression in human primary liver cancer and cirrhosis [J].J Hepatol, 1993； 18(2)∶168.
6. 韩军,许良中,朱雄增.多药耐药基因产物P糖蛋白在正常人体组织中分布和细胞定位 [J].上海医科大学学报, 1997； 24(2)∶94.
7. Weinstein RS, Jakate SM, Dominguez JM, et al. Relationship of the expression of the multidrug resistance gene product (Pglycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis [J]. Cancer Res,1991； 51(10)∶2720.
8. Nussler V,PelkaFleischer R,Zwierzina H, et al. Pglycoprotein expression in patients with acute leukemiaclinical relevance [J]. Leukemia,1996； 10（Suppl 3）∶S23.
9. Verrelle P, Meissonnier F, Fonck Y, et al. Clinical relevance of immunohistochemical detection of multidrug resistance Pglycoprotein in breast carcinoma [J]. J Natl Cancer Inst, 1991； 83(2)∶111.
10. Sinicrope FA,Hart J,Brasitus TA,et al. Relationship of Pglycoprotein and carcinoembryonic antigen expression in human colon carcinoma to local invasion DNA ploidy, and disease relapse [J].Cancer,1994； 74(11)∶2908.
11. Duensing S,Dallmann I,Grosse J,et al. Immunocytochemical detection of Pglycoprotein initial expression correlates with survival in renal cell carcinoma patients [J].Oncology,1994； 51(4)∶309.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Expression and Significance of Multidrug Resistant Gene mdr1 in Hepatocellular Carcinoma

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