bjective To study the change of mucins of expression in lithic cholecystitis and cholecystic adenomatiod polyps. MethodsMUC1 and MUC3 were detected in the mucosa of human normal gallbladders (20 cases, control group), of calcareous cholecystitis (38 cases, calcareous group) and of adenomatoid polyps (18 cases, polyp group) with immunohistochemical stains and Western blotting methods. ResultsThe positive rate and optical density values of MUC1 were increased significantly in calcareous and polyp group vs control group (P＜0.01), otherwise, MUC3 was decreased markedly (P＜0.01). Conclusion The expressions of MUC1, MUC3 were not synchronization in different lesions of cholecyst.
Citation：
CAO Hong,CHEN Dongfeng,ZHENG Wei. Value of MUC1 and MUC3 in the Calcareous Cholocystitis and Cholecystic Adenomatoid Polyps. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(4): 379-382. doi:
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- 1. 蔡文琴, 王泊云主编. 实用免疫细胞化学与核酸分子杂交技术[M]. 成都: 四川科学技术出版社, 1994∶496～497.
- 2. 金冬雁, 黎孟枫译. 分子克隆实验指南[M]. 北京: 科学出版社，1995∶888~905.
- 3. Voynow JA, Rose MC. Quantitation of mucin mRNA in respiratory and intestinal epithelial cells [J]. Am J Respir Cell Mol Biol, 1994; 11(6)∶742.
- 4. Madrid JF, Hernandez F, Ballesta J. Characterization of glycoproteins in the epithelial cells of human and other mammalian gallbladder [J]. Microsc Res Tech, 1997； 38(6)∶616.
- 5. BiemerHuttmann AE, Walsh MD, McGuckin MA, et al. Immunohistochemical staining patterns of MUC1, MUC2, MUC4 and MUC5 AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum [J]. J Histochem Cytochem, 1999; 47(8)∶1039.
- 6. Yonezawa S, Sato E. Expression of mucin antigens in human cancers and its relationship with malignancy potential [J]. Pathol Int, 1997; 47(12)∶813.
- 7. Yamato T, Kurumaya H, Ohama K, et al. Frequent expression of mucin core protein MUC1 in nonneoplastic gallbladder mucosa from patients with pancreaticobiliary maljunction [J]. Liver, 1999; 19(4)∶281.
- 8. HO SB, Shekels LL, Toribara NW, et al. Altered mucin core peptide expression in acute and chronic chelecystitis [J]. Dig Dis Sci, 2000; 45(6)∶1061.
- 9. Cao Y, Blohm D, Ghadimi BM, et al. Mucins (MUC1 and MUC3) of gastrointestinal and breast epithelia reveal different and heterogeneous tumorassociated aberrations in glycosylation [J]. J Histochem Cytochem, 1997; 45(11)∶1547.
