The Relationship Between the Apoptosis Hepatocyte and Its Genic Mediation and the Ischemia of Portal Vein_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

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Keywords：

Ischemia; Portal vein; Hepatocyte apoptosis; Gene

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ObjectiveTo introduce the relationship between the apoptosis hepatocyte and its genic mediation and the ischemia of portal vein. MethodsThe combination of related literatures and our research findings were made.ResultsPortal vein ischemia may induced hepatocyte apoptosis, p53 and bcl2 gene alternatively adjust hepatocyte apoptosis. Expression of p53 gene is enhanced in hepatic tissue when hepatocyte apoptosis is not obvious, but after 24-72 h of portal vein ischemia, when hepatocyte apoptosis is obvious, enhanced expression of p53 gene or reduced expression of bcl2 gene occur. There exists close relationship between portal vein ischemia and hepatocyte apoptosis. Conclusion Apoptosis hepatocyte is involved in organic atrophy after ischemia of portal vein, and p53 and bcl2 gene alternatively adjust hepatocyte apoptosis. At present, the mechanism of apoptosis of hepatocyte induced by ischemia of portal vein is not clear, which needs further study.

Citation： LI Jingdong,LI Bo. The Relationship Between the Apoptosis Hepatocyte and Its Genic Mediation and the Ischemia of Portal Vein. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(4): 419-421. doi: Copy

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7.	Feldmann G, Lamboley C, Moreau A, et al. Fasmediated apoptosis of hepatic cells [J]. Biomed Pharmacother, 1998; 52(9)∶378.
8.	Van Molle W, Brouckaert P, Libert C. Caspase1 is not involved in experimental hepatitis in mouse [J]. FEBS Lett, 1999; 445(1)∶115.
9.	Afford SC, Randhawe S, Eliopoulous AG, et al. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fasmediated hepatocyte death during allograft rejection [J]. J Exp Med,1999; 189(2)∶441.
10.	Shimamasu K, Wanless IR. Role of ischemia in causing apoptosis, atrophy and nodular hyperplasia in human liver [J]. Hepatology， 1997; 26(2)∶343.
11.	Gobe GC, Axelsen RA , Searle JW. Cellular events in experimental unilateral ischemic renal atrophy and in regeneration after contralateral nephrectomy [J]. Lab Invest, 1990; 63(6)∶770.
12.	Rokicki M, Rokicki W. Liver regeneration in rats after complete and partial occlusion of the portal blood influx [J]. Res Exp Med (Berl), 1993; 193(5)∶305.
13.	Edgcomb LP, Eckhauser FE, PorterFink VL, et al. Effects of portacaval shunt and portacaval transposition on hepatocelluar and hepatic reticuloendothelial cell activity in the dog [J]. J Surg Res, 1984; 36(5)∶446.
14.	Rocheleau B, Ethier C, Houle R, et al. Hepatic artery buffer response following left portal vein ligation: its role in liver tissue homeostasis [J]. Am J Physiol， 1999; 277(5 Pt 1)∶G1000.
15.	Ikeda K, Kinoshita H, Hirohashi K, et al. The ultrastructure, kinetics and intralobular distribution of apoptotic hepatocytes after portal branch ligation with special reference to their relationship to necrotic hepatocytes [J]. Arch Histol Cytol， 1995; 58(2)∶171.
16.	李敬东，覃杨，李波，等.p53和bcl2在大鼠门静脉缺血后肝细胞凋亡中表达的初步研究.中国生物化学与分子生物学会，第八届会员代表大会暨全国学术会议论文摘要 [C]. 上海：中国生物化学与分子生物学会， 2001∶237.
17.	Arber N, Zajicek G, Ariel I. The streaming liver II: hepatocyte life history [J]. Liver, 1988; 8(2)∶80.

1. Alison MR, Sarraf CE. Liver cell death: mechanism and patterns [J]. Gut, 1994; 35(5)∶577.
2. Peitsch MC, Muller C, Tschopp J. DNA fragmentation during apoptosis is caused by frequent singlestrand cuts [J]. Nucleic Acids Res, 1999; 21(18)∶4206.
3. Ahn SG, Jeong SY, Rhim H, et al. The role of cmyc and heat shock protein 70 in human hepatocarcinoma Hep3B cells during apoptosis induced by prostaglandin A2/Deltal2 prostaglandin J2 [J]. Biochim Biophys Acta, 1998; 1448（1）∶115.
4. 黄洁夫主编. 肝脏胆道肿瘤外科学 [M]. 第1版.北京：人民卫生出版社出版， 1999∶58～59.
5. 王志洁，范维柯. p53基因与肿瘤细胞凋亡 [J]. 国外医学临床生物化学与检验学分册, 2000; 21（2）∶93.
6. 邱莲女，周永列. Bcl2与肿瘤关系的研究进展 [J]. 国外医学临床生物化学与检验学分册， 2000; 21（4）∶196.
7. Feldmann G, Lamboley C, Moreau A, et al. Fasmediated apoptosis of hepatic cells [J]. Biomed Pharmacother, 1998; 52(9)∶378.
8. Van Molle W, Brouckaert P, Libert C. Caspase1 is not involved in experimental hepatitis in mouse [J]. FEBS Lett, 1999; 445(1)∶115.
9. Afford SC, Randhawe S, Eliopoulous AG, et al. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fasmediated hepatocyte death during allograft rejection [J]. J Exp Med,1999; 189(2)∶441.
10. Shimamasu K, Wanless IR. Role of ischemia in causing apoptosis, atrophy and nodular hyperplasia in human liver [J]. Hepatology， 1997; 26(2)∶343.
11. Gobe GC, Axelsen RA , Searle JW. Cellular events in experimental unilateral ischemic renal atrophy and in regeneration after contralateral nephrectomy [J]. Lab Invest, 1990; 63(6)∶770.
12. Rokicki M, Rokicki W. Liver regeneration in rats after complete and partial occlusion of the portal blood influx [J]. Res Exp Med (Berl), 1993; 193(5)∶305.
13. Edgcomb LP, Eckhauser FE, PorterFink VL, et al. Effects of portacaval shunt and portacaval transposition on hepatocelluar and hepatic reticuloendothelial cell activity in the dog [J]. J Surg Res, 1984; 36(5)∶446.
14. Rocheleau B, Ethier C, Houle R, et al. Hepatic artery buffer response following left portal vein ligation: its role in liver tissue homeostasis [J]. Am J Physiol， 1999; 277(5 Pt 1)∶G1000.
15. Ikeda K, Kinoshita H, Hirohashi K, et al. The ultrastructure, kinetics and intralobular distribution of apoptotic hepatocytes after portal branch ligation with special reference to their relationship to necrotic hepatocytes [J]. Arch Histol Cytol， 1995; 58(2)∶171.
16. 李敬东，覃杨，李波，等.p53和bcl2在大鼠门静脉缺血后肝细胞凋亡中表达的初步研究.中国生物化学与分子生物学会，第八届会员代表大会暨全国学术会议论文摘要 [C]. 上海：中国生物化学与分子生物学会， 2001∶237.
17. Arber N, Zajicek G, Ariel I. The streaming liver II: hepatocyte life history [J]. Liver, 1988; 8(2)∶80.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Relationship Between the Apoptosis Hepatocyte and Its Genic Mediation and the Ischemia of Portal Vein

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