The Expression of Sialyl LewisX and CD44v6 and Their Relationship with Biological Behaviors in Cholangiocarcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

GU Huaping ¹

Department of Pathology, The 251st Hospital of PLA, Zhangjiakou 075000, China;

Corresponding author：

Keywords：

CholangiocarcinomaSialyl LewisX antigenCD44v6Biological behavior

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ObjectiveTo study the relationship between the expression of sialyl Lewisx (SLeX) antigen and CD44v6 products and biological behaviors in cholangiocarcinomas. MethodsThe expression of SLeX and CD44v6 in 43 cases of cholangiocarcinoma tissue was respectively investigated by catalyzed signal amplification immunohistochemical technique.The relationship between expression of SLeX and CD44v6 and the clinicopathological factors of cholangiocarcinoma was analyzed.ResultsThe positive expression rate of SLeX and CD44v6 in cholangiocarcinoma was 67.4% and 62.8% respectively,which was significantly higher than that in control group (20.0%,P＜0.05).The high level expression of SLeX and CD44v6 were correlated with the TNM phase, differentiation degree,metastasis to lymph nodes and viscera in cholangiocarcinoma (P＜0.05). Moreover,there was a positive correlation between the SLeX and CD44v6 expression in cholangiocarcinoma (r=0.49,P＜0.001).Conclusion Expression of SLeX and CD44v6 could be helpful in predicting the biological behavior and prognosis of cholangiocarcinoma.

Citation： GU Huaping,SHANG Peizhong,LIU Yanru. The Expression of Sialyl LewisX and CD44v6 and Their Relationship with Biological Behaviors in Cholangiocarcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(5): 442-444. doi: Copy

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1. Brooks SA, Leathem AJ. Expression of the CD15 antigen (Lewis X) in breast cancer [J]. Histochem J， 1995； 27(9)∶689.
2. Nakagoe T, Fukushima K, Hirota M, et al. Immunohistochemical expression of sialyl Lex antigen in relation to survival of patients with colorectal carcinoma [J]. Cancer， 1993; 72(8)∶2323.
3. Konety BR,Ballou B,Jaffe R,et al.Expression of SSEA1(Lewis x) on transitional cell carcinoma of the bladder [J].Urol Int, 1997; 58(2)∶69.
4. 谷化平,尚培中,纪小龙,等.甲状腺肿瘤中CD15抗原的表达及临床意义 [J]. 中华内分泌代谢杂志, 2000; 16(1)∶31.
5. 谷化平,倪灿荣,詹溶洲,等.肝细胞癌中CD15和nm23H1的mRNA表达及其意义 [J]. 中国普外基础与临床杂志, 2001; 8(4)∶242.
6. 李子奈,邱建龙,吴春林,等.粘附分子CD44v6和Ecadherin的表达与甲状腺乳头状癌侵袭转移的关系 [J]. 中国普外基础与临床杂志, 2001; 8(5)∶317.
7. 金卫中,杨东慧,赵景轩,等.nm23、CD44H和CD44v6蛋白在胃癌的表达及意义 [J]. 中国普外基础与临床杂志, 2000; 7(3)∶141.
8. Christopher J, Amil K. CD44 isoform expression in primary and metastatic pancreatic adenocarcinoma [J]. Cancer Res, 1995; 55(4)∶1831.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Expression of Sialyl LewisX and CD44v6 and Their Relationship with Biological Behaviors in Cholangiocarcinoma

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