USE OF PROPHYLACTIC ANTIBIOTICS IN SURGERY_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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唐伟松

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Keywords：

抗生素; 预防; 手术; 手术野感染

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手术野感染（surgical site infection, SSI）是外科手术的并发症之一。为预防和减少SSI，采用了不少措施：提高空气的洁净度，良好的患者皮肤准备和肠道准备，治疗已存在的感染灶，提高术中防护，减少术中污染。预防性抗生素的使用是重要措施之一。多年实践证明，预防性抗生素使用，可以减低SSI发生率。近来预防性抗生素使用已近乎成为常规了，抗生素用量迅速增长。但如何使用预防性抗生素在临床上缺乏统一的认识与规范。

Citation： 唐伟松. USE OF PROPHYLACTIC ANTIBIOTICS IN SURGERY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(1): 6-7. doi: Copy

1.	Page CP, Bohnen JMA, Fletcher JR, et al. Antimicrobial prophylaxis for surgical wounds. Guidelines for clinical care [Ｊ]. Arch Surg, 1993; 128(1)∶79.
2.	Kaiser AB. Antimicrobial prophylaxis in surgery [Ｊ]. N Engl J Med, 1986; 315(18)∶1129.
3.	Cainzos MA. Antibiotic prophylaxis [Ｊ].New Horizons, 1998; 6(2 Suppl)∶S11.
4.	Alexander JW, Altemeier WA. Penicillin prophylaxis of experimental staphylococal woud infections [Ｊ].Surg Gynecol Obstet, 1965; 120(2)∶243.
5.	Velasco E,Thuler LCS, Martins CAS, et al.Risk factors for infection complications after abdominal surgery for malignant disease [Ｊ].Am J Infect Cont, 1996; 24(1)∶1.
6.	Kreisel D， Savel TG, Silver AL, et al. Surgical antibiotic prophylaxis and clostridium difficile toxin positivity [Ｊ]. Arch Surg, 1995; 130(9)∶989.
7.	Lewis RT, Weigand FM, Mamazza J, et al. Should antibiotic prophylaxis be used routinely in clean surgical procedure: a tentative yes [Ｊ]. Surgery, 1995; 118(4)∶742.
8.	Taylor EW, Byrne DJ, Leaper DJ,et al. Antibiotic prophylaxis and open groin hernia repair [Ｊ]. World J Surg, 1997; 21(8)∶811.
9.	唐伟松，李小毅，杨志英,等. 预防性抗生素在普外科手术中的应用 [Ｊ].中华普通外科杂志，2001； 16（7）∶445.
10.	Plett R, Zaleznik DF， Hopkins CC，et al.Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery [Ｊ]. N Engl J Med, 1990; 322(3)∶153.
11.	Illig KA, Schmidt E, Gavanaugh J, et al.Are prophylactic antibiotics required for elective laparoscopic cholecystectomy [Ｊ]? J Am Coll Surg, 1997; 184(4)∶353.
12.	Song F, Glenny AM. Antimicrobial propylaxis in colorectal surgery: a systematic review of randomized controlled trials [Ｊ]. Br J Surg, 1998; 85(9)∶1232.
13.	Classen DC,Evans RS, Pestonik SL, et al. The timing of prophyactic administration of antibiotics and the risk of surgicalwound infection [Ｊ].N Engl J Med, 1992; 326(5)∶281.
14.	Tang TM, Tam PK, Saing H. Antibiotic prophylaxis in acute nonperforated appendicitis in children: single dose of metronidazole and gentamycin [Ｊ]. J R Coll Surg Edinb, 1992; 37(2)∶110.
15.	Swoboda SM, Merz C,Kostuik J, et al. Does intraoperative blood loss affect antibiotic serum and tissue concentrations [Ｊ]? Arch Surg, 1996; 131(11)∶1165.
16.	杨志英，唐伟松.腹部手术应用短程抗生素预防手术区感染的疗效分析 [Ｊ].中华外科杂志，2001； 39（10）∶770.
17.	刘玉村，高付生，万远廉,等. 结肠手术预防应用头孢三嗪的临床研究和实验研究 [Ｊ]. 中华外科杂志， 1998；增刊∶25.

1. Page CP, Bohnen JMA, Fletcher JR, et al. Antimicrobial prophylaxis for surgical wounds. Guidelines for clinical care [Ｊ]. Arch Surg, 1993; 128(1)∶79.
2. Kaiser AB. Antimicrobial prophylaxis in surgery [Ｊ]. N Engl J Med, 1986; 315(18)∶1129.
3. Cainzos MA. Antibiotic prophylaxis [Ｊ].New Horizons, 1998; 6(2 Suppl)∶S11.
4. Alexander JW, Altemeier WA. Penicillin prophylaxis of experimental staphylococal woud infections [Ｊ].Surg Gynecol Obstet, 1965; 120(2)∶243.
5. Velasco E,Thuler LCS, Martins CAS, et al.Risk factors for infection complications after abdominal surgery for malignant disease [Ｊ].Am J Infect Cont, 1996; 24(1)∶1.
6. Kreisel D， Savel TG, Silver AL, et al. Surgical antibiotic prophylaxis and clostridium difficile toxin positivity [Ｊ]. Arch Surg, 1995; 130(9)∶989.
7. Lewis RT, Weigand FM, Mamazza J, et al. Should antibiotic prophylaxis be used routinely in clean surgical procedure: a tentative yes [Ｊ]. Surgery, 1995; 118(4)∶742.
8. Taylor EW, Byrne DJ, Leaper DJ,et al. Antibiotic prophylaxis and open groin hernia repair [Ｊ]. World J Surg, 1997; 21(8)∶811.
9. 唐伟松，李小毅，杨志英,等. 预防性抗生素在普外科手术中的应用 [Ｊ].中华普通外科杂志，2001； 16（7）∶445.
10. Plett R, Zaleznik DF， Hopkins CC，et al.Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery [Ｊ]. N Engl J Med, 1990; 322(3)∶153.
11. Illig KA, Schmidt E, Gavanaugh J, et al.Are prophylactic antibiotics required for elective laparoscopic cholecystectomy [Ｊ]? J Am Coll Surg, 1997; 184(4)∶353.
12. Song F, Glenny AM. Antimicrobial propylaxis in colorectal surgery: a systematic review of randomized controlled trials [Ｊ]. Br J Surg, 1998; 85(9)∶1232.
13. Classen DC,Evans RS, Pestonik SL, et al. The timing of prophyactic administration of antibiotics and the risk of surgicalwound infection [Ｊ].N Engl J Med, 1992; 326(5)∶281.
14. Tang TM, Tam PK, Saing H. Antibiotic prophylaxis in acute nonperforated appendicitis in children: single dose of metronidazole and gentamycin [Ｊ]. J R Coll Surg Edinb, 1992; 37(2)∶110.
15. Swoboda SM, Merz C,Kostuik J, et al. Does intraoperative blood loss affect antibiotic serum and tissue concentrations [Ｊ]? Arch Surg, 1996; 131(11)∶1165.
16. 杨志英，唐伟松.腹部手术应用短程抗生素预防手术区感染的疗效分析 [Ｊ].中华外科杂志，2001； 39（10）∶770.
17. 刘玉村，高付生，万远廉,等. 结肠手术预防应用头孢三嗪的临床研究和实验研究 [Ｊ]. 中华外科杂志， 1998；增刊∶25.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

USE OF PROPHYLACTIC ANTIBIOTICS IN SURGERY

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