The Expression of cerb B2 and Cathepsin D in Gastric Carcinoma and Its Correlation to the Biological Behavior of Gastric Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Deparment of Pathology, Lanzhou Medical College, Lanzhou 730000;

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Keywords：

Gastric carcinoma; cerb B2 gene; Cathepsin D; Lymph node metastasis; Depth of invasion; Prognosis

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Objective To investigate the expression of cerb B2 and CathepsinD in gastric carcinoma and its correlation with the biological behavior of gastric carcinoma (GC). MethodsThe expression was studied by immunohistochemical technique. The expression of cerb B2 and CathepsinD were analyzed with their relation to histologic types, depth of invasion, growth pattern, lymph node metastasis and prognosis of gastric carcinoma. ResultsThirtynine of the 102 gastric carcinoma specimens (38.24%) were positive for cerb B2 and correlated with depth of invasion (P＜0.05) and lymph node metastasis (P＜0.05); eightythree of the 102 gastric carcinoma specimens (81.37%) were positive for CathepsinD and correlated with depth of invasion (P＜0.05), growth pattern (P＜0.05), lymph node metastasis (P＜0.05) and blood vessels cancer embolus (P＜0.05). Prognosis of patients with gastric carcinoma with positive expression of cerb B2 or CathepsinD was poor. The 5year survival rate was significantly lower in gastric carcinoma patients with positive expression of cerb B2 or CathepsinD. Conclusion cerb B2 and CathepsinD are highly related to growth, invasion, metastasis and prognosis of gastric carcinoma.

Citation： LI Min,CHEN Jian,JIANG Min,et al. The Expression of cerb B2 and Cathepsin D in Gastric Carcinoma and Its Correlation to the Biological Behavior of Gastric Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 108-111. doi: Copy

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1. 陈艺华,董敬朋,李春德,等.人乳腺癌cerb B2基因扩增及过度表达的研究 [J].中华肿瘤杂志，1995; 17(1)∶16.
2. 万德森.cerb B2/neu基因表达水平与结、直肠癌预后的关系 [J].中山医科大学学报,1994; 15(2)∶120.
3. 山际裕史,马玉峰.胃的肠上皮化生及分化型腺癌EGF、EGFR、PCNA、cerb B2、p53及Kras的免疫组化染色研究 [J].国外医学分子生物学分册,1994; 16(6)∶283.
4. Akira MD,Masahiko MD,Takeshi MD,et al. Clinical significance of epidermal growth factor (EGF), EGF receptor, and cerb B2 in human gastric cancer [J].Cancer,1995; 75(6)∶1418.
5. Shinya MD,Hitoshi MD,Keiichi MD,et al. Overexpression of cerb B2 protein in gastric cancer [J].Cancer, 1993; 72(11)∶3179.
6. Garcia M,Deroc D,Pujol P,et al. Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency [J].Oncogene,1990; 5(12)∶1809.
7. McGuire WI, Tandon AK, Allred DC, et al. Prognosis and treatment decision in patients with breast cancer without axillary node involvement [J].Cancer,1992; 70(6 Supp1)∶1775.
8. Kiluk M,Skrzydlewski Z, Kiluk A, et al.Activity of cathepsin D in some neoplasms of gastrointestinal tract [J]. Pol Merkuriuszlek, 1997; 2(11)∶307.
9. Kantsaliev AL, Kozyreva EA, Kushlinskii NE, et al. Cathepsin D activity in gastric cancer [J]. Vopr Onkol,1994; 40(1-3)∶40.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Expression of cerb B2 and Cathepsin D in Gastric Carcinoma and Its Correlation to the Biological Behavior of Gastric Carcinoma

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