乳腺癌患者手术前后血浆可溶性P选择素的检测及意义△_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

刘剑勇 ¹ , 高月芳 ¹ , 覃宇周 ¹ , 吴飞翔 ¹ , 张力图 ² , 唐朝晖 ¹ , 李挺 ¹ , 杨南武 ¹

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Keywords：

乳腺癌; 手术; 可溶性P选择素

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可溶性P选择素可抑制多形核中性粒细胞通过整合素CD11b与血管内皮细胞粘附，有明显的控制炎症的作用［1］，也可介导某些肿瘤细胞与内皮细胞的粘附［2］，与肿瘤的发展和转移有关。为探讨血浆可溶性P选择素水平在乳腺癌患者手术前后的变化及意义，我们检测了42例乳腺癌患者手术前后血浆可溶性P选择素水平，现报道如下。
1资料与方法
正常对照组36例，男女各18例，年龄23~55岁，平均37.6岁，系健康体检者，于早晨取空腹静脉血。乳腺癌组42例，年龄27～68岁，平均47.6岁，均为临床Ⅱ期患者，并行根治性手术，其中行乳腺癌根治术15例，乳腺癌改良根治术27例。组织学类型：单纯癌29例，浸润性导管癌5例，髓样癌3例，硬癌3例，粘液腺癌2例。分别于术前1 d、术后第1 d、15 d和30 d早晨取空腹静脉血，应用可溶性P选择素ELISA试剂盒（苏州医学院血栓病研究所提供）检测血浆可溶性P选择素。所得数据用±s表示，用t检验和方差分析进行组间比较。

Citation： 刘剑勇,高月芳,覃宇周,吴飞翔,张力图,唐朝晖,李挺,杨南武. 乳腺癌患者手术前后血浆可溶性P选择素的检测及意义△. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 121-121. doi: Copy

1.	Gamble JR, Skinner MP, Bendall LJ, et al. Characterization of GMP140(Pselectin)as a circulating plasma protein [J].J Exp Med, 1992; 175(4)∶1147.
2.	Pottratz ST, Hall TD, Scribner WM, et al. Pselectin mediated attachment of small cell lung carcinoma to endothelian cells [J]. Am J Physiol, 1996; 217(5)∶ L918.
3.	Fox SB, Turner GD, Gatter KC, et al. The increased expression of adhesion molecules ICAM3, E and Pselectin on breast cancer endothelium [J].J Pathol, 1995; 177(4)∶369.
4.	Moor KL, Patel KD, Bruehl RE, et al. Pselectin glycoprotein ligand1 mediates rolling of human neutrophils on Pselectin [J].J Cell Biol, 1995; 128(3)∶ 661.
5.	Brock TA, Dvorak HF, Senger DR, et al. Tumorsecreted vascular permeability factor increase cytosolic Ca++and von Willebrand factor release in human endothelial cells [J]. Am J Pathol, 1995; 138(3)∶213.
6.	Vaki A. Selectins ligands [J]. Proc Natl Acad Sci USA, 1994; 91(23)∶7390.
7.	周同，陈晓，陈金联，等. P选择素在胃癌、肾癌中表达及其临床意义 [J]. 中华医学杂志， 1997； 77（7）∶530.
8.	Schadendorf D, Diehl S, Zuberbier T, et al. Quantitative detection of soluble adhesion molecules in sera melanoma patients correlates with clinical stage [J]. Dermatology, 1996; 192(2)∶89.

1. Gamble JR, Skinner MP, Bendall LJ, et al. Characterization of GMP140(Pselectin)as a circulating plasma protein [J].J Exp Med, 1992; 175(4)∶1147.
2. Pottratz ST, Hall TD, Scribner WM, et al. Pselectin mediated attachment of small cell lung carcinoma to endothelian cells [J]. Am J Physiol, 1996; 217(5)∶ L918.
3. Fox SB, Turner GD, Gatter KC, et al. The increased expression of adhesion molecules ICAM3, E and Pselectin on breast cancer endothelium [J].J Pathol, 1995; 177(4)∶369.
4. Moor KL, Patel KD, Bruehl RE, et al. Pselectin glycoprotein ligand1 mediates rolling of human neutrophils on Pselectin [J].J Cell Biol, 1995; 128(3)∶ 661.
5. Brock TA, Dvorak HF, Senger DR, et al. Tumorsecreted vascular permeability factor increase cytosolic Ca++and von Willebrand factor release in human endothelial cells [J]. Am J Pathol, 1995; 138(3)∶213.
6. Vaki A. Selectins ligands [J]. Proc Natl Acad Sci USA, 1994; 91(23)∶7390.
7. 周同，陈晓，陈金联，等. P选择素在胃癌、肾癌中表达及其临床意义 [J]. 中华医学杂志， 1997； 77（7）∶530.
8. Schadendorf D, Diehl S, Zuberbier T, et al. Quantitative detection of soluble adhesion molecules in sera melanoma patients correlates with clinical stage [J]. Dermatology, 1996; 192(2)∶89.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

乳腺癌患者手术前后血浆可溶性P选择素的检测及意义△

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