Advances in Mechanism of Multiple Organs Dysfunction During Acute Obstructive Cholangitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

GONG Jianping ¹ , HAN Benli ²

Department of General Surgery, The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010;

Corresponding author：

Keywords：

Acute obstructive cholangitis; Multiple organs dysfunction; Kupffer cells

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo elucidate the mechanism of multiple organs dysfunction (MOD) during acute obstructive cholangitis (AOC). MethodsThe reports about MOD and AOC in recent 10 years were collected and reviewed.ResultsApplicable animal models of AOC were established. During AOC, the decrease of Kupffer cells (KCs) phagocytic function and clearance function, hepatocyte mitochondrion damage, the effect of KCs on protein synthesis of hepatocytes and activation of KCs by endotoxin played an important role in the pathogenesis of MOD. ConclusionThe mechanism of pathogenesis of MOD during AOC is complicated and the changes of KCs functions is one of major factors.

Citation： GONG Jianping,HAN Benli. Advances in Mechanism of Multiple Organs Dysfunction During Acute Obstructive Cholangitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 133-135. doi: Copy

1.	Higure A, Okamoto K, Hirata K, et al. Macrophages and neutrophils infiltrating into the liver are responsible for tissue factor expression in a rabbit model of acute obstructive cholangitis \[J\]. Thromb Haemost, 1996; 75(5)∶ 791.
2.	Ou MC. Potential etiologic rule of PAF in two major septic complications: disseminated intravascular coagulation and multiple organ failure \[J\]. Thromb Res, 1994; 73(3-4)∶227.
3.	韩本立，龚建平，罗丁，等. 大鼠急性胆道感染动物模型的建立 \[J\]. 中华实验外科杂志，1992； 9（1）∶9.
4.	董家鸿，黄志强，韩本立，等. 实验性胆源性脓毒症的临床病理特征 \[J\]. 新消化病学杂志，1994； 2（3）∶140.
5.	Gong JP, Han BL, Luo D, et al. A study of Kupffer cell phagocytic function during acute obstructive cholangitis in rats \[J\]. J Med Coll PLA, 1991; 6(3)∶222.
6.	龚建平，韩本立，罗丁，等. 急性胆道感染时肠粘膜屏障损伤的研究 \[J\]. 中华实验外科杂志，1991； 8（3）∶115.
7.	龚建平，韩本立，李昆，等. 单核巨噬细胞在急性胆道感染所致肺损害中的作用 \[J\]. 第三军医大学学报，1993；15（1）∶1.
8.	陈平，韩本立，段恒春，等. 急性胆道感染时Kupffer细胞补体受体清除功能的研究 \[J\]. 中华实验外科杂志，1993； 10（2）∶88.
9.	Sun WB, Han BL, Li K, et al. A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats \[J\]. J Med Coll PLA, 1992; 7(6)∶109.
10.	Luo D, Han BL, Gong JP, et al. An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis \[J\]. J Med Coll PLA, 1991; 6(4)∶319.
11.	杨一增，韩本立，段恒春.急性胆管炎时枯否细胞对肝细胞蛋白合成功能的影响 \[J\]. 中华实验外科杂志， 1992； 9（增刊）∶139.
12.	李锐，韩本立，李昆，等. 急性胆管炎早期Kupffer细胞激活对肝细胞能量代谢的影响 \[J\]. 中华实验外科杂志，1995；12（6）∶321.
13.	龚建平，韩本立，彭志明，等. 大鼠急性胆道感染时多脏器损伤的病理学观察 \[J\]. 第三军医大学学报，1992； 14（2）∶107.
14.	李锐，韩本立. 巨噬细胞在严重胆道感染时肝肺损害发生机理中的作用 \[J\]. 第三军医大学学报，1994；16（4）∶309.
15.	Hasday JD, Dubin W, Mongovin S, et al. Bronchoalveolar macrophage CD14 expression: shift between membraneassociated and soluble pools \[J\]. Am J Physiol, 1997; 272(Lung Cell. Mol. Physiol. 16)∶L925.
16.	Liu S, Khemlani LS, Shapiro RA, et al. Expression of CD14 by hepatocytes: Upregulation by cytokines during endotoxemia \[J\]. Infection and Immunity, 1998; 66(11)∶5089.
17.	Bellezzo JM, Britton RS, Bacon BR, et al. LPSmediated NKkB activation in rat Kupffer cells can be induced independently of CD14 \[J\]. Am J Physiol, 1996; 270∶G956.
18.	Baldwin AS. The NFkB and IkB proteins: new discoveries and insights \[J\]. Ann Rev Immunol, 1996; 14∶649.
19.	May MJ, Ghosh S. Signal transduction through NFkB \[J\]. Immunology Today, 1998; 19(2)∶80.

1. Higure A, Okamoto K, Hirata K, et al. Macrophages and neutrophils infiltrating into the liver are responsible for tissue factor expression in a rabbit model of acute obstructive cholangitis \[J\]. Thromb Haemost, 1996; 75(5)∶ 791.
2. Ou MC. Potential etiologic rule of PAF in two major septic complications: disseminated intravascular coagulation and multiple organ failure \[J\]. Thromb Res, 1994; 73(3-4)∶227.
3. 韩本立，龚建平，罗丁，等. 大鼠急性胆道感染动物模型的建立 \[J\]. 中华实验外科杂志，1992； 9（1）∶9.
4. 董家鸿，黄志强，韩本立，等. 实验性胆源性脓毒症的临床病理特征 \[J\]. 新消化病学杂志，1994； 2（3）∶140.
5. Gong JP, Han BL, Luo D, et al. A study of Kupffer cell phagocytic function during acute obstructive cholangitis in rats \[J\]. J Med Coll PLA, 1991; 6(3)∶222.
6. 龚建平，韩本立，罗丁，等. 急性胆道感染时肠粘膜屏障损伤的研究 \[J\]. 中华实验外科杂志，1991； 8（3）∶115.
7. 龚建平，韩本立，李昆，等. 单核巨噬细胞在急性胆道感染所致肺损害中的作用 \[J\]. 第三军医大学学报，1993；15（1）∶1.
8. 陈平，韩本立，段恒春，等. 急性胆道感染时Kupffer细胞补体受体清除功能的研究 \[J\]. 中华实验外科杂志，1993； 10（2）∶88.
9. Sun WB, Han BL, Li K, et al. A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats \[J\]. J Med Coll PLA, 1992; 7(6)∶109.
10. Luo D, Han BL, Gong JP, et al. An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis \[J\]. J Med Coll PLA, 1991; 6(4)∶319.
11. 杨一增，韩本立，段恒春.急性胆管炎时枯否细胞对肝细胞蛋白合成功能的影响 \[J\]. 中华实验外科杂志， 1992； 9（增刊）∶139.
12. 李锐，韩本立，李昆，等. 急性胆管炎早期Kupffer细胞激活对肝细胞能量代谢的影响 \[J\]. 中华实验外科杂志，1995；12（6）∶321.
13. 龚建平，韩本立，彭志明，等. 大鼠急性胆道感染时多脏器损伤的病理学观察 \[J\]. 第三军医大学学报，1992； 14（2）∶107.
14. 李锐，韩本立. 巨噬细胞在严重胆道感染时肝肺损害发生机理中的作用 \[J\]. 第三军医大学学报，1994；16（4）∶309.
15. Hasday JD, Dubin W, Mongovin S, et al. Bronchoalveolar macrophage CD14 expression: shift between membraneassociated and soluble pools \[J\]. Am J Physiol, 1997; 272(Lung Cell. Mol. Physiol. 16)∶L925.
16. Liu S, Khemlani LS, Shapiro RA, et al. Expression of CD14 by hepatocytes: Upregulation by cytokines during endotoxemia \[J\]. Infection and Immunity, 1998; 66(11)∶5089.
17. Bellezzo JM, Britton RS, Bacon BR, et al. LPSmediated NKkB activation in rat Kupffer cells can be induced independently of CD14 \[J\]. Am J Physiol, 1996; 270∶G956.
18. Baldwin AS. The NFkB and IkB proteins: new discoveries and insights \[J\]. Ann Rev Immunol, 1996; 14∶649.
19. May MJ, Ghosh S. Signal transduction through NFkB \[J\]. Immunology Today, 1998; 19(2)∶80.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advances in Mechanism of Multiple Organs Dysfunction During Acute Obstructive Cholangitis

Abstract Full text Figures/Tables Video References Cited by

Format

Content