ObjectiveTo investigate the synergetic effects of the combination methylene blue or/and aprotinin on preventing postoperative intestinal adhesions (POIA).MethodsFourtyeight rabbits were divided into control group (group A), methylene blue group (group B), aprotinin group (group C), methylene blue+aprotinin group (group D). Each group contained 12 rabbits and established models of intestinal adhesions through laporotomy. Fourteen days after operation, the rabbits were reoperated to see whether there were adhesions and the degree of adhesions. ResultsThe adhesions of group A was the most serious, then in sequence were group B, C, group D showed very light adhesion. Group A was much more severe than B, C, D group (P lt;0.01); group D was very different from B, C group (P<0.05). ConclusionMethylene blue and aprotinin have significant effects on preventing POIA and the combination of the two drugs can have a synergetic effects on POIA.
Citation: DING Min,WANG Yuao,JIANG Sujun,et al.. Experimental Study on Preventing Postoperative Intestinal Adhesions by Methylene Blue and Aprotinin. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(3): 175-176. doi: Copy