Advances of Treating Noumenon Tumor by AntiAngiogenesis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041;

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Keywords：

AngiogenesisAntiangiogenesisMicrovessel densityTumorGene therapy

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ObjectiveTo discuss the feasibility of treating noumenon tumor by antiangiogenesis.MethodsRelated literatures of recent 5 years was reviewed.ResultsTumor angiogenesis were related closely with growth, development, metastasis and prognosis of noumenon tumor. It was possible to inhibit the growth and metastasis of noumenon tumor with antiangiogenesis in vitro and vivo.ConclusionAntiangiogenesis will be a new therapy of treating noumenon tumor.

Citation： LI Hongjiang,ZHAO Yangbing. Advances of Treating Noumenon Tumor by AntiAngiogenesis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(3): 207-209. doi: Copy

1.	Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in earlystage breast carcinoma [Ｊ]. J Natl Cancer Inst, 1992; 84(24)∶1875.
2.	Folkman J. Diagnostic and therapeutic applications of angiogenesis research [Ｊ]. C R Acad Sci Paris Ⅲ, 1993; 316(9)∶914.
3.	Battegay EJ. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects [Ｊ]. J Mol Med, 1995; 73(7)∶333.
4.	董为人，彭必友，李进，等. 细胞粘附与血管生成 [Ｊ].国外医学外科学分册，1998； 25（1）∶29.
5.	Guinebretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease [Ｊ]. J Natl Cancer Inst, 1994; 86(8)∶635.
6.	李宏江，敬静，朱精强，等. 乳腺疾病中微血管的观察分析 [Ｊ]. 中国普外基础与临床杂志，1999； 6（5）∶285.
7.	李宏江，赵扬冰，张世羽，等. 微血管检测对乳腺癌患者预后的预示价值 [Ｊ]. 中华实验外科杂志，1999； 16（增）∶49.
8.	Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment [Ｊ]. Ann Surg, 1966; 164(3)∶491.
9.	Brooks PC, Stromblad S, Klemke R, et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin [Ｊ]. J Clin Invest, 1995; 96(4)∶1815.
10.	Im SA, GomezManzano C, Fueyo J, et al. Antiangiogenesis treatment for gliomas: transfer of antisensevascular endothelial growth factor inhibits tumor growth in vivo [Ｊ]. Cancer Res, 1999; 59(4)∶895.
11.	章翔，吴景文，高大宽，等. 血管内皮生长因子165反义RNA治疗人脑胶质瘤的实验研究 [Ｊ].中华医学杂志，2000； 80（5）∶386.
12.	Borgstrom P, Bourdon MA, Hillan KJ, et al. Neutralizing antivascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo [Ｊ]. Prostate, 1998; 35(1)∶1.
13.	Goldman CK, Kendall RL, Cabrera G, et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8795.
14.	Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endotheliumspecific receptor tyrosine kinase Tie2[Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8829.
15.	宋述梅，寿成超. 原核表达的可溶性血管内皮生长因子受体对血管内皮生长因子活性的抑制 [Ｊ].中华医学杂志， 2000； 80（3）∶226.
16.	Lin H, Lu H, Griscelli F, et al. Adenovirusmediated delivery of a uPA/uPAR antagonist suppresses angiogenesisdependent tumor growth and dissemination in mice [Ｊ]. Gene Ther, 1998; 5(8)∶1105.
17.	Griscelli F, Li H, BennaceurGriscelli A, et al. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(11)∶6367.
18.	Valente P, Fassina G, Melchiori A, et al. TIMP2 overexpression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis [Ｊ]. Int J Cancer, 1998; 75(2)∶246.
19.	Zabrenetzky V, Harris CC, Steeg PS, et al. Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines [Ｊ]. Int J Cancer, 1994; 59(2)∶191.
20.	Zajchowcki DA, Band V, Trask DK, et al. Suppression of tumorforming ability and related traits in MCF7 human breast cancer cells by fusion with immortal mammary epithelial cells [Ｊ]. Proc Natl Acad Sci USA, 1990; 87(6)∶2314.
21.	郭文忠，杨治华，刘军，等. 血管形成抑制因子HIAF1的克隆及其抗肿瘤作用 [Ｊ]. 中华肿瘤杂志， 2000； 22（1）∶19.
22.	Singh Y, Shikata N, Kiyozuka Y, et al. Inhibition of tumor growth and metastasis by angiogenesis inhibitor TNP470 on breast cancer cell lines in vitro and in vivo [Ｊ]. Breast Cancer Res Treat, 1997; 45(1)∶15.
23.	夏景林，任正刚，杨秉辉，等. 血管形成抑制剂TNP470对肝癌组织VEGF表达的影响 [Ｊ]. 中华肿瘤杂志，2000； 22（1）∶26.

1. Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in earlystage breast carcinoma [Ｊ]. J Natl Cancer Inst, 1992; 84(24)∶1875.
2. Folkman J. Diagnostic and therapeutic applications of angiogenesis research [Ｊ]. C R Acad Sci Paris Ⅲ, 1993; 316(9)∶914.
3. Battegay EJ. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects [Ｊ]. J Mol Med, 1995; 73(7)∶333.
4. 董为人，彭必友，李进，等. 细胞粘附与血管生成 [Ｊ].国外医学外科学分册，1998； 25（1）∶29.
5. Guinebretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease [Ｊ]. J Natl Cancer Inst, 1994; 86(8)∶635.
6. 李宏江，敬静，朱精强，等. 乳腺疾病中微血管的观察分析 [Ｊ]. 中国普外基础与临床杂志，1999； 6（5）∶285.
7. 李宏江，赵扬冰，张世羽，等. 微血管检测对乳腺癌患者预后的预示价值 [Ｊ]. 中华实验外科杂志，1999； 16（增）∶49.
8. Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment [Ｊ]. Ann Surg, 1966; 164(3)∶491.
9. Brooks PC, Stromblad S, Klemke R, et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin [Ｊ]. J Clin Invest, 1995; 96(4)∶1815.
10. Im SA, GomezManzano C, Fueyo J, et al. Antiangiogenesis treatment for gliomas: transfer of antisensevascular endothelial growth factor inhibits tumor growth in vivo [Ｊ]. Cancer Res, 1999; 59(4)∶895.
11. 章翔，吴景文，高大宽，等. 血管内皮生长因子165反义RNA治疗人脑胶质瘤的实验研究 [Ｊ].中华医学杂志，2000； 80（5）∶386.
12. Borgstrom P, Bourdon MA, Hillan KJ, et al. Neutralizing antivascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo [Ｊ]. Prostate, 1998; 35(1)∶1.
13. Goldman CK, Kendall RL, Cabrera G, et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8795.
14. Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endotheliumspecific receptor tyrosine kinase Tie2[Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8829.
15. 宋述梅，寿成超. 原核表达的可溶性血管内皮生长因子受体对血管内皮生长因子活性的抑制 [Ｊ].中华医学杂志， 2000； 80（3）∶226.
16. Lin H, Lu H, Griscelli F, et al. Adenovirusmediated delivery of a uPA/uPAR antagonist suppresses angiogenesisdependent tumor growth and dissemination in mice [Ｊ]. Gene Ther, 1998; 5(8)∶1105.
17. Griscelli F, Li H, BennaceurGriscelli A, et al. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(11)∶6367.
18. Valente P, Fassina G, Melchiori A, et al. TIMP2 overexpression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis [Ｊ]. Int J Cancer, 1998; 75(2)∶246.
19. Zabrenetzky V, Harris CC, Steeg PS, et al. Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines [Ｊ]. Int J Cancer, 1994; 59(2)∶191.
20. Zajchowcki DA, Band V, Trask DK, et al. Suppression of tumorforming ability and related traits in MCF7 human breast cancer cells by fusion with immortal mammary epithelial cells [Ｊ]. Proc Natl Acad Sci USA, 1990; 87(6)∶2314.
21. 郭文忠，杨治华，刘军，等. 血管形成抑制因子HIAF1的克隆及其抗肿瘤作用 [Ｊ]. 中华肿瘤杂志， 2000； 22（1）∶19.
22. Singh Y, Shikata N, Kiyozuka Y, et al. Inhibition of tumor growth and metastasis by angiogenesis inhibitor TNP470 on breast cancer cell lines in vitro and in vivo [Ｊ]. Breast Cancer Res Treat, 1997; 45(1)∶15.
23. 夏景林，任正刚，杨秉辉，等. 血管形成抑制剂TNP470对肝癌组织VEGF表达的影响 [Ｊ]. 中华肿瘤杂志，2000； 22（1）∶26.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advances of Treating Noumenon Tumor by AntiAngiogenesis

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