Integrin and Tumor Angiogenesis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016;

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Keywords：

IntegrinAngiogenesisVascular growth factor

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Objective To evaluate the role for integrins in tumor angiogenesis. MethodsLiteratures in recent years were reviewed. ResultsIntegrins played an important role in tumor angiogenesis and integrins had a close relation to vascular growth factors. Conclusion Inhibitors of integrins will be a promising way to cure tumors.

Citation： GAO Rui,YAO Zhenxiang. Integrin and Tumor Angiogenesis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(3): 213-214. doi: Copy

1.	Springer TA. Folding of the Nterminal, ligandbinding region of integrin αsubunit into a bpropeller domain [J]. Proc Natl Acad Sci USA, 1997; 94(1)∶65.
2.	Mizejewski GJ. Role of integrin in cancer: survey of expression patterns [J]. Proc Soc Exp Bio Med, 1999; 222(2)∶124.
3.	Mizejewske GJ. Afeteprotein as a biologic response modifier: relevance to domain and subdomain structure [J]. Proc Soc Exp Bio Med, 1997; 215(4)∶333.
4.	Gui GP, Puddlegoot JR, Vinson GP, et al. In vitro regulation of human breast cancer cell adhesion and invasion via integrin receptors to the extracellular matrix [J]. Br J Surg, 1995; 82(9)∶1192.
5.	Drake CJ, Cheresh DA, Little CD. A antagonist of integrin αⅤβ3 prevent maturations of blood vessels during embryonic neovascularization [J]. J Cell Science, 1995; 108(pt 7)∶2655.
6.	Carron CP, Meyer DM, Pegg JA, et al. A peptidomimetic antagonist of the integrin αⅤβ3 inhibits leydig cell tumor growth and the development of hypercalcemia of malignanoy [J]. Cancer Res, 1998; 58(9)∶1930.
7.	Kerr JS, Wexler RS, Mousa SA, et al. Novel small molecue αⅤ integrin antagonists comparative anticancer efficacy with known angiogenesis inhibitors [J]. Anticancer Res, 1999; 19(2a)∶959.
8.	Stromblad S, Becker JC, Yebra M. Suppresion of p53 activity and p21WAF/CIP1 expression by vascular cell integrin αⅤβ3 during angiogenesis [J].J Clin Investig, 1996; 7(2)∶426.
9.	Petitclerc E, Stromblad S, Von Schalscha TL, et al. Integrin αⅤβ3 promotes M21 melanoma growth in human skin by regulating tumor cell survival [J]. Cancer Res, 1999; 59(11)∶2724.
10.	Lew JM, Cheresh DA, Schwartz MA. Protein kinase C regulates αⅤβ5 dependent cytokeletal association and focal adhesion kinase phosphorylation [J]. J Cell Biol, 1999; 134(5)∶1323.
11.	Yebra M, Parrg GCN, Stromblad S, et al. Requirement of receptor bound urokinase type plasminogen activator for integrin αⅤβ5 directed cell migration [J]. J Biol Chem, 1996; 271(46)∶29393.
12.	Kim S, Bell K, Mousa SA, et al. Regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell binding domain of fibronectin [J]. Am J Patho, 2000; 156(4)∶1345.
13.	Scheller M, Vuoric K, Ruoslahti E. α5β3 integrin associates with activated insulin and PDGF beta receptors and potentiates the biological activity of PDGF [J]. EMBO J, 1997; 16(18)∶5600.
14.	Donald R, Kevin P, Julie E, et al. Angiogenesis promoted by vascular endothelial growth factor: regulation through α1β1 and α2β1 integrins [J]. Proc Natl Acad Sci USA, 1997; 94(pp)∶13612.
15.	Senger DR, Ledbetter SR, Claffey KP, et al. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanism involving the αⅤβ3 integrin, osteoponin and thrombin [J]. Am J Pathol, 1996; 149(1)∶293.
16.	Sato Y. Transciption factor ETS1 as a molecular target for angiogenesis inhibition [J]. Hum Cell, 1998; 11(4)∶207.
17.	Brooks PC, Montgomery AM, Rosenfeld M, et al. Integrin alpha Ⅴ beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels [J]. Cell, 1994; 79(7)∶1157.
18.	Chiang HS, Swaim MW, Huang TF. Characterization of platelet aggregation induced by human colon adenocarcinoma cell and its inhibition by snake venom peptides trigramin and rhdostomin [J]. Breast Cancer Res Treat, 1995; 33(3)∶225.
19.	Dechantsreiter MA, Planker E, Matha B, et al. Nmethylated cyclic RGD reptides as highly active and selective αⅤβ3 integrin antagonists [J]. J Med Chem, 1999; 42(16)∶3033.

1. Springer TA. Folding of the Nterminal, ligandbinding region of integrin αsubunit into a bpropeller domain [J]. Proc Natl Acad Sci USA, 1997; 94(1)∶65.
2. Mizejewski GJ. Role of integrin in cancer: survey of expression patterns [J]. Proc Soc Exp Bio Med, 1999; 222(2)∶124.
3. Mizejewske GJ. Afeteprotein as a biologic response modifier: relevance to domain and subdomain structure [J]. Proc Soc Exp Bio Med, 1997; 215(4)∶333.
4. Gui GP, Puddlegoot JR, Vinson GP, et al. In vitro regulation of human breast cancer cell adhesion and invasion via integrin receptors to the extracellular matrix [J]. Br J Surg, 1995; 82(9)∶1192.
5. Drake CJ, Cheresh DA, Little CD. A antagonist of integrin αⅤβ3 prevent maturations of blood vessels during embryonic neovascularization [J]. J Cell Science, 1995; 108(pt 7)∶2655.
6. Carron CP, Meyer DM, Pegg JA, et al. A peptidomimetic antagonist of the integrin αⅤβ3 inhibits leydig cell tumor growth and the development of hypercalcemia of malignanoy [J]. Cancer Res, 1998; 58(9)∶1930.
7. Kerr JS, Wexler RS, Mousa SA, et al. Novel small molecue αⅤ integrin antagonists comparative anticancer efficacy with known angiogenesis inhibitors [J]. Anticancer Res, 1999; 19(2a)∶959.
8. Stromblad S, Becker JC, Yebra M. Suppresion of p53 activity and p21WAF/CIP1 expression by vascular cell integrin αⅤβ3 during angiogenesis [J].J Clin Investig, 1996; 7(2)∶426.
9. Petitclerc E, Stromblad S, Von Schalscha TL, et al. Integrin αⅤβ3 promotes M21 melanoma growth in human skin by regulating tumor cell survival [J]. Cancer Res, 1999; 59(11)∶2724.
10. Lew JM, Cheresh DA, Schwartz MA. Protein kinase C regulates αⅤβ5 dependent cytokeletal association and focal adhesion kinase phosphorylation [J]. J Cell Biol, 1999; 134(5)∶1323.
11. Yebra M, Parrg GCN, Stromblad S, et al. Requirement of receptor bound urokinase type plasminogen activator for integrin αⅤβ5 directed cell migration [J]. J Biol Chem, 1996; 271(46)∶29393.
12. Kim S, Bell K, Mousa SA, et al. Regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell binding domain of fibronectin [J]. Am J Patho, 2000; 156(4)∶1345.
13. Scheller M, Vuoric K, Ruoslahti E. α5β3 integrin associates with activated insulin and PDGF beta receptors and potentiates the biological activity of PDGF [J]. EMBO J, 1997; 16(18)∶5600.
14. Donald R, Kevin P, Julie E, et al. Angiogenesis promoted by vascular endothelial growth factor: regulation through α1β1 and α2β1 integrins [J]. Proc Natl Acad Sci USA, 1997; 94(pp)∶13612.
15. Senger DR, Ledbetter SR, Claffey KP, et al. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanism involving the αⅤβ3 integrin, osteoponin and thrombin [J]. Am J Pathol, 1996; 149(1)∶293.
16. Sato Y. Transciption factor ETS1 as a molecular target for angiogenesis inhibition [J]. Hum Cell, 1998; 11(4)∶207.
17. Brooks PC, Montgomery AM, Rosenfeld M, et al. Integrin alpha Ⅴ beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels [J]. Cell, 1994; 79(7)∶1157.
18. Chiang HS, Swaim MW, Huang TF. Characterization of platelet aggregation induced by human colon adenocarcinoma cell and its inhibition by snake venom peptides trigramin and rhdostomin [J]. Breast Cancer Res Treat, 1995; 33(3)∶225.
19. Dechantsreiter MA, Planker E, Matha B, et al. Nmethylated cyclic RGD reptides as highly active and selective αⅤβ3 integrin antagonists [J]. J Med Chem, 1999; 42(16)∶3033.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Integrin and Tumor Angiogenesis

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