The Development of Methods Assessing Donor Liver Viability in Liver Transplantation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, The Second Affiliated Hospital of Jiangxi Medical College, Nanchang 330006;

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Keywords：

Liver transplantation; Donor liver; Viability; Method

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ObjectiveTo study the development of methods assessing donor liver viability in liver transplantation.MethodsThe literature in the recent years on the methods of assessing donor liver viability was reviewed.ResultsFrom donor liver morphology to function,there have being developed many methods which assess donor liver viability,including:①donor liver appearance; ②intraoperative biopsies; ③donor liver microcirculation; ④portal pressure; ⑤enzymes levels in liver; ⑥lidocainemetabolizing activity; ⑦energy metabolism of donor liver; ⑧fat content in donor liver.ConclusionThere are many methods to assess the viability of donor liver. Each has its supericrity and defect respectively. Intraoperative biopsies, 31Pmagnetic resonance spectroscopy and portal pressure have more importance in clinical application.

Citation： SHU Ming,XIONG Benjing,FU Huaqun.. The Development of Methods Assessing Donor Liver Viability in Liver Transplantation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(4): 285-287. doi: Copy

1.	D’Alessandro AM, Kalayoglu M, Sollinger HW, et al. The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation [J].Transplantation,1991; 51(1)∶157.
2.	Gaffey MJ,Boyd JC,Traweek T,et al.Predictive value of intraoperative biopsies and liver function tests for preservation injury in orthotopic liver transplantation [J]. Hepatology,1997; 25(1)∶184.
3.	Garcia Urena MA,Colina RuizDelgado F,Moreno Gonzalez E,et al. Hepatic steatosis in liver transplant donors:common feature of donor population? [J]. World J Surg,1998; 22(8)∶837.
4.	Langer S,Harris AG,Biberthaler P, et al.Orthogonal polarization spectral imaging as a tool for the assessment of hepatic microcirculation a validation study [J].Transplantation,2001; 71(9)∶1249.
5.	韩德恩，曾兆林，陈嘉薇，等. 大鼠供肝质量的快速评价方法 [J].中华器官移植杂志,2000; 21(3)∶168.
6.	Hamamoto I,Nemoto EM,Zhang S,et al.Assessment of hepatic viability during cold ischemic preservation [J].Transpl Int,1995; 8(2)∶434.
7.	Higashi H,Yanaga K,Shimada M,et al. Plasma lecithin/cholesterol acyltransferase (LCAT) activity in multipleorgan donors: a predictor of allograft viability in clinicial liver transplantation [J].Transplant Proc,1990; 22(2)∶433.
8.	Soejima Y,Yanaga K,Wakiyama S,et al.Serum hyaluronic acid as a reliable parameter of allograft viability in porcine liver transplantation [J].Hepatogastroenterology,1996; 43(3)∶590.
9.	Jacobsen IA,Pegg DE.Kidney.In: Karrow AM,Pegg DE,eds.Organ preservation for transplantation [M].USA:Marcel Dekker,1981∶553-554.
10.	Mets B,Hickman R,Allin R,et al. Effect of hypoxia on the hepatic metabolism of lidocaine in the isolated perfused pig liver [J]. Hepatology,1993; 17(4)∶668.
11.	Izuishi K, Wakabayashi H,Maeba T, et al. Lidocainemetabolizing activity after warm ischemia and reperfusion of the rat liver in vivo [J].World J Surg,2000; 24(1)∶49.
12.	Kamiike W, Burdelski M, Steinhoff G,et al. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation [J]. Transplantation,1988; 45(1)∶138.
13.	Harvey PR,Iu S, McKeown CM,et al.Adenine nucleotide tissue concentrations and liver allograft viability after cold preservation and warm ischemia [J].Transplantation,1988; 45(6)∶1016.
14.	Ozawa K,Fujimoto T,Nakatani T,et al.Changes in hepatic energy charge,blood ketone body ratio,and indocyanine green clearance in relation to DNA synthesis after hepatectomy [J].Life Sci,1982; 31(7)∶ 647.
15.	Ozawa K,Aoyama H,Yasuda K,et al. Metabolic abnormalities associated with postoperative organ failure. A redox theory [J].Arch Surg,1983; 118(11)∶1245.
16.	Hamamoto I,Takaya S,Todo S,et al.Can adenine nucleotides predict primary nonfunction of the human liver homograft [J]. Transplant Proc,1993; 25(6)∶3036.
17.	Wolf RF, Kamman RL,Mooyaart EL,et al.31Pmagnetic resonance spectroscopy of the isolated human donor liverfeasibility in routine clinical practice and preliminary findings [J]. Transplantation, 1993; 55(4)∶949.
18.	Fuller BJ,Busza AL,Proctor E.Possible resuscitation of liver function by hypothermic reperfusion in vitro after prolonged(24hour)cold preservation: a 31PNMR study [J].Transplantation,1990; 50(3)∶511.
19.	Wolf RF,Haagsma EB, Kamman RL, et al.Noninvasive metabolic assessment of human donor livers: prognostic value of 31Pmagnetic resonance spectroscopy for early graft function [J]. Transplantation,1997; 64(1)∶147.
20.	Scarpa M, Corazza A,Vianello F,et al.Deuterium nuclear magnetic resonance for evaluting the metabolic status of livers subjected to warm ischemia [J].Transplantation,2001; 71(11)∶1515.
21.	Net M,Valero R,Almenara R,et al.Hepatic xanthine levels as viability predictor of livers procured from nonheartbeating donor pigs [J].Transplantation, 2001; 71(9)∶1232.
22.	Markin RS, Wisecarver JL, Radio SJ, et al. Frozen section evaluation of donor livers before transplantation [J].Transplantation,1993; 56(6)∶1403.
23.	Todo S,Demetris AJ,Makowka L,et al.Primary nonfunction of hepatic allografts with preexisting fatty infiltration [J].Transplantation,1989; 47(5)∶903.
24.	Adam R, Reynes M, Johann M, et al.The outcome of steatotic grafts in liver transplantation [J].Transplant Proc, 1991; 23(1 Pt 2)∶1538.
25.	Fishbein TM, Fiel MI, Emre S, et al. Use of livers with microvesicular fat safely expands the donor pool [J].Transplantation,1997; 64(2)∶248.
26.	Kitai T, Beauvoit B, Chance B.Optical deterrmination of fatty change of the graft liver with nearinfrared timeresolved spectroscopy [J].Transplantation, 1996; 62(5)∶642.
27.	Cheng YF,Chen CL,Lai CY,et al.Assessment of donor fatty livers for liver transplantation [J].Transplantation,2001; 71(9)∶1221.

1. D’Alessandro AM, Kalayoglu M, Sollinger HW, et al. The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation [J].Transplantation,1991; 51(1)∶157.
2. Gaffey MJ,Boyd JC,Traweek T,et al.Predictive value of intraoperative biopsies and liver function tests for preservation injury in orthotopic liver transplantation [J]. Hepatology,1997; 25(1)∶184.
3. Garcia Urena MA,Colina RuizDelgado F,Moreno Gonzalez E,et al. Hepatic steatosis in liver transplant donors:common feature of donor population? [J]. World J Surg,1998; 22(8)∶837.
4. Langer S,Harris AG,Biberthaler P, et al.Orthogonal polarization spectral imaging as a tool for the assessment of hepatic microcirculation a validation study [J].Transplantation,2001; 71(9)∶1249.
5. 韩德恩，曾兆林，陈嘉薇，等. 大鼠供肝质量的快速评价方法 [J].中华器官移植杂志,2000; 21(3)∶168.
6. Hamamoto I,Nemoto EM,Zhang S,et al.Assessment of hepatic viability during cold ischemic preservation [J].Transpl Int,1995; 8(2)∶434.
7. Higashi H,Yanaga K,Shimada M,et al. Plasma lecithin/cholesterol acyltransferase (LCAT) activity in multipleorgan donors: a predictor of allograft viability in clinicial liver transplantation [J].Transplant Proc,1990; 22(2)∶433.
8. Soejima Y,Yanaga K,Wakiyama S,et al.Serum hyaluronic acid as a reliable parameter of allograft viability in porcine liver transplantation [J].Hepatogastroenterology,1996; 43(3)∶590.
9. Jacobsen IA,Pegg DE.Kidney.In: Karrow AM,Pegg DE,eds.Organ preservation for transplantation [M].USA:Marcel Dekker,1981∶553-554.
10. Mets B,Hickman R,Allin R,et al. Effect of hypoxia on the hepatic metabolism of lidocaine in the isolated perfused pig liver [J]. Hepatology,1993; 17(4)∶668.
11. Izuishi K, Wakabayashi H,Maeba T, et al. Lidocainemetabolizing activity after warm ischemia and reperfusion of the rat liver in vivo [J].World J Surg,2000; 24(1)∶49.
12. Kamiike W, Burdelski M, Steinhoff G,et al. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation [J]. Transplantation,1988; 45(1)∶138.
13. Harvey PR,Iu S, McKeown CM,et al.Adenine nucleotide tissue concentrations and liver allograft viability after cold preservation and warm ischemia [J].Transplantation,1988; 45(6)∶1016.
14. Ozawa K,Fujimoto T,Nakatani T,et al.Changes in hepatic energy charge,blood ketone body ratio,and indocyanine green clearance in relation to DNA synthesis after hepatectomy [J].Life Sci,1982; 31(7)∶ 647.
15. Ozawa K,Aoyama H,Yasuda K,et al. Metabolic abnormalities associated with postoperative organ failure. A redox theory [J].Arch Surg,1983; 118(11)∶1245.
16. Hamamoto I,Takaya S,Todo S,et al.Can adenine nucleotides predict primary nonfunction of the human liver homograft [J]. Transplant Proc,1993; 25(6)∶3036.
17. Wolf RF, Kamman RL,Mooyaart EL,et al.31Pmagnetic resonance spectroscopy of the isolated human donor liverfeasibility in routine clinical practice and preliminary findings [J]. Transplantation, 1993; 55(4)∶949.
18. Fuller BJ,Busza AL,Proctor E.Possible resuscitation of liver function by hypothermic reperfusion in vitro after prolonged(24hour)cold preservation: a 31PNMR study [J].Transplantation,1990; 50(3)∶511.
19. Wolf RF,Haagsma EB, Kamman RL, et al.Noninvasive metabolic assessment of human donor livers: prognostic value of 31Pmagnetic resonance spectroscopy for early graft function [J]. Transplantation,1997; 64(1)∶147.
20. Scarpa M, Corazza A,Vianello F,et al.Deuterium nuclear magnetic resonance for evaluting the metabolic status of livers subjected to warm ischemia [J].Transplantation,2001; 71(11)∶1515.
21. Net M,Valero R,Almenara R,et al.Hepatic xanthine levels as viability predictor of livers procured from nonheartbeating donor pigs [J].Transplantation, 2001; 71(9)∶1232.
22. Markin RS, Wisecarver JL, Radio SJ, et al. Frozen section evaluation of donor livers before transplantation [J].Transplantation,1993; 56(6)∶1403.
23. Todo S,Demetris AJ,Makowka L,et al.Primary nonfunction of hepatic allografts with preexisting fatty infiltration [J].Transplantation,1989; 47(5)∶903.
24. Adam R, Reynes M, Johann M, et al.The outcome of steatotic grafts in liver transplantation [J].Transplant Proc, 1991; 23(1 Pt 2)∶1538.
25. Fishbein TM, Fiel MI, Emre S, et al. Use of livers with microvesicular fat safely expands the donor pool [J].Transplantation,1997; 64(2)∶248.
26. Kitai T, Beauvoit B, Chance B.Optical deterrmination of fatty change of the graft liver with nearinfrared timeresolved spectroscopy [J].Transplantation, 1996; 62(5)∶642.
27. Cheng YF,Chen CL,Lai CY,et al.Assessment of donor fatty livers for liver transplantation [J].Transplantation,2001; 71(9)∶1221.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Development of Methods Assessing Donor Liver Viability in Liver Transplantation

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