Effect of Ginsenoside Rg3 Combined with Cytotoxic Agent on the Progression of Xenotransplanted Human Breast Infiltrating Duct Carcinoma in Nude Mice_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041;

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Keywords：

GinsenosideHuman breast infiltrating duct carcinomaXenotransplantationCytotoxic agentMicrovessel density

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ObjectiveTo study the mechanism of reducing the intratumoral microvessel density (MVD) by Ginsenoside Rg3 (Rg3) combined with cytotoxic agent in xenotransplanted human breast infiltrating duct carcinoma in nude mice. MethodsSixteen female nude mice were randomly divided into 4 groups to receive cyclophosphamid (16 mg/kg,qd) combined with Rg3 (10 mg/kg, qd),Rg3(10 mg/kg,qd) alone,cyclophosphamid (16 mg/kg,qd) alone and 0.5% sodium carboxymethyl cellulose (0.5 ml,qd) respectively for 55 days. Breast cancer mass were weighed and sampled for light microscopic observation. The intratumor MVD was examined by immunohistochemical staining. ResultsThe tumor weight of treated group was significantly lower than that of control group. The tumor weight of the Rg3 combined with CTX group was lower than that of Rg3 group. The MVD value of Rg3 group was significantly lower than that of CTX group and control group. The MVD was significantly reduced in the Rg3 combined with CTX group than that in the others.ConclusionRg3 combined with CTX can inhibit the growth of xenotransplanted human breast infiltrating duct carcinoma, and reduce the intratumoral MVD.

Citation： CHEN Dafu,ZHAO Yangbing,BAI Shaohuai,et al.. Effect of Ginsenoside Rg3 Combined with Cytotoxic Agent on the Progression of Xenotransplanted Human Breast Infiltrating Duct Carcinoma in Nude Mice. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 300-302. doi: Copy

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1. Mochizuki M, Yoo YC, Matsuzawa K, et al. Inhibitory effect of tumor metastasis in mice by saponins, ginsenosideRb2, 20(R)and 20(S)ginsenosideRg3, of red ginseng \[J\]. Biol Pharm Bull，1995； 18(9)∶1197.
2. 高勇，王杰军，许青，等.人参皂甙Rg3抑制肿瘤新生血管形成机制研究 \[J\].第二军医大学学报，2001； 22（1）∶40.
3. 白绍槐，赵扬冰，张旋波，等，人乳腺浸润性导管癌裸鼠移植模型的建立 \[J\].华西医科大学学报，1999； 30（2）∶220.
4. Gasparini G, Harris AL. Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool \[J\]. J Clin Oncol,1995； 13（3）∶765.
5. Gasparini G, Biganzoli E， Bonoldi E， et al. Angiogenesis sustains tumor dormancy in patients with breast cancer treated with adjuvant chemotherapy \[J\]. Breast Cancer Res Treat， 2001； 65（1）∶71.
6. Teicher BA， Holden SA, Ara G, et al. Potentiation of cytotoxic cancer therapies by TNP470 alone and with other antiangiogenic agents \[J\]. Int J Cancer，1994； 57（6）∶920.
7. Kachel DL, Martin WJ 2nd. Cyclophosphamideinduced lung toxicity: mechanism of endothelial cell injury \[J\]. J Pharmacol Exp Ther, 1994; 268（1）∶42.
8. Brem H，Gresser I, Grosfeld J, et al. The combination of antiangiogenic agents to inhibit primary tumor growth and metastasis \[J\]. J Pediatr Surg, 1993； 28（10）∶1253.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Ginsenoside Rg3 Combined with Cytotoxic Agent on the Progression of Xenotransplanted Human Breast Infiltrating Duct Carcinoma in Nude Mice

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