Estrogen Receptor Beta and Advances in Breast Cancer Research_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, West China Hospital， Sichuan University, Chengdu 610041;

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Estrogen receptor β Breast cancer

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ObjectiveTo review recent studies on the roles of estrogen receptor β in breast cancer. MethodsThe literatures in recent years on the biological function, variant isoforms of estrogen receptor and its possible roles in breast cancer were reviewed. ResultsERβ was a new member of the superfamily of steroid receptors, it might play an important role in breast tumor genesis, tumor progression, prognosis and reaction to the endocrine therapy in breast cancer. ConclusionERβ is a new prognostic marker in breast cancer.

Citation： CHEN Lin,YANG Jinqiao.. Estrogen Receptor Beta and Advances in Breast Cancer Research. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 358-360. doi: Copy

1.	Kuiper GG, Enmark E, PeltoHuikko M, et al. Cloning of a novel receptor expressed in rat prostate and ovary [J]. Proc Natl Acad Sci USA, 1996; 93(12)∶5925.
2.	Mosselman S, Polman J, Dijkema R. ER beta: identification and characterization of a novel human estrogen receptor [J]. FEBS Lett,1996; 392(1)∶49.
3.	Tremblay GB, Tremblay A, Copeland NG, et al. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta [J]. Mol Endocrinol, 1997; 11(3)∶353.
4.	Enmark E, PeltoHuikko M, Grandien K, et al. Human estrogen receptor betagene structure, chromosomal localization， and expression pattern [J]. J Clin Endocrinol Metab,1997; 82(12)∶4258.
5.	Gustafsson JA. Estrogen receptor betaa new dimension in estrogen mechanism of action [J]. J Endocrinol,1999; 163(3)∶379.
6.	Kuiper GG, Carlsson B, Grandien K, et al. Comparision of the ligand binding specificity and transcript tissue distribution of estrogen receptor alpha and beta [J]. Endocrinology,1997; 138(3)∶863.
7.	Cowley SM, Hoare S, Mosselman S, et al.Estrogen receptors alpha and beta form heterodimers on DNA [J]. J Biol Chem,1997; 272(32)∶19858.
8.	Pace P, Taylor J, Suntharalingam S, et al. Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha [J].J Biol Chem,1997; 272(41)∶25832.
9.	Gaub MP，Bellard M, Scheuer I，et al. Activation of the ovalbumin gene by the estrogen receptor involves the fosjun complex [J].Cell 1990; 63(6)∶1267.
10.	Paech K, Webb P, Kuiper GG,et al. Differential ligand activation of estrogen receptors ERalpha and ER beta at AP1 sites [J]. Science, 1997; 277(5331)∶1508.
11.	Hall JM, McDonnell DP. The estrogen receptor betaisoform (ER beta) of the human estrogen receptor modulates ER alpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens [J].Endocrinology, 1999; 140(12)∶5566.
12.	Dotzlaw H, Leygue E, Watson PH, et al. Expression of estrogen receptorbeta in human breast tumors [J]. J Clin Endocrinol Metab, 1997; 82(7)∶2371.
13.	Leygue E, Dotzlaw H, Wastson PH, et al. Altered estrogen receptorα and β messenger RNA expression during human breast tumorigenesis [J]. Cancer Res, 1998; 58(15)∶3197.
14.	Speirs V, Parkes AT, Kerin MJ, et al. Coexpression of estrogen receptor α and β: poor prognostic factors in human breast cancer？ [J]. Cancer Res, 1999; 59(3)∶525.
15.	Dotzlaw H, Leygue E, Wastson PH,et al. Estrogen receptorβ messenger RNA expression in human breast tumor biopsies: relationship to steroid receptor status and regulation by progestins [J].Cancer Res, 1999; 59(3)∶529.
16.	Speirs V, Malone C, Walton DS, et al. Increased expression of estrogen receptor beta mRNA in tamoxifenresistant breast cancer patients [J]. Cancer Res, 1999; 59(21)∶5421.
17.	Fuqua SA, Fitzgerald SD, Allred DC,et al. Inhibition of estrogen receptor action by a naturally occuring variant in human breast tumors [J]. Cancer Res,1992; 52(2)∶483.
18.	Vladusic EA, Hornby AE, GuerraVladusic FK, et al. Expression of estrogen receptor beta messenger RNA variant in breast cancer [J]. Cancer Res, 1998; 58(2)∶210.
19.	Pfeffer U, Fecarotta E, Castagnetta L,et al. Estrogen receptor messenger RNA lacking exon 4 in estrogenresponsive human breast cancer cell lines [J]. Cancer Res, 1993; 53(4)∶741.
20.	Moore JT, McKee DD, SlentzKesler K,et al. Cloning and characterization of human estrogen receptor beta isoforms [J]. Biochem Biophys Res Commun,1998; 247(1)∶75.
21.	Leygue E, Dotzlaw H, Watson PH,et al. Expression of estrogen receptor beta1, beta2 and beta5 messenger RNAs in human breast tissue [J]. Cancer Res, 1999; 59(6)∶1175.
22.	Fuqua SA, Schiff R, Parra I,et al. Expression of wildtype estrogen receptor beta and variant isoforms in human breast cancer [J]. Cancer Res,1999; 59(21)∶5425.

1. Kuiper GG, Enmark E, PeltoHuikko M, et al. Cloning of a novel receptor expressed in rat prostate and ovary [J]. Proc Natl Acad Sci USA, 1996; 93(12)∶5925.
2. Mosselman S, Polman J, Dijkema R. ER beta: identification and characterization of a novel human estrogen receptor [J]. FEBS Lett,1996; 392(1)∶49.
3. Tremblay GB, Tremblay A, Copeland NG, et al. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta [J]. Mol Endocrinol, 1997; 11(3)∶353.
4. Enmark E, PeltoHuikko M, Grandien K, et al. Human estrogen receptor betagene structure, chromosomal localization， and expression pattern [J]. J Clin Endocrinol Metab,1997; 82(12)∶4258.
5. Gustafsson JA. Estrogen receptor betaa new dimension in estrogen mechanism of action [J]. J Endocrinol,1999; 163(3)∶379.
6. Kuiper GG, Carlsson B, Grandien K, et al. Comparision of the ligand binding specificity and transcript tissue distribution of estrogen receptor alpha and beta [J]. Endocrinology,1997; 138(3)∶863.
7. Cowley SM, Hoare S, Mosselman S, et al.Estrogen receptors alpha and beta form heterodimers on DNA [J]. J Biol Chem,1997; 272(32)∶19858.
8. Pace P, Taylor J, Suntharalingam S, et al. Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha [J].J Biol Chem,1997; 272(41)∶25832.
9. Gaub MP，Bellard M, Scheuer I，et al. Activation of the ovalbumin gene by the estrogen receptor involves the fosjun complex [J].Cell 1990; 63(6)∶1267.
10. Paech K, Webb P, Kuiper GG,et al. Differential ligand activation of estrogen receptors ERalpha and ER beta at AP1 sites [J]. Science, 1997; 277(5331)∶1508.
11. Hall JM, McDonnell DP. The estrogen receptor betaisoform (ER beta) of the human estrogen receptor modulates ER alpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens [J].Endocrinology, 1999; 140(12)∶5566.
12. Dotzlaw H, Leygue E, Watson PH, et al. Expression of estrogen receptorbeta in human breast tumors [J]. J Clin Endocrinol Metab, 1997; 82(7)∶2371.
13. Leygue E, Dotzlaw H, Wastson PH, et al. Altered estrogen receptorα and β messenger RNA expression during human breast tumorigenesis [J]. Cancer Res, 1998; 58(15)∶3197.
14. Speirs V, Parkes AT, Kerin MJ, et al. Coexpression of estrogen receptor α and β: poor prognostic factors in human breast cancer？ [J]. Cancer Res, 1999; 59(3)∶525.
15. Dotzlaw H, Leygue E, Wastson PH,et al. Estrogen receptorβ messenger RNA expression in human breast tumor biopsies: relationship to steroid receptor status and regulation by progestins [J].Cancer Res, 1999; 59(3)∶529.
16. Speirs V, Malone C, Walton DS, et al. Increased expression of estrogen receptor beta mRNA in tamoxifenresistant breast cancer patients [J]. Cancer Res, 1999; 59(21)∶5421.
17. Fuqua SA, Fitzgerald SD, Allred DC,et al. Inhibition of estrogen receptor action by a naturally occuring variant in human breast tumors [J]. Cancer Res,1992; 52(2)∶483.
18. Vladusic EA, Hornby AE, GuerraVladusic FK, et al. Expression of estrogen receptor beta messenger RNA variant in breast cancer [J]. Cancer Res, 1998; 58(2)∶210.
19. Pfeffer U, Fecarotta E, Castagnetta L,et al. Estrogen receptor messenger RNA lacking exon 4 in estrogenresponsive human breast cancer cell lines [J]. Cancer Res, 1993; 53(4)∶741.
20. Moore JT, McKee DD, SlentzKesler K,et al. Cloning and characterization of human estrogen receptor beta isoforms [J]. Biochem Biophys Res Commun,1998; 247(1)∶75.
21. Leygue E, Dotzlaw H, Watson PH,et al. Expression of estrogen receptor beta1, beta2 and beta5 messenger RNAs in human breast tissue [J]. Cancer Res, 1999; 59(6)∶1175.
22. Fuqua SA, Schiff R, Parra I,et al. Expression of wildtype estrogen receptor beta and variant isoforms in human breast cancer [J]. Cancer Res,1999; 59(21)∶5425.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Estrogen Receptor Beta and Advances in Breast Cancer Research

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