Relationship Between Level of Nitric Oxide in the Blood of Portal Vein and the Hyperdynamic Circulatory Syndrome in Partial Portal Vein Ligative Rats_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Jijian ¹ , GAO Genwu ¹ , LIU Changan ¹ , et al. ²

Department of General Surgery, the Second Clinical College, Chongqing University of Medical Science, Chongqing 400010;

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Keywords：

Partial portal vein ligation Nitric oxide Nitric oxide synthase Hyperdynamic circulatory syndrome

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ObjectiveTo understand the effect of nitric oxide (NO) on the formation of hyperdynamic circulatory syndrome (HCS) and the influence of level of NO on HCS. MethodsAfter establishment of stable HCS in partial portal vein ligated rats,the quantity of NO in blood of portal vein and the activity of nitric oxide synthase (NOS) in liver were determined by pre and post injection of inhabitor of NOS (NGmethylLarginine) and hemodynamics was supervised simultaneously.ResultsThe quantity of NO was paralleled with the activity of NOS and was elevated markedly by 24 hours after operation and reached the top by 48 hours after surgery. These sequential changes were coincided with the dilation of general vascularture. There was a close relation between this changes and the formation of HCS.The quantity of NO and the activity of NOS were decreased significantly to the level of the control group after injection of NGmethylLarginine (LNMMA). LNMMA inhabited the activity of NOS and blocked the production of NO. HCS ameliorated obviously. ConclusionNO plays an important role in initiating the dilation of general vascularture and plays a critical role in the formation of HCS. HCS will be ameliorated obviously or be blocked completely by eliminating the effect of NO and the portal pressure will decreased significantly or recover to normal range.

Citation： WANG Jijian,GAO Genwu,LIU Changan,et al.. Relationship Between Level of Nitric Oxide in the Blood of Portal Vein and the Hyperdynamic Circulatory Syndrome in Partial Portal Vein Ligative Rats. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(6): 402-404. doi: Copy

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1. 王继见，高根五. 门脉高压症发病机理的研究近况 [Ｊ]. 中国普外基础与临床杂志，2000； 7（4）∶275.
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4. 梅小君, 顾正中. 一氧化氮对脑血流的调节 [Ｊ]. 生理科学进展,1995; 26(1)∶35.
5. Gadano AC, Sogni P, Yang S, et al. Endothelial calciumcalmodulin dependent nitric oxide synthase in the in vitro vascular hyporeactivity of portal hypertensive rats [Ｊ]. J Hepatol,1997; 26(3)∶678.
6. 管洪庚，陈易人. 一氧化氮与门静脉高压症 [Ｊ]. 中国普外基础与临床杂志，1998； 5（3）∶185.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Level of Nitric Oxide in the Blood of Portal Vein and the Hyperdynamic Circulatory Syndrome in Partial Portal Vein Ligative Rats

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