THE ROLE OF NITRIC OXIDE IN THE PATHOGENESIS OF RENAL DYSFUNCTION DURING ACUTE BILIARY INFECTION IN RATS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Hepatobiliary Surgery, The Second Affiliated Hospital， Kunming Medical College, Kunming 650101;

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Nitric oxide Biliary infection Renal dysfunction

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Objective To investigate the effect of nitric oxide (NO) on the renal function in acute biliary infection.
Methods 35 Wistar rats were divided randomly into acute biliary infection group (AC), group of AC with Larginine(L), group of L-NAME(N), group of simple biliary obstruction(O) and a sham-operated group(SO), and serum NO、 BUN、 Cr and NOS were determined and pathologic changes of liver and kidney were observed. Results NO and NOS were significantly higher in L group than in any other groups (P＜0.05), BUN and Cr were significantly lower than in AC and N groups (P＜0.05), but showed no significance compared with O group (P＞0.05). The pathology of kidney in L group showed a less severe change than that in AC group; NO and NOS in N group were lower than those in other groups. BUN and Cr were higher than those in other groups (P＜0.05). Conclusion NO has a protection for renal function in acute biliary infected rats the mechanism being related to its dilative effect on renal vessels and increased renal blood perfusion.

Citation： LI Zhiyu,ZHANG Bingyan,WANG Binghuang,et al.. THE ROLE OF NITRIC OXIDE IN THE PATHOGENESIS OF RENAL DYSFUNCTION DURING ACUTE BILIARY INFECTION IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(2): 69-71. doi: Copy

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1. 朱锡光，韩本立.一氧化氮在大鼠急性胆道感染后肝损伤中的作用及其机理研究 [J].第三军医大学学报，1997； 19（4）∶732.
2. Knowles RG, Merrett M, Salter M, et al. Differential induction of brain, liver and lung nitric oxide synthase by endotoxin in the rat [J]. Biochem J, 1990; 270(3)∶833.
3. 韩本立，龚建平，罗丁.大鼠急性胆道感染动物模型的建立 [J].中华实验外科杂志，1992； 9（1）∶10.
4. Moncade S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology [J]. Pharmacol Rev, 1991; 43(2)∶109.
5. Inan M, Sayek I, Tel BC, et al. Role of endotoxin and nitric oxide in the pathogenesis of renal failure in obstructive jaundice [J]. Br J Surg, 1997; 84(7)∶943.
6. Haddad IY, Pataki G, Hu P, et al. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury [J]. J Clin Chest, 1994; 94(6)∶2407.
7. 王根生，刘耕陶.一氧化氮与肝细胞损伤 [J].中华医学杂志，1995；75（1）∶57.
8. Endlich K, Muller C, Barthelmebs M, et al. Role of shear stress in nitric oxidedependent modulation of renal angiotensin II vasoconstriction [J]. Br J Pharmacol, 1999; 127(8)∶1929.
9. Olszanecki R, Chlopicki S. Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia [J]. J Physiol Pharmacol, 1999; 50(3)∶443.
10. Fierro IM, NascimentoDaSilva V, Arruda MA, et al. Induction of NOS in rat blood PMN in vivo and in vitro： modulation by tyrosine kinase and involvement in bactericidal activity [J]. J Leukoc Biol, 1999; 65(4)∶508.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE ROLE OF NITRIC OXIDE IN THE PATHOGENESIS OF RENAL DYSFUNCTION DURING ACUTE BILIARY INFECTION IN RATS

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