THE EFFECT OF CELLS APOPTOSIS WITH VARICOSITY IN THE LOWER EXTREMITIES_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

QIAO Zhengrong , SHI De.

Vascular Surgery Research Institute, First Hospital of Chongqing Medical University, Chongqing 400016;

Corresponding author：

Keywords：

Varicosity Cell apoptosis Collagens

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Objective To explore the effect of apoptosis and venous remodeling in the varicosity.
Methods By using TUNEL, Van Gieson collagen staining, venous wall image and transmission electron microscope, 83 patients with varicosity and 10 controls were studied.
Results Apoptosis and apoptosis index of ECs and SMC in cystic dilatations were compared with those of non-cystic dilatations and controls with significant difference(P＜0.01). The collagen content in patients with cystic dilatations and non-cystic dilatations were higher than that of controls (P＜0.05, P＜0.01). The venous wall of cystic dilatations become more thinner(P＜0.01). The regression and correlation analysis showed that collagen contents and SMC apoptosis index had significant effect on venous wall (r=0.9777,P＜0.001 and r=-0.5432, P=0.003) respectively. Electron microscopy confirmed apoptosis of ECs and SMC in varicosity. Conclusion Increased collagen content, increased cell apoptosis and reduced cell component lead to venous remodeling, and it may be one of the mechanism of varicosity.

Citation： QIAO Zhengrong,SHI De.. THE EFFECT OF CELLS APOPTOSIS WITH VARICOSITY IN THE LOWER EXTREMITIES. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(2): 91-94. doi: Copy

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1. Takeri SA. Surgical treatment of postphletitic syndrome with vein valve transplant [J]. Am J Surg, 1982; 144(4)∶221.
2. Schanzer HA. Rational approach to surgery of chronic venous stasis syndrome [J]. Ann Surg, 1982; 24(3)∶25.
3. Zukowski AJ, Nicolaides AN, Szendro G, et al. Haemodynamic significance of incompetent calf pertorating veins [J]. Br J Surg, 1991; 78(5)∶625.
4. Haimovicic H. Role of AV shunting in varicose veins:therapeutic implications [J]. J Cardiovasc Surg, 1995; 36(2)∶109.
5. Rose SS, Ahmed A. Some thoughts on the aetiology of varicose veins [J]. J Cardiovasc Surg, 1986; 27(5)∶534.
6. Gavrieli Y, Sherman Y, BenSasson SA. Identification of programmed cell death in situ Via specific labeling of nuclear DNA fragmentation [J]. J Cell Biol, 1992; 119(5)∶493.
7. Wijsman JM, Jonker PR, Keijzer R, et al. A new method to detect apoptosis in paraffin section [J]. J Histochem Cytochem, 1993; 41(4)∶7.
8. Kerr JF, Wyllie AH, Currie AR. Apoptosis:a basic biological phenomenon with wideranging implications in tissue kinetics [J]. Br J Cancer, 1972; 26(6)∶289.
9. Schwartzman PA, Cidlonski JA. The biochemistry and molecular biology of programmed cell death [J]. Endocr Rev, 1993; 14(3)∶133.
10. Geng YJ, Libbg P. Evidence for apoptosis in advanced human atheroma colocalization with interleukin1 betaconverting enzyme [J]. Am J Pathol, 1995; 147(2)∶251.
11. Bennett MR, Eran GZ, Schwatz SM. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaqucs [J]. J Clin Invest, 1995; 95(4)∶2266.
12. Karsan A, Yee E, Harlan JM. Endothelial cell death induced by tumor necrosis factoralpha is inhibited by the bcl2 family member [J], Ai J Biol Chem, 1996; 271(44)∶27201.
13. Yang JJ, Kettritz R, Panel Falk RJ, et al. Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase [J]. Am J Pathol 1996; 149(5)∶1617.
14. Kockx MM, Cambier BA, Bortiex HE, et al. Roam cell replication and smooth muscle cell apoptosis in human saphenous vein grafts [J]. Histopathology, 1994; 25(4)∶365.
15. Ross SS, Ahmed A. Some thoughts on the aetiology of varicose veins [J]. J Cardiovasc Surg, 1985; 27(5)∶534.
16. Parto LC, Silveriva PR Carvalho JJ, et al. Connective tissue accumulation in the muscle layer in normal and varicose saphenous veins [J]. Angiology, 1995; 46(3)∶243.
17. Tam EM, Glassberg E, Olsen DR, et al. Extracellular matrix gene expression by human endothelial and smooth muscle cells [J]. Matrix, 1991; 1(6)∶380.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE EFFECT OF CELLS APOPTOSIS WITH VARICOSITY IN THE LOWER EXTREMITIES

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