Objective To investigate the growth of tumors and the natural life length of the rats after the adriamycinethylcellulose microspheres(ADM-EC mc) were injected in the rats bearing transplantable liver cancer through their hepatic arteries.
Methods ADM-EC mc were infused into the proper hepatic arteries of the Wistar rats (W256). All of the rats were divided randomly into five groups, group 1: control, group 2: normal saline, group 3: conventional ADM, group 4: placebo ethylcellulose microspheres, and group 5: ADM-EC mc.
Results As compared with other four groups, the ADM-EC mc (group 5) showed the best inhibition of the growth of tumors and the longest mean life length of the rats.
Conclusion Hepatic arterial infusion of ADM-EC mc can inhibit the growth of the tumor, aggravate the necrosis, and improve the effects of the chemotherapy of liver cancer.
Citation:
PENG Fangxing,YAN Lnan,LIN Qiyuan,et al.. HEPATIC ARTERIAL CHEMOEMBOLIZATION OF ADRIAMYCIN-ETHYLCELLULOSE MICROSPHERES IN THE TREATMENT OF LIVER CANCER IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 138-140. doi:
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- 1. Kato T, Young K. Arterial chemoembolization with mitomycin microcapsules in the treatment of primary or secondary carcinoma of the kidney, liver, bone and intrap elvic organs 〔J〕. Cancer, 1981; 48(3)∶674.
- 2. Najib N, Suleiman MS. The Kinetics of drug release from ethy cellulose solid dipersions 〔J〕. Drug Dev Ind Pharm, 1985; 11(12)∶2169.
- 3. 盛浩,魏树礼.阿霉素毫微球制剂的研究进展 〔J〕.国外医学合成药、生化药、制剂分册,1996; 17(1)∶34.
- 4. 王义,吴孟超,张晓华等.肝动脉注射顺铂乙基纤维素微囊后血液及重要器官全面的分布研究 〔J〕.中华外科杂志,1990; 28(11)∶686.
- 5. 杨继金,朱永法,左龙京等.大白鼠转移性肝癌模型的制作 〔J〕.中华放射学杂志,1993; 27(2)∶122.
- 6. Kan ZX, Krassnodar I, Anders L, et al. In vivo microscopy of hepatic tumors in animal model: a dynamic investigation of blood supply to hepatic metastasis 〔J〕. Radiology, 1993; 187(3)∶621.
- 7. 张志荣,王丹,廖方义等.肝动脉栓塞米托蒽醌乙基纤维素微球的研究 〔J〕.药学学报,1996; 31(8)∶626.