Objective To study the relationship between early gastric cancer and MiB-1 expression.
Methods Resected early gastric cancer from 99 cases were studied by immunohistochemical method. Results MiB-1 proliferation index (MiB-1 PI) was related to patient ’s age, tumor size, location and depth of invasion. MiB-1 PI was higher in differentiated adenocarcinomas than in undifferentiated adenocarcinomas(P＜0.01). Cancers with lymphatic vessel invasion or lymph node metastasis had higher MiB-1 PI (P＜0.05). The postoperative survival was related to MiB-1 proliferation grade (MiB-1 PG), being higher in MiB-1 PG 1,2 grade than that in MiB-1 PG 3,4 grade.
Conclusion Even in the early stage of gastric cancer, tumor proliferation activity was related to patients’ prognosis.
Citation：
CHE Xiangming,WANG Kang,SHUICHI Hokita et al.. MiB-1 EXPRESSION IN EARLY GASTRIC CANCER：ASSOCIATED WITH CLINICOPATHOLOGY AND PROGNOSIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 145-147. doi:
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| 1. |
Key G, Becher MHG, Duchrow M, et al. New Ki67 equivalent murine monoclonal antibodies (MiB1) prepared against recombinant parts of the Ki67 antigen 〔J〕. Anal Cell Pathol, 1992； 4(2)∶181.
|
| 2. |
Moul JW, Bettencourt MC, Sesterhern IA, et al. Protein expression of p53, bcl2 and Ki67 (MiB1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer 〔J〕. Surgery, 1996； 120(2)∶159.
|
| 3. |
Lam KY, Law SY, So MK, et al. Prognostic implication of proliferative markers MiB1 and PC10 in esophageal squamous cell carcinoma 〔J〕. Cancer, 1996； 77(1)∶7.
|
| 4. |
Japanese research society for gastric cancer. The general rules for the gastric study 〔C〕. 12th endition. Tokyo. Kanehara & CO, LTD.1993∶1-53.
|
| 5. |
Muller W, Schneiders A, Meier S, et al. Immunohistochemical study on the prognosis value of MiB 1 in gastric carcinoma 〔J〕. Br J Cancer, 1996； 74(5)∶759.
|
| 6. |
Frank RE, Saclarides TJ, Leurgans S, et al. Tumor angiogenesis as a predicator of recurrence and survival in patients with nodenegative colon cancer 〔J〕. Anal Surg, 1995； 222(6)∶695.
|
| 7. |
Kimura H, Yonemura Y, Epstein AL. Flowcytometric quantitation of the proliferation associated nuclear antigen p105 and DNA content in advanced gastric cancer 〔J〕. Cancer, 1991； 68(12)∶2175.
|
| 8. |
Saitoh K, Chiba T, Nakamura K. Cell proliferation kinetics of human gastric carcinoma:an immunohistochemical study with a monoclonal antibody against DNA polymeraseα 〔J〕. Euro J Cancer, 1992； 28（10）∶1642.
|
| 9. |
车向明，帆北修一，爱甲孝.70岁以上老年人早期胃癌的临床病理特点 〔J〕.中国普通外科杂志，1997； 6(3)∶129.
|
| 10. |
车向明，帆北修一，爱甲孝.早期胃癌的临床病理特点 〔J〕.西安医科大学学报,1997； 8(2)∶15.
|
| 11. |
Kidama Y, Inoduchi K, Spejima K, et al. Growth patterns and prognosis in early gastric carcinoma superficially spreading and penetrating growth types 〔J〕. Cancer , 1983； 52(2)∶320.
|
- 1. Key G, Becher MHG, Duchrow M, et al. New Ki67 equivalent murine monoclonal antibodies (MiB1) prepared against recombinant parts of the Ki67 antigen 〔J〕. Anal Cell Pathol, 1992； 4(2)∶181.
- 2. Moul JW, Bettencourt MC, Sesterhern IA, et al. Protein expression of p53, bcl2 and Ki67 (MiB1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer 〔J〕. Surgery, 1996； 120(2)∶159.
- 3. Lam KY, Law SY, So MK, et al. Prognostic implication of proliferative markers MiB1 and PC10 in esophageal squamous cell carcinoma 〔J〕. Cancer, 1996； 77(1)∶7.
- 4. Japanese research society for gastric cancer. The general rules for the gastric study 〔C〕. 12th endition. Tokyo. Kanehara & CO, LTD.1993∶1-53.
- 5. Muller W, Schneiders A, Meier S, et al. Immunohistochemical study on the prognosis value of MiB 1 in gastric carcinoma 〔J〕. Br J Cancer, 1996； 74(5)∶759.
- 6. Frank RE, Saclarides TJ, Leurgans S, et al. Tumor angiogenesis as a predicator of recurrence and survival in patients with nodenegative colon cancer 〔J〕. Anal Surg, 1995； 222(6)∶695.
- 7. Kimura H, Yonemura Y, Epstein AL. Flowcytometric quantitation of the proliferation associated nuclear antigen p105 and DNA content in advanced gastric cancer 〔J〕. Cancer, 1991； 68(12)∶2175.
- 8. Saitoh K, Chiba T, Nakamura K. Cell proliferation kinetics of human gastric carcinoma:an immunohistochemical study with a monoclonal antibody against DNA polymeraseα 〔J〕. Euro J Cancer, 1992； 28（10）∶1642.
- 9. 车向明，帆北修一，爱甲孝.70岁以上老年人早期胃癌的临床病理特点 〔J〕.中国普通外科杂志，1997； 6(3)∶129.
- 10. 车向明，帆北修一，爱甲孝.早期胃癌的临床病理特点 〔J〕.西安医科大学学报,1997； 8(2)∶15.
- 11. Kidama Y, Inoduchi K, Spejima K, et al. Growth patterns and prognosis in early gastric carcinoma superficially spreading and penetrating growth types 〔J〕. Cancer , 1983； 52(2)∶320.
