MiB-1 EXPRESSION IN EARLY GASTRIC CANCER：ASSOCIATED WITH CLINICOPATHOLOGY AND PROGNOSIS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061;

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Keywords：

MiB-1 Early gastric cancer Lymph node metastasis Proliferation index Prognosis

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Objective To study the relationship between early gastric cancer and MiB-1 expression.
Methods Resected early gastric cancer from 99 cases were studied by immunohistochemical method. Results MiB-1 proliferation index (MiB-1 PI) was related to patient ’s age, tumor size, location and depth of invasion. MiB-1 PI was higher in differentiated adenocarcinomas than in undifferentiated adenocarcinomas(P＜0.01). Cancers with lymphatic vessel invasion or lymph node metastasis had higher MiB-1 PI (P＜0.05). The postoperative survival was related to MiB-1 proliferation grade (MiB-1 PG), being higher in MiB-1 PG 1,2 grade than that in MiB-1 PG 3,4 grade.
Conclusion Even in the early stage of gastric cancer, tumor proliferation activity was related to patients’ prognosis.

Citation： CHE Xiangming,WANG Kang,SHUICHI Hokita et al.. MiB-1 EXPRESSION IN EARLY GASTRIC CANCER：ASSOCIATED WITH CLINICOPATHOLOGY AND PROGNOSIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 145-147. doi: Copy

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6.	Frank RE, Saclarides TJ, Leurgans S, et al. Tumor angiogenesis as a predicator of recurrence and survival in patients with nodenegative colon cancer 〔J〕. Anal Surg, 1995； 222(6)∶695.
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8.	Saitoh K, Chiba T, Nakamura K. Cell proliferation kinetics of human gastric carcinoma:an immunohistochemical study with a monoclonal antibody against DNA polymeraseα 〔J〕. Euro J Cancer, 1992； 28（10）∶1642.
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10.	车向明，帆北修一，爱甲孝.早期胃癌的临床病理特点〔J〕.西安医科大学学报,1997； 8(2)∶15.
11.	Kidama Y, Inoduchi K, Spejima K, et al. Growth patterns and prognosis in early gastric carcinoma superficially spreading and penetrating growth types 〔J〕. Cancer , 1983； 52(2)∶320.

1. Key G, Becher MHG, Duchrow M, et al. New Ki67 equivalent murine monoclonal antibodies (MiB1) prepared against recombinant parts of the Ki67 antigen 〔J〕. Anal Cell Pathol, 1992； 4(2)∶181.
2. Moul JW, Bettencourt MC, Sesterhern IA, et al. Protein expression of p53, bcl2 and Ki67 (MiB1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer 〔J〕. Surgery, 1996； 120(2)∶159.
3. Lam KY, Law SY, So MK, et al. Prognostic implication of proliferative markers MiB1 and PC10 in esophageal squamous cell carcinoma 〔J〕. Cancer, 1996； 77(1)∶7.
4. Japanese research society for gastric cancer. The general rules for the gastric study 〔C〕. 12th endition. Tokyo. Kanehara & CO, LTD.1993∶1-53.
5. Muller W, Schneiders A, Meier S, et al. Immunohistochemical study on the prognosis value of MiB 1 in gastric carcinoma 〔J〕. Br J Cancer, 1996； 74(5)∶759.
6. Frank RE, Saclarides TJ, Leurgans S, et al. Tumor angiogenesis as a predicator of recurrence and survival in patients with nodenegative colon cancer 〔J〕. Anal Surg, 1995； 222(6)∶695.
7. Kimura H, Yonemura Y, Epstein AL. Flowcytometric quantitation of the proliferation associated nuclear antigen p105 and DNA content in advanced gastric cancer 〔J〕. Cancer, 1991； 68(12)∶2175.
8. Saitoh K, Chiba T, Nakamura K. Cell proliferation kinetics of human gastric carcinoma:an immunohistochemical study with a monoclonal antibody against DNA polymeraseα 〔J〕. Euro J Cancer, 1992； 28（10）∶1642.
9. 车向明，帆北修一，爱甲孝.70岁以上老年人早期胃癌的临床病理特点〔J〕.中国普通外科杂志，1997； 6(3)∶129.
10. 车向明，帆北修一，爱甲孝.早期胃癌的临床病理特点〔J〕.西安医科大学学报,1997； 8(2)∶15.
11. Kidama Y, Inoduchi K, Spejima K, et al. Growth patterns and prognosis in early gastric carcinoma superficially spreading and penetrating growth types 〔J〕. Cancer , 1983； 52(2)∶320.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

MiB-1 EXPRESSION IN EARLY GASTRIC CANCER：ASSOCIATED WITH CLINICOPATHOLOGY AND PROGNOSIS

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