Objective To evaluate the effect of the allied chemotherapy with 5-Fu、leucovorin (CF) and levamisole (LV) after resection of colorectal cancer.
Methods 242 cases were divided randomly into three groups. 80 cases (group Ⅰ) were treated with 5-Fu and CF. 80 cases(groupⅡ) were treated with 5-Fu and LV. 82 cases (group Ⅲ) were treated with 5-Fu、CF and LV. Results The recurrence rates of group Ⅲ was 12.20%, which was significantly lower than that of group Ⅰ (26.25%) and group Ⅱ(27.50%). (P＜0.05). The 5-year survival rates in group Ⅰ, group Ⅱ and group Ⅲ were 37.50%, 35.00% and 58.54%, respectively, the highest one was in Group Ⅲ (P＜0.01).
Conclusion The allied chemotherapy with 5-Fu、CF and LV is an effective therapy for petients of colorectal cancer after surgery, which can significantly decrease the recurrence and improve the 5-year survival rate.
Citation：
ZHUANG Chaoping,SHEN Wenl,WU Junwei,et al.. CLINICAL STUDY ON THE ALLIED CHEMOTHERAPY WITH 5-Fu、LEUCOVORIN AND LEVAMISOLE AFTER COLORECTAL CANCER SURGERY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 164-165. doi:
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- 1. Grem JL, Hoth DF, Hamilton JM, et al. Overview of current status and future direction of clinical trials with 5fluorouracil in comlination with folinic alid 〔J〕. Cancer Treat Rep, 1987； 71(8)∶1249.
- 2. Ehrlichman C, Fine S, Wong A, et al. A comparison of 5fluorouracil and folinic acid versus 5Fu in metastatic colorectal cancer 〔J〕. Proc Am Soc Clin, 1986； 5(2)∶82.
- 3. 管忠震，何友兼，刘茂珍等.大剂量荃醛氢叶酸合并氟脲嘧啶〔HDCF/5Fu〕治疗晚期胃肠道癌的探讨 〔J〕.癌症，1989; 8(6)∶421.
- 4. Guyatt G, Mitchell A. Advanced Colorectal Cancer MeraAnalysis Project. Modutation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate 〔J〕. J Clin Onw, 1992； 10(6)∶625.
- 5. 郑秀立，潘良熹，黄富麟等.高低剂量醛氢叶酸合并氟脲嘧啶治疗晚期胃肠道癌 〔J〕.肿瘤防治研究，1994； 21(5)∶323.
- 6. Moertel CG. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma 〔J〕. New Engl J Med, 1990； 322(4)∶352.
- 7. Grem JL. Current treatment approaches in colorectal cancer 〔J〕. Sem Oncaal, 1991； 18(Suppl 1)∶17.
- 8. 吴阶平，裘法祖主编.黄家驷外科学 〔M〕.第5版. 北京：人民卫生出版社，1992∶1288～1289.
