EXPRESSION OF mRNA OF CD15 AND nm23H1 IN HEPATOCELLULAR CARCINOMA AND THEIR SIGNIFICANCE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Pathology, The 251th Hospital of PLA, Zhangjiakou 075000;

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Keywords：

Hepatocellular carcinoma CD15 mRNA nm23H1 mRNA Immunohistochemistry In situ hybridization

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Objective To investigate the association of the expression of CD15 mRNA with the invasion and prognosis of hepatocellular carcinoma (HCC) and the expression of nm23H1 mRNA.
Methods In situ hybridization and immunohistochemistry methods were used to detect the expression of CD15 mRNA and protein nm23H1 mRNA in HCC.
Results In 99 cases of HCC, the positive rate of CD15 mRNA,its protein and nm23H1 mRNA were 38.4%, 36.4% and 76.8%, respectively. The expression of CD15 mRNA was consistent with its protein and negatively correlated with the expression of nm23H1 mRNA. The expression of CD15 mRNA and its protein, nm23H1 mRNA were associated with the invasiveness and metastasis of HCC and the prognosis of HCC patients.
Conclusion The detection of CD15 expression could be a new pathological biology index to judge the metastasis and prognosis of HCC.

Citation： GU uaping,NI Canrong,ZHAN Rongzhou,et al.. EXPRESSION OF mRNA OF CD15 AND nm23H1 IN HEPATOCELLULAR CARCINOMA AND THEIR SIGNIFICANCE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(4): 242-244. doi: Copy

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8.	倪灿荣, 范森, 许炳基. CSA系统在免疫组织化学中的应用〔Ｊ〕. 临床与实验病理学杂志, 1999; 15(3)∶267.
9.	倪灿荣, 朱明华, 马大烈. 催化信号放大系统在原位杂交检测中的应用研究〔Ｊ〕. 中国组织化学与细胞化学杂志, 2000; 9(1)∶110.
10.	Backer JM, Mendola CE, Kovesdi I, et al. Chromosomal localization and mucleoside diphosphate kinase activity of human metastasisuppressor genes nm23H1 and nm23H2 〔Ｊ〕. Oncogene, 1993; 8(4)∶497.

1. Yamaguchi A, Ding K, Machara M, et al. Expression of nm23H1 gene and slalyl Lewis X antigen in breast cancer 〔Ｊ〕. Oncology, 1998; 55(4)∶357.
2. Yamaguchi A, Goi A, Seki K, et al. Clinical significancer of combined immunohistochemical detection of CD44v and sialyl LeX expression for colrecatal cancer patients undergoing curative resection 〔Ｊ〕. Oncology, 1998; 55(5)∶400.
3. 谷化平, 尚培中, 纪小龙等. 甲状腺肿瘤CD15抗原表达及临床意义〔Ｊ〕.中华内分泌代谢杂志, 2000; 16(1)∶31.
4. 谷化平, 周翠玲, 尚培中. 胆囊癌组织CD15和cerbB2表达及相关性研究〔Ｊ〕. 肝胆胰外科杂志, 2000; 12(1)∶20.
5. 谷化平, 尚培中, 苏红等. CD15、p53和CathD在子宫内膜腺癌的表达及临床意义〔Ｊ〕. 中国医师杂志, 1999; 1(2)∶13.
6. Torii A, Nakayama A, Harada A, et al. Expression of the CD15 antigen in hepatocellular carcinoma 〔Ｊ〕. Cancer, 1993; 71(12)∶3864.
7. Bolos CD, Garrido M, Real FX. Mucb apomucin shows a distinct normal tissue distribution that corkelater with lewis antigen expression in the human stomach 〔Ｊ〕. Gastroenterology, 1995; 109(3)∶723.
8. 倪灿荣, 范森, 许炳基. CSA系统在免疫组织化学中的应用〔Ｊ〕. 临床与实验病理学杂志, 1999; 15(3)∶267.
9. 倪灿荣, 朱明华, 马大烈. 催化信号放大系统在原位杂交检测中的应用研究〔Ｊ〕. 中国组织化学与细胞化学杂志, 2000; 9(1)∶110.
10. Backer JM, Mendola CE, Kovesdi I, et al. Chromosomal localization and mucleoside diphosphate kinase activity of human metastasisuppressor genes nm23H1 and nm23H2 〔Ｊ〕. Oncogene, 1993; 8(4)∶497.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EXPRESSION OF mRNA OF CD15 AND nm23H1 IN HEPATOCELLULAR CARCINOMA AND THEIR SIGNIFICANCE

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