Objective To research the changes in plasma endothelin, LPS, TNF-α, IL-6 and IL-8 in the patients with obstructive jaundice (OJ) and non-obstructive jaundice (NOJ) after surgery.
Methods The plasma ET, LPS, TNF-α, IL-6 and IL-8 were measured in 15 patients without jaundice as controls.
Results As compared with NOJ, the postoperative changes of ET, LPS, TNF-α, IL-6 and IL-8 in OJ group increased significantly at multiple time points (P＜0.05).
Conclusion There is interaction between ET,LPS, TNF-α, IL-6 and IL-8 and damage to multiple organ function in patients with OJ after surgery.
Citation：
PENG Bing,WU Yantao,WANG Xiangdong,et al.. STUDY ON THE CHANGE OF PLASMA ENDOTHELIN,LPS,TNF-α,IL-6 AND IL-8 IN PATIENTS WITH OBSTRUCTIVE JAUNDICE AFTER SURGERY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(4): 245-246. doi:
Copy
Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
王齐欣, 陆玮, 林善琰. 内皮素与肝肾综合症 〔Ｊ〕. 国外医学消化系统疾病分册, 1998; 18(2)∶103.
|
| 2. |
Grave J, Gouma D, Buuramn W. Complications in obstructive jaundice: role of endotoxins 〔Ｊ〕. Scand J Gastroenterol, 1992; 194(Suppl)∶8.
|
| 3. |
ScottConner CE, Grogan JB. The path physiology of biliary obstruction and its effect on phagocytic and immune function 〔Ｊ〕. J Surg Res, 1994; 57(2)∶316.
|
| 4. |
Sheron N, Lan JYN, Hofman J, et al. Dose dependent increase in plasma interleukin6 after recombinant tumor necrosis factor infusion in humans 〔Ｊ〕. Clin Exp Immunol, 1990; 82（3）∶427.
|
| 5. |
O’Nail S, Hunt J, Filkins J, et al. Obstruction jaundice in rats results in exaggerated hepatic production of TNFα and systemic and tissue TNFα and systemic and tissue TNFα levels after endotoxin 〔Ｊ〕. Surgery, 1997; 122(2)∶281.
|
| 6. |
Jones A, Selbx P, Viner C, et al. Tumor necrosis factor cholestatic jaundice and chronic liver disease 〔Ｊ〕. Gut, 1992; 31（8）∶938.
|
| 7. |
蔺小红, 席宏丽, 斯崇文. 肝硬化并发自发性细菌性腹膜炎患者腹水中TNFα及IL6的测定及其意义 〔Ｊ〕. 北京医科大学学报, 1999; 31(3)∶285.
|
- 1. 王齐欣, 陆玮, 林善琰. 内皮素与肝肾综合症 〔Ｊ〕. 国外医学消化系统疾病分册, 1998; 18(2)∶103.
- 2. Grave J, Gouma D, Buuramn W. Complications in obstructive jaundice: role of endotoxins 〔Ｊ〕. Scand J Gastroenterol, 1992; 194(Suppl)∶8.
- 3. ScottConner CE, Grogan JB. The path physiology of biliary obstruction and its effect on phagocytic and immune function 〔Ｊ〕. J Surg Res, 1994; 57(2)∶316.
- 4. Sheron N, Lan JYN, Hofman J, et al. Dose dependent increase in plasma interleukin6 after recombinant tumor necrosis factor infusion in humans 〔Ｊ〕. Clin Exp Immunol, 1990; 82（3）∶427.
- 5. O’Nail S, Hunt J, Filkins J, et al. Obstruction jaundice in rats results in exaggerated hepatic production of TNFα and systemic and tissue TNFα and systemic and tissue TNFα levels after endotoxin 〔Ｊ〕. Surgery, 1997; 122(2)∶281.
- 6. Jones A, Selbx P, Viner C, et al. Tumor necrosis factor cholestatic jaundice and chronic liver disease 〔Ｊ〕. Gut, 1992; 31（8）∶938.
- 7. 蔺小红, 席宏丽, 斯崇文. 肝硬化并发自发性细菌性腹膜炎患者腹水中TNFα及IL6的测定及其意义 〔Ｊ〕. 北京医科大学学报, 1999; 31(3)∶285.
