THE SIGNIFICANCE OF CYCLIN D1 AND P53 PROTEIN EXPRESSION IN BREAST CARCINOMA AND FIBROSARCOMA INDUCED BY DMBA IN RATS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Yi ¹ , JIANG Jun ¹ , HAN Xiaorong ¹ , et al. ²

Department of General Surgery, South West Hospital,Third Military Medical University, Chongqing 400038;

Corresponding author：

Keywords：

p53 protein cyclin D1 Breast carcinoma Fibrosarcoma

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【Abstract】Objective To investigate the significance of cyclin D1 and p53 protein expression in synchronous breast carcinoma and fibrosarcoma in rats. Methods Immunohistochemical SP methods was used to study the expression of cyclin D1 and p53 in synchronous breast carcinoma and fibrosarcoma induced by DMBA in rats.Results There was no expression of cyclin D1 and p53 in normal breast tissue. In atypical hyperplasia of mammary, there was overexpression of cyclin D1(7/14) and no expression of p53. The overexpression of cyclin D1 and p53 were detected in breast carcinoma (8/18,7/18 respectively) and fibrosarcoma (9/14,5/14 respectively). There was no expression of cyclin D1 and p53 in adjacent sarcoma.The expression of cyclin D1 and p53 protein was associated with histological grading, and showed inverse relation between them. Conclusion There are cyclin D1 and p53 protein overexpression in the synchronous breast carcinoma and fibrosarcoma induced by DMBA in rats. Cyclin D1 may paticipate in the course of the carcinogenesis of breast carcinoma and fibrosarcoma in rats, and p53 protein overexpression may relate to the degree of malignancy of the tumors.

Citation： ZHANG Yi,JIANG Jun,HAN Xiaorong,et al.. THE SIGNIFICANCE OF CYCLIN D1 AND P53 PROTEIN EXPRESSION IN BREAST CARCINOMA AND FIBROSARCOMA INDUCED BY DMBA IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 285-287. doi: Copy

1.	华长江,殷广福,许正昌.胃肠道多原发癌的及时诊断和治疗〔Ｊ〕.实用癌症杂志,1994; 9(2)∶115.
2.	姜军,詹新恩,陈意生等.多原发性恶性肿瘤模型的建立〔Ｊ〕. 第三军医大学学报,1996; 18(4)∶323.
3.	高进主编.肿瘤学基础与实验〔M〕. 第1版. 北京: 人民卫生出版社,1999∶410~411.
4.	Russell WO, Cohen J, Enzinger F, et al. A clinical and pathological staging system for soft tissue sarcomas 〔Ｊ〕. Cancer, 1977; 40(7)∶1562.
5.	Bito T,Ueda M,Ahmed NU,et al.Cyclin D and retinoblastoma gene product expression in actinic deratosis and cutanious squamous cell carcinoma in relation to p53 expression 〔Ｊ〕. J Cutan Pathol,1998; 22(3)∶427.
6.	Lee CC,Yananoto S,Morimura K,et al. Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features 〔Ｊ〕. Cancer, 1997; 79(4)∶789.
7.	Zhang SY,Caamano J,Cooper F,et al.Immunohistochemistry of cyclin D1 in human breast cancer 〔Ｊ〕. Am J Clin Pathol,1994; 102(5)∶695.
8.	Naitoh H,Shibata J,Kawaguchi A,et al.Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer 〔Ｊ〕. Am J Pathol, 1999; 146(1)∶161.
9.	Nishida N,Fukuda Y,Komeda T,et al.Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma 〔Ｊ〕. Cancer Res,1994; 54(14)∶3107.
10.	Betticher DC, Heighway J, Hasleton PS,et al. Prognostic significance of CCND1(cyclin D1) overexpression in primary resected nonsmallcell lung cancer 〔Ｊ〕. Br J Cancer, 1996; 73(4)∶294.
11.	Giannino DS,Murphy M,Ruaro EM,et al. Cyclin D1 and p21/war1 are both involved in p53 growth suppression 〔Ｊ〕 . Oncogene 1998; 12(2)∶177.
12.	Mansukhani MM,Osborne BM,Zhong JZ,et al.The pattern of p53 and p21waf1/cip1 immunoreactivity in nonHodgkins lymphomas predicts p53 gene status 〔Ｊ〕. Diag Mol Patho, 1997; 6(4)∶222.
13.	Worsley SD, Jenmngs BA, Khalil, KH, et al. Cyclin D1 amplification and expression in human breast carcinoma: correlation with histological prognostic markers and oestrogen receptor expression 〔Ｊ〕. J Clin Pathol, 1996; 49(1)∶46.

1. 华长江,殷广福,许正昌.胃肠道多原发癌的及时诊断和治疗〔Ｊ〕.实用癌症杂志,1994; 9(2)∶115.
2. 姜军,詹新恩,陈意生等.多原发性恶性肿瘤模型的建立〔Ｊ〕. 第三军医大学学报,1996; 18(4)∶323.
3. 高进主编.肿瘤学基础与实验〔M〕. 第1版. 北京: 人民卫生出版社,1999∶410~411.
4. Russell WO, Cohen J, Enzinger F, et al. A clinical and pathological staging system for soft tissue sarcomas 〔Ｊ〕. Cancer, 1977; 40(7)∶1562.
5. Bito T,Ueda M,Ahmed NU,et al.Cyclin D and retinoblastoma gene product expression in actinic deratosis and cutanious squamous cell carcinoma in relation to p53 expression 〔Ｊ〕. J Cutan Pathol,1998; 22(3)∶427.
6. Lee CC,Yananoto S,Morimura K,et al. Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features 〔Ｊ〕. Cancer, 1997; 79(4)∶789.
7. Zhang SY,Caamano J,Cooper F,et al.Immunohistochemistry of cyclin D1 in human breast cancer 〔Ｊ〕. Am J Clin Pathol,1994; 102(5)∶695.
8. Naitoh H,Shibata J,Kawaguchi A,et al.Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer 〔Ｊ〕. Am J Pathol, 1999; 146(1)∶161.
9. Nishida N,Fukuda Y,Komeda T,et al.Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma 〔Ｊ〕. Cancer Res,1994; 54(14)∶3107.
10. Betticher DC, Heighway J, Hasleton PS,et al. Prognostic significance of CCND1(cyclin D1) overexpression in primary resected nonsmallcell lung cancer 〔Ｊ〕. Br J Cancer, 1996; 73(4)∶294.
11. Giannino DS,Murphy M,Ruaro EM,et al. Cyclin D1 and p21/war1 are both involved in p53 growth suppression 〔Ｊ〕 . Oncogene 1998; 12(2)∶177.
12. Mansukhani MM,Osborne BM,Zhong JZ,et al.The pattern of p53 and p21waf1/cip1 immunoreactivity in nonHodgkins lymphomas predicts p53 gene status 〔Ｊ〕. Diag Mol Patho, 1997; 6(4)∶222.
13. Worsley SD, Jenmngs BA, Khalil, KH, et al. Cyclin D1 amplification and expression in human breast carcinoma: correlation with histological prognostic markers and oestrogen receptor expression 〔Ｊ〕. J Clin Pathol, 1996; 49(1)∶46.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE SIGNIFICANCE OF CYCLIN D1 AND P53 PROTEIN EXPRESSION IN BREAST CARCINOMA AND FIBROSARCOMA INDUCED BY DMBA IN RATS

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