RELATIONSHIP BETWEEN ANGIOGENESIS AND p53, c-erb B-2 ONCOGENE PROTEIN IN MALIGNANT AND PRECANCEROUS LESIONS IN BREAST_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Shengchun , WU Kainan , LI Hongyuan , et al.

Department of General Surgery, First Affiliated Hospital， Chongqing University of Medical Sciences, Chongqing 400016;

Corresponding author：

Keywords：

Angiogenesis p53 oncogene protein c-erb B-2 oncogene protein Breast atypical hyperplasia Breast carcinoma

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【Abstract】Objective To investigate the association between p53, c-erb B-2 oncogene protein and angiogenesis in breast carcinoma and breast with atypical hyperplasia. Methods Immunohistochemical reaction of p53, c-erb B-2 oncogene protein was evaluated in 103 benign and malignant lesion breast paraffin-embedded specimens. The microvessel endothelial area (MEA) was quantitated by computer image analysis system (CIAS), which was immunohistochemically stained by FⅧ-RA. The relationships between p53, c-erb B-2 and MEA were analyzed.
Results The MEA of p53 oncogene protein positive expression in mild atypical hyperplasia breast lesion was significantly higher than that in p53 negative (t=2.302 4,P＜0.05). The MEA of p53 oncogene protein positive expression in severe atypical hyperplasia was higher than that in p53 negative (t=2.179 4,P＜0.05). Moreover, no significant association between c-erb B-2 oncogene protein and MEA was observed. Conclusion p53 oncogene mutant,protein expression is significantly related to angiogenesis.

Citation： LIU Shengchun,WU Kainan,LI Hongyuan,et al.. RELATIONSHIP BETWEEN ANGIOGENESIS AND p53, c-erb B-2 ONCOGENE PROTEIN IN MALIGNANT AND PRECANCEROUS LESIONS IN BREAST. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 304-306. doi: Copy

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1. Page L. Cancer risk assessment in benign breast biopsies 〔Ｊ〕. Human Pathology, 1986; 17(8)∶ 817.
2. Vermeulen PB, Eynden G, Huget P, et al. Prospective study of intratumoral microvessel density, p53 expression and survival in colorectal cancer 〔Ｊ〕. Br J Cancer, 1999; 79(2)∶316.
3. Fontanini G, Boldrini L, Calcinai A, et al. Thrombospondins I and II messenger RNA expression in lung carcinoma: Relationship with p53 alterations, angiogenic growth factors,and vascular density 〔Ｊ〕. Clinical Cancer Research, 1999; 5(1)∶155.
4. Kang S, Maeda K, Onoda N, et al. Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis 〔Ｊ〕. Int J Cancer, 1997; 74(5)∶502.
5. Gasparini G, Weidner N, Maluta S, et al. Intratumoral microvessel density and p53 protein: correlation with metastasis in head and neck squamouscell carcinoma 〔Ｊ〕. Int J Cancer, 1993； 55(5)∶739.
6. Giatromanolaki A, Koukourakis M, Kakolyris S, et al. Vascular endothelial growth factor, wildtype p53, and angiogenesis in early operable nonsmall cell lung cancer 〔Ｊ〕 . Clinical Cancer Research, 1998; 4(12)∶3017.
7. Toi M, Kashitani T, Tominaga T. Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma 〔Ｊ〕. Int J Cancer, 1993; 55(3)∶371.
8. Charpin C, Devictor B, Bergeret D, et al. CD31 quantitative immunocytochemical assays in breast carcinomas, correlation with current prognostic factors 〔Ｊ〕. Am J Clin Pathol, 1995; 103(4)∶443.
9. Dameron K, Volpert O, Tainsky M, et al. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin1 〔Ｊ〕. Science, 1994; 265(9)∶1582.
10. Tai D, Fan R, Roy B. Controlling the vasculature: angiogenesis, antiangiogenesis and vascular targeting of gene therapy 〔Ｊ〕. Trends Pharmacol Sci, 1995; 16(2)∶57.
11. Mukhopadhyay D, Tsilkas L, Sukhatme P. Wildtype p53 and Vsrc exera opposing influences on human vascular endothelial growth factor gene expression 〔Ｊ〕. Cancer Research, 1995; 55 (24)∶6161.
12. Borg A, Tandon K, Sigurdsson H, et al. Her2/neu applification predicts poor survival in nodepositive breast cancer 〔Ｊ〕. Cancer Research, 1990; 50(14)∶4332.
13. Horak E, Leek R, Klenk N, et al. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer 〔Ｊ〕. Lancet, 1992; 340(7)∶1120.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

RELATIONSHIP BETWEEN ANGIOGENESIS AND p53, c-erb B-2 ONCOGENE PROTEIN IN MALIGNANT AND PRECANCEROUS LESIONS IN BREAST

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