【Abstract】Objective To study the relationship of the expression of CD44v6 mRNA and nm23H1 mRNA with the clinical pathology parameter and prognosis of breast cancer, and to investigate the correlation of the expression of CD44v6 mRNA and nm23H1 mRNA. Methods In situ hybridization and CSA immunohistochemistry method were used to detect the expression of CD44v6 mRNA and nm23H1 mRNA in 94 cases of breast cancer. Results The positive expression of CD44v6 mRNA and the negative expression of nm23H1 mRNA were positively correlated with the grading, clinical stage, lymph node metastasis, and recurrence and prognosis of breast cancer. CD44v6 mRNA expression and nm23H1 mRNA were negatively correlated in breast cancer. Patients who had positive expression of CD44v6 mRNA and negative expression of nm23H1 mRNA had a higher lymph node metastatic rate and a lower survival rate. Conclusion Several genes were involved in the occurrence and development of breast cancer in which the expression of CD44v6 mRNA has synergistic action in negative regulation with that of nm23H1 mRNA. Combined detection of the expression of these two mRNA is helpful to judge the metastasis, recurrence and prognosis of breast cancer.
Citation：
GU Huaping,NI Canrong,SHANG Peizhong,et al.. EXPRESSION OF mRNA OF CD44v6 AND nm23H1 IN BREAST CANCER AND THEIR SIGNIFICANCE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 307-309. doi:
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| 1. |
李树玲. 中国常见恶性肿瘤诊治规范 〔M〕. 北京: 北京医科大学、中国协和医科大学联合出版社,1990∶59~60.
|
| 2. |
倪灿荣, 朱明华, 马大烈. 催化信号放大系统在原位杂交检测中的应用研究 〔Ｊ〕. 中国组织化学与细胞化学杂志, 2000; 9(1)∶110.
|
| 3. |
Emak G, Jemings T, Robinson L, et al. Restricted pattern of CD44 variant exon expression in human papillary thyroid carcinoma 〔Ｊ〕. Cancer Res, 1996; 56(5)∶1037.
|
| 4. |
Kainz C, Tempfer C, Kohlberger P, et al. Immunohistochemical detection of adhesion molecule CD44 splice variants in lymphnode metastasis of cervial cancer 〔Ｊ〕. Int J Cancer, 1997; 74（2）∶185.
|
| 5. |
Christopher J, Amil K. CD44 isoform expression in primary and metastatic pancreatic adenocarcinoma 〔Ｊ〕. Cancer Res, 1995; 55（4）∶1831.
|
| 6. |
Hennessy C, Henry JA, May FE, et al. Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis 〔Ｊ〕. J Natl Cancer Inst, 1991; 83(4)∶281.
|
| 7. |
Sreeg PS, Rosa AD, Flatow U, et al. nm23 and breast cancer metastasis 〔Ｊ〕. Breast Cancer Research and Treatment, 1993; 2(2)∶175.
|
| 8. |
Arai T, Yamshita T, Urano T, et al. Preferential reduction of nm23H1 gene product in metastatic tissue from papillary and follicuar carcinoma of thyroid 〔Ｊ〕. Mad Pathal, 1995; 8(3)∶252.
|
- 1. 李树玲. 中国常见恶性肿瘤诊治规范 〔M〕. 北京: 北京医科大学、中国协和医科大学联合出版社,1990∶59~60.
- 2. 倪灿荣, 朱明华, 马大烈. 催化信号放大系统在原位杂交检测中的应用研究 〔Ｊ〕. 中国组织化学与细胞化学杂志, 2000; 9(1)∶110.
- 3. Emak G, Jemings T, Robinson L, et al. Restricted pattern of CD44 variant exon expression in human papillary thyroid carcinoma 〔Ｊ〕. Cancer Res, 1996; 56(5)∶1037.
- 4. Kainz C, Tempfer C, Kohlberger P, et al. Immunohistochemical detection of adhesion molecule CD44 splice variants in lymphnode metastasis of cervial cancer 〔Ｊ〕. Int J Cancer, 1997; 74（2）∶185.
- 5. Christopher J, Amil K. CD44 isoform expression in primary and metastatic pancreatic adenocarcinoma 〔Ｊ〕. Cancer Res, 1995; 55（4）∶1831.
- 6. Hennessy C, Henry JA, May FE, et al. Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis 〔Ｊ〕. J Natl Cancer Inst, 1991; 83(4)∶281.
- 7. Sreeg PS, Rosa AD, Flatow U, et al. nm23 and breast cancer metastasis 〔Ｊ〕. Breast Cancer Research and Treatment, 1993; 2(2)∶175.
- 8. Arai T, Yamshita T, Urano T, et al. Preferential reduction of nm23H1 gene product in metastatic tissue from papillary and follicuar carcinoma of thyroid 〔Ｊ〕. Mad Pathal, 1995; 8(3)∶252.
